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    DEVICE, METHOD AND SYSTEM FOR PROVIDING VENTILATORY ASSIST TO A PATIENT
    2.
    发明申请
    DEVICE, METHOD AND SYSTEM FOR PROVIDING VENTILATORY ASSIST TO A PATIENT 审中-公开
    用于向患者提供通气辅助的装置，方法和系统

    公开(公告)号：WO2015095969A1

    公开(公告)日：2015-07-02

    申请号：PCT/CA2014/051260

    申请日：2014-12-23

    Applicant: ST. MICHAEL'S HOSPITAL

    Inventor： SINDERBY, Christer ,  BECK, Jennifer ,  COMTOIS, Norman

    IPC: A61M16/20 ,  A61M16/04 ,  A61M16/08

    CPC classification number: A61M16/0486 ,  A61M16/024 ,  A61M16/04 ,  A61M16/08 ,  A61M16/16 ,  A61M16/161 ,  A61M16/20 ,  A61M16/204 ,  A61M16/205 ,  A61M2016/0015 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/0208 ,  A61M2230/005 ,  A61M2230/08 ,  A61M2230/202 ,  A61M2230/432

    Abstract: A device for providing ventilatory assist to a patient is disclosed. The device comprises a manifold having an inspiratory port connectable to an inspiratory supply line, an interface port connectable to an external end of a tube inserted in a patient's trachea and an expiratory port configured to receive an expiratory flow from the tube via the interface port. An inspiratory lumen has a distal end insertable in the endotracheal tube towards its distal end. A cross-section of the inspiratory lumen is smaller than that of the endotracheal tube to allow gas flowing in the endotracheal tube independently from the inspiratory lumen. A valve is configured to direct an inspiratory flow from the inspiratory supply line to the inspiratory lumen, or to the endotracheal tube, or at once to the inspiratory lumen and to the endotracheal tube. A ventilatory assist system and method using the device are also disclosed.

    Abstract translation: 公开了一种用于向患者提供通气辅助的装置。 该装置包括具有可连接到吸气供应管线的吸气端口的歧管，可连接到插入患者气管中的管的外部端口的接口端口和被配置为经由接口端口从管道接收呼气流量的呼气端口。 吸气腔具有远端可插入到气管内管中的远端。 吸气腔的横截面小于气管内管的横截面，以允许气体独立于吸气腔流入气管内管。 阀被配置为将吸气流从吸气供应管线引导到吸气腔或气管内管，或者一次到吸气腔和气管内管。 还公开了使用该装置的通气辅助系统和方法。

    METHOD AND SYSTEM FOR QUANTIFYING TIMING DISCREPANCIES BETWEEN INSPIRATORY EFFORT AND VENTILATORY ASSIST
    3.
    发明申请
    METHOD AND SYSTEM FOR QUANTIFYING TIMING DISCREPANCIES BETWEEN INSPIRATORY EFFORT AND VENTILATORY ASSIST 审中-公开
    用于量化感觉作用与通气辅助之间的时间差异的方法和系统

    公开(公告)号：WO2013071404A1

    公开(公告)日：2013-05-23

    申请号：PCT/CA2012/001043

    申请日：2012-11-16

    Applicant: ST. MICHAEL'S HOSPITAL

    Inventor： SINDERBY, Christer ,  COMTOIS, Norman ,  BECK, Jennifer ,  EMTELL, Pär ,  KOCK, Michael

    IPC: A61B5/08 ,  A61B5/0488 ,  A61M16/00

    CPC classification number: A61M16/0051 ,  A61B5/04001 ,  A61B5/04884 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/742 ,  A61M16/0069 ,  A61M16/021 ,  A61M2016/0021 ,  A61M2205/502 ,  A61M2210/1014 ,  A61M2230/40 ,  A61M2230/60

    Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.

    Abstract translation: 本公开涉及一种用于量化吸气作用和通气辅助之间的时间差异的方法和系统。 通过将神经吸引的开始时间与通气辅助的开始时间进行比较来确定触发误差。 通过将神经吸引的结束时间与通气辅助的结束时间进行比较来确定循环关闭错误。 当触发错误低于第一阈值并且循环关闭错误低于第二阈值时，通气辅助被同步。 呼吸辅助的特征还可以是早期或晚期触发以及早期或晚期循环。 呼吸机的触发器可以根据触发误差进行调节，并且可以根据循环关闭错误来调整呼吸机的循环。

    METHOD AND SYSTEM FOR MEASURING CHANGES IN INSPIRATORY LOAD
    5.
    发明申请
    METHOD AND SYSTEM FOR MEASURING CHANGES IN INSPIRATORY LOAD 审中-公开
    用于测量感觉负荷变化的方法和系统

    公开(公告)号：WO2010081230A1

    公开(公告)日：2010-07-22

    申请号：PCT/CA2010/000056

    申请日：2010-01-15

    Applicant: ST. MICHAEL'S HOSPITAL ,  SINDERBY, Christer ,  BECK, Jennifer

    Inventor： SINDERBY, Christer ,  BECK, Jennifer

    IPC: A61B5/08 ,  A61B5/0488 ,  A61B5/091

    CPC classification number: A61B5/091 ,  A61B5/037 ,  A61B5/0488 ,  A61B5/087

    Abstract: A method and system for measuring changes in inspiratory load of a patient's respiratory system during mechanical ventilation. The method and system calculate a first relation between a measured inspiratory airway pressure and a measured electrical activity of respiratory muscle, and a second relation between a measured inspiratory volume and the measured electrical activity. A load index is calculated from the first and second relations. Changes in inspiratory load are determined based on the load index.

    Abstract translation: 一种用于测量机械通气期间患者呼吸系统吸气负荷变化的方法和系统。 方法和系统计算测量的吸气气道压力和测量的呼吸肌电活动之间的第一关系，以及测量的吸气体积与所测量的电活动之间的第二关系。 从第一关系和第二关系计算负荷指数。 根据负荷指数确定吸气负荷的变化。

    SYSTEMS, DEVICES AND METHODS FOR MODULATING A RESPIRATORY DRIVE OF A PATIENT
    6.
    发明申请
    SYSTEMS, DEVICES AND