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公开(公告)号：EP2336355A4
公开(公告)日：2012-06-06
申请号：EP09820656
申请日：2009-10-13
Applicant: SONY CORP
Inventor： SOMA HARUHIKO , YAMAMOTO TAKURO , AKASHI MAKOTO , NODE KOICHI , KISHII NORIYUKI , NAKAGAWA KAZUHIRO , YAMASHITA SHIKO , HAYAKAWA TOMOHIRO
CPC classification number: C12Q1/6876 , A61B10/02 , C12Q1/6809 , C12Q2600/158 , G06F19/20 , G06F19/24 , C12Q2537/165
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公开(公告)号：EP1864997A4
公开(公告)日：2009-02-25
申请号：EP06730113
申请日：2006-03-27
Applicant: SONY CORP
Inventor： YAMAMOTO TAKURO , MAMINE TAKAYOSHI , TAKUMI TORU , AKASHI MAKOTO
IPC: C07K14/47 , A61K31/7088 , A61K31/7105 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/00 , A61P25/20 , A61P35/00 , C12M1/00 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC classification number: A61K31/7105 , A61K31/7088 , C07K14/4702 , C07K14/70567 , G01N33/743 , G01N2333/70567 , G01N2500/00
Abstract: It is intended to clarify the undisclosed part of the mechanism controlling the circadian rhythm. It is newly found out that RORa (retinoic acid binding-receptor alpha, the same applies hereinafter) promotes the induction of Bmal1 expression and that the induction of Bmal1 expression is promoted under hypoxic conditions. These facts strongly suggest the presence of the mechanism controlling the circadian rhythm wherein, when RORa expression is promoted under hypoxic conditions etc., the induction of Bmal1 expression is promoted and the promotion of the induction of Bmal1 expression promotes the binding of BMAL1 to CLOCK to thereby promote the induction of the expression of the Per gene or the Cry gene. Accordingly, the above findings are likely applicable to agents for regulating jet lag and anticancer drugs.
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Patent Agency Ranking
公开(公告)号：EP2175035A4
公开(公告)日：2010-11-17
申请号：EP08791203
申请日：2008-07-16
Applicant: SONY CORP
Inventor： YAMAMOTO TAKURO , AKASHI MAKOTO , YAMASHITA SHIKO , ABE TOMOTERU , NAKAGAWA KAZUHIRO , SOMA HARUHIKO , NODE KOICHI , KISHII NORIYUKI , HAYAKAWA TOMOHIRO
CPC classification number: C12Q1/6881 , C12Q1/6876 , C12Q2600/158
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公开(公告)号：JP2009039086A
公开(公告)日：2009-02-26
申请号：JP2007210702
申请日：2007-08-13
Inventor： NAKAGAWA KAZUHIRO , ABE TOMOTERU , YAMAMOTO TAKUO , SOMA ATSUHIKO , YAMASHITA YUKIISA , AKASHI MAKOTO
IPC: C12Q1/68
Abstract: PROBLEM TO BE SOLVED: To provide a method for determining a gene expression amount using a proper control gene in a method for determining a gene expression in a hair follicle cell.
SOLUTION: The method for determining a gene expression is a method for determining the expression amount of an objective gene in a hair follicle cell, which comprises using one or more genes selected from a fixed gene described in a sequence listing and its homolog as a control gene. The method for determining a gene expression amount is favorably used especially when a gene having an expression amount of circadian change is an objective gene.
COPYRIGHT: (C)2009,JPO&INPITAbstract translation: 待解决的问题：提供在确定毛囊细胞中的基因表达的方法中使用适当的对照基因确定基因表达量的方法。 解决方案：用于确定基因表达的方法是确定毛囊细胞中目标基因的表达量的方法，其包括使用选自序列表中所述的固定基因的一种或多种基因及其同源物 作为对照基因。 特别是当具有昼夜变化表达量的基因是客观基因时，特别优选用于确定基因表达量的方法。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2010094072A
公开(公告)日：2010-04-30
申请号：JP2008267464
申请日：2008-10-16
Inventor： SOMA ATSUHIKO , YAMAMOTO TAKUO , AKASHI MAKOTO , NOIDE KOICHI , KISHII NORIYUKI , NAKAGAWA KAZUHIRO , YAMASHITA YUKIISA , HAYAKAWA TOMOHIRO
CPC classification number: C12Q1/6876 , A61B10/02 , C12Q1/6809 , C12Q2600/158 , G06F19/20 , G06F19/24 , C12Q2537/165
Abstract: PROBLEM TO BE SOLVED: To provide a method that minimizes number of times of collection of a biological sample from an individual to be tested and predicts biorhythm with high precision.
