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公开(公告)号：WO2006004833A2
公开(公告)日：2006-01-12
申请号：PCT/US2005023099
申请日：2005-06-28
Applicant: SQUIBB BRISTOL MYERS CO , BORZILLERI ROBERT M , CHEN ZHONG , HUNT JOHN T , HUYNH TRAM N , POSS MICHAEL A , SCHROEDER GRETCHEN M , VACCARO WAYNE , WONG TAI W , CHEN XIAO TAO , KIM KYOUNG S
Inventor： BORZILLERI ROBERT M , CHEN ZHONG , HUNT JOHN T , HUYNH TRAM N , POSS MICHAEL A , SCHROEDER GRETCHEN M , VACCARO WAYNE , WONG TAI W , CHEN XIAO TAO , KIM KYOUNG S
IPC: A61K31/53 , A61K31/519 , A61K31/52 , C07D471/04 , C07D473/14 , C07D487/02 , C07D487/04 , C07D495/04
CPC classification number: C07D471/04 , C07D473/00 , C07D473/30 , C07D487/04 , C07D495/04
Abstract: In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
Abstract translation: 通常，本发明包括式I和II化合物，包括其药学上可接受的盐。 本发明的化合物可用作蛋白激酶抑制剂，因此可用于治疗癌症和其他蛋白激酶介导的疾病。
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公开(公告)号：EP0626953A4
公开(公告)日：1995-05-03
申请号：EP94906439
申请日：1993-12-15
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： POSS MICHAEL A , MONIOT JEROME L , TRIFUNOVICH IVAN D , KUCERA DAVID J , THOTTATHIL JOHN K , CHEN SHU-HUI , WEI JIANMEI
IPC: C07C233/17 , A61K31/337 , A61K31/42 , A61P35/00 , C07C20060101 , C07C233/30 , C07C233/45 , C07C233/82 , C07C271/22 , C07C309/66 , C07C309/73 , C07D20060101 , C07D263/06 , C07D263/14 , C07D263/16 , C07D305/14 , C07D307/54 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F7/18
CPC classification number: C07D413/12 , C07C233/82 , C07C271/22 , C07D263/06 , C07D263/16 , C07D305/14 , C07D407/12 , C07D409/12 , C07D413/04 , C07D413/14 , Y02P20/55
Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
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公开(公告)号：EP1146871A4
公开(公告)日：2002-04-17
申请号：EP99968927
申请日：1999-12-21
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： POSS MICHAEL A , TORTOLANI DAVID R , MATTSON RONALD J , YEVICH JOSEPH P
IPC: A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/55 , A61P25/04 , A61P25/24 , C07D211/20 , C07D211/34 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , A61K31/385 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/4995 , A61K31/50 , C07D215/12 , C07D405/12
CPC classification number: C07D401/14 , C07D211/20 , C07D211/34 , C07D405/14 , C07D417/14
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4.发明公开CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD 失效KONFORMATIONSEINGESCHRÄNKTEAROMATISCHE INHIBITOREN DES MICROSOMALEN TRIGLYCERIDTRANSFERPROTEINS UND VERFAHREN
公开(公告)号：EP0904262A4
公开(公告)日：2000-10-04
申请号：EP97903805
申请日：1997-01-13
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： BILLER SCOTT A , DICKSON JOHN K , LAWRENCE R MICHAEL , MAGNIN DAVID R , POSS MICHAEL A , ROBL JEFFREY A , SLUSARCHYK WILLIAM A , SULSKY RICHARD B , TINO JOSEPH A
IPC: A61K31/00 , A61K31/191 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/39 , A61K31/40 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/4468 , A61K31/505 , A61K31/52 , A61K31/535 , C07C17/093 , C07C33/34 , C07C47/453 , C07C49/225 , C07C49/252 , C07C49/563 , C07C49/567 , C07C49/573 , C07C69/00 , C07C205/11 , C07C205/43 , C07C205/55 , C07C233/57 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C233/78 , C07C235/40 , C07C235/56 , C07C237/22 , C07C237/24 , C07C255/41 , C07C259/08 , C07C271/22 , C07C291/04 , C07C311/19 , C07C311/21 , C07C311/37 , C07C311/42 , C07C311/46 , C07C317/12 , C07C321/22 , C07C323/60 , C07D207/32 , C07D207/335 , C07D207/38 , C07D209/08 , C07D209/16 , C07D209/34 , C07D209/38 , C07D209/46 , C07D209/48 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/89 , C07D221/16 , C07D231/56 , C07D233/24 , C07D233/54 , C07D233/78 , C07D233/84 , C07D233/88 , C07D233/90 , C07D235/06 , C07D235/08 , C07D235/16 , C07D235/24 , C07D235/26 , C07D235/28 , C07D235/30 , C07D239/38 , C07D239/42 , C07D239/46 , C07D249/12 , C07D249/14 , C07D249/18 , C07D253/06 , C07D253/07 , C07D263/38 , C07D263/46 , C07D263/58 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/36 , C07D277/56 , C07D277/74 , C07D285/08 , C07D285/12 , C07D285/125 , C07D295/108 , C07D295/155 , C07D295/185 , C07D307/14 , C07D307/52 , C07D311/84 , C07D317/30 , C07D317/58 , C07D319/06 , C07D327/06 , C07D333/20 , C07D335/14 , C07D335/20 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07F7/18 , C07F9/40 , C07F9/58 , C07F9/59 , C07F9/6506 , C07F9/6533 , C07F9/655 , C07C217/04 , A61K31/24 , A61K31/47 , C07D401/08 , C07D403/08 , C07D471/10
CPC classification number: C07F7/1856 , A61K31/191 , A61K31/366 , A61K31/404 , A61K31/4468 , C07C17/093 , C07C47/453 , C07C49/563 , C07C49/567 , C07C49/573 , C07C69/00 , C07C205/11 , C07C205/43 , C07C205/55 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C233/78 , C07C235/40 , C07C235/56 , C07C237/22 , C07C237/24 , C07C255/41 , C07C259/08 , C07C271/22 , C07C291/04 , C07C311/19 , C07C311/21 , C07C311/37 , C07C311/42 , C07C311/46 , C07C317/12 , C07C321/22 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07C2603/00 , C07C2603/18 , C07C2603/32 , C07C2603/74 , C07D207/335 , C07D207/38 , C07D209/08 , C07D209/16 , C07D209/34 , C07D209/38 , C07D209/46 , C07D209/48 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/89 , C07D221/16 , C07D231/56 , C07D233/24 , C07D233/64 , C07D233/84 , C07D233/88 , C07D233/90 , C07D235/06 , C07D235/08 , C07D235/16 , C07D235/24 , C07D235/26 , C07D235/28 , C07D235/30 , C07D239/38 , C07D239/42 , C07D239/47 , C07D249/12 , C07D249/14 , C07D249/18 , C07D253/07 , C07D263/38 , C07D263/46 , C07D263/58 , C07D271/07 , C07D277/36 , C07D277/56 , C07D277/74 , C07D285/08 , C07D285/125 , C07D295/108 , C07D295/155 , C07D295/185 , C07D307/14 , C07D311/84 , C07D317/30 , C07D317/58 , C07D319/06 , C07D327/06 , C07D333/20 , C07D335/14 , C07D401/12 , C07D403/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07C25/22
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公开(公告)号：EP0886637A1
公开(公告)日：1998-12-30
申请号：EP96903604
申请日：1996-02-01
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： WETTERAU JOHN R II , SHARP DARU YOUNG , GREGG RICHARD E , BILLER SCOTT A , DICKSON JOHN A , LAWRENCE R MICHAEL , MAGNIN DAVID R , POSS MICHAEL A , ROBL JEFFREY A , SULSKY RICHARD B , TINO JOSEPH A , LAWSON JOHN E , HOLAVA HENRY M , PARTYKA RICHARD A
IPC: A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/52 , A61K31/535 , A61P3/06 , A61P9/10 , A61P43/00 , C07D211/00 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/94 , C07D211/98 , C07D215/38 , C07D217/00 , C07D217/22 , C07D221/16 , C07D241/04 , C07D401/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , C07D401/06 , C07D405/04 , C07D409/04
CPC classification number: C07D401/04 , C07D211/58 , C07D211/60 , C07D211/94 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , G01N2800/044
Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure (a, b, c or d) wherein R1 to R6, Q, and X are as defined herein.