SOLUTION: The method for predicting biorhythm of an individual to be tested includes measuring amounts of expression of two clock genes having different phases of circadian cycle of change in the amount of expression with regard to biological samples collected from an individual to be tested three times within 24 hours and predicting the biorhythm of the individual to be tested on the basis of obtained data of time series amount of expression. The method for predicting biorhythm includes predicting biorhythm especially with high precision by collecting biological samples from an individual to be tested three times at intervals of 8 hours within 24 hours.
COPYRIGHT: (C)2010,JPO&INPITAbstract translation: 要解决的问题：提供一种最小化来自待测试个体的生物样品的收集次数的方法，并以高精度预测生物节律。 用于预测待测个体的生物节律的方法包括测量从待测个体收集的生物样品的表达量的变化昼夜周期的不同阶段的两个时钟基因的表达量 在24小时内三次，并根据获得的时间序列表达数据预测待测个体的生物节律。 预测生物节律的方法包括通过从24小时内以8小时的间隔收集待测试的个体的三次生物样品，以高精度预测生物节律。 版权所有（C）2010，JPO＆INPIT
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6.发明专利
公开(公告)号：JP2009027952A
公开(公告)日：2009-02-12
申请号：JP2007193477
申请日：2007-07-25
Inventor： YAMAMOTO TAKUO , AKASHI MAKOTO , YAMASHITA YUKIISA , ABE TOMOTERU , NAKAGAWA KAZUHIRO , SOMA ATSUHIKO , NOIDE KOICHI , KISHII NORIYUKI , HAYAKAWA TOMOHIRO
CPC classification number: C12Q1/6881 , C12Q1/6876 , C12Q2600/158
Abstract: PROBLEM TO BE SOLVED: To provide a simple and low-invasive method for obtaining information on the biological rhythm in an individual organism. SOLUTION: The method for obtaining the information on the biological rhythm in the individual organism based on the change in expression level of a clock gene in a hair follicle cell in the individual organism over time is provided. According to the method, the phase shift in the biological rhythm in the individual organism can be detected by producing and checking a molecular clock table on the individual organism two or more times. Further, the phase shift in the biological rhythm in the individual organism can be detected by checking the expression level of the clock gene at a predetermined clock time against the molecular clock table. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供用于获得关于个体生物体中的生物节律的信息的简单且低侵入性的方法。 提供了基于个体生物体中的毛囊细胞中时钟基因的表达水平随时间的变化获得个体生物体中的生物节律信息的方法。 根据该方法，可以通过在个体生物体上生成和检查分子时钟表来检测个体生物体中的生物节律的相移两次或更多次。 此外，可以通过相对于分子时钟表在预定时钟时间检查时钟基因的表达水平来检测单个生物体中生物节律的相移。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2006273760A
公开(公告)日：2006-10-12
申请号：JP2005096459
申请日：2005-03-29
Inventor： YAMAMOTO TAKUO , MAMINE TAKAYOSHI , TAKUMI TORU , AKASHI MAKOTO
IPC: C07K14/47 , A61K31/7088 , A61K31/7105 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/00 , A61P25/20 , A61P35/00 , C12M1/00 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC classification number: A61K31/7105 , A61K31/7088 , C07K14/4702 , C07K14/70567 , G01N33/743 , G01N2333/70567 , G01N2500/00
Abstract: PROBLEM TO BE SOLVED: To elucidate unexplained parts of controlling mechanism of circadian rhythm.
SOLUTION: Promotion of expression inducement of Bmal1(brain-muscle ARNT-like protein 1) by RORα (retinoic acid receptor-related orphan receptor alpha) and promotion of expression inducement of Bmal1 in low oxygen state are newly found out. Existence of control mechanism of circadian rhythm that promotion of expression of RORα by the low oxygen state or the like promotes expression inducement of Bmal1 and the promotion of expression inducement of Bmal1 promotes bonding of Bmal1 with CLOCK and promotes expression inducement of Per gene or Cry gene, is much suggested thereby. So, application thereof as a jet lag conditioner or an anticancer agent is possible.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 要解决的问题：阐明昼夜节律控制机制的不明原因。 解决方案：新发现通过RORα（视黄酸受体相关孤儿受体α）促进Bmal1（脑 - 肌肉ARNT样蛋白1）的表达诱导和促进低氧状态下Bmal1的表达诱导。 存在昼夜节律的控制机制，促进低氧状态等的RORα表达促进Bmal1的表达诱导，促进Bmal1的表达诱导促进Bmal1与CLOCK的结合，促进Per基因或Cry基因的表达诱导 ，因此被大量的建议。 因此，作为喷射滞后调理剂或抗癌剂的应用是可能的。 版权所有（C）2007，JPO＆INPIT
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