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Patent Agency Ranking
公开(公告)号：EP1761268A4
公开(公告)日：2009-07-08
申请号：EP05791275
申请日：2005-06-28
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： BORZILLERI ROBERT M , CHEN ZHONG , HUNT JOHN T , HUYNH TRAM N , POSS MICHAEL A , SCHROEDER GRETCHEN M , VACCARO WAYNE , WONG TAI W , CHEN XIAO TAO , KIM KYOUNG S
IPC: A61K31/53 , A61K31/519 , A61K31/52 , A61P19/02 , A61P35/00 , C07D253/10 , C07D471/04 , C07D473/14 , C07D487/02 , C07D487/04 , C07D495/04
CPC classification number: C07D471/04 , C07D473/00 , C07D473/30 , C07D487/04 , C07D495/04
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7.发明公开AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES 有权AMINOTHIAZOLE ZUR HEMMUNGCYCLINABHÄNGIGERKINASEN
公开(公告)号：EP1042307A4
公开(公告)日：2003-01-29
申请号：EP98956431
申请日：1998-11-02
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： KIM KYOUNG S , KIMBALL S DAVID , POSS MICHAEL A , MISRA RAJ N , CAI ZHEN-WEI , RAWLINS DAVID B , WEBSTER KEVIN , HUNT JOHN T , HAN WEN-CHING
IPC: C07D277/20 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/506 , A61P1/04 , A61P9/00 , A61P9/10 , A61P9/14 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/06 , A61P43/00 , C07D263/00 , C07D277/00 , C07D277/42 , C07D277/44 , C07D277/54 , C07D417/12 , C07D417/14 , A61K31/425
CPC classification number: C07D417/14 , C07D417/12
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公开(公告)号：PL3218392T3
公开(公告)日：2021-01-11
申请号：PL15801052
申请日：2015-11-12
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： GILLMAN KEVIN W , GOODRICH JASON , BOY KENNETH M , ZHANG YUNHUI , MAPELLI CLAUDIO , POSS MICHAEL A , SUN LI-QIANG , ZHAO QIAN , MULL ERIC , GILLIS ERIC P , SCOLA PAUL MICHAEL , LANGLEY DAVID R , MEANWELL M NICHOLAS
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公开(公告)号：SI3218392T1
公开(公告)日：2020-11-30
申请号：SI201531374
申请日：2015-11-12
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： GILLMAN KEVIN W , GOODRICH JASON , BOY KENNETH M , ZHANG YUNHUI , MAPELLI CLAUDIO , POSS MICHAEL A , SUN LI-QIANG , ZHAO QIAN , MULL ERIC , GILLIS ERIC P , SCOLA PAUL MICHAEL , LANGLEY DAVID R , MEANWELL M NICHOLAS
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公开(公告)号：LT3218392T
公开(公告)日：2020-10-26
申请号：LT15801052
申请日：2015-11-12
Applicant: SQUIBB BRISTOL MYERS CO
Inventor： GILLMAN KEVIN W , GOODRICH JASON , BOY KENNETH M , ZHANG YUNHUI , MAPELLI CLAUDIO , POSS MICHAEL A , SUN LI-QIANG , ZHAO QIAN , MULL ERIC , GILLIS ERIC P , SCOLA PAUL MICHAEL , LANGLEY DAVID , MEANWELL M NICHOLAS
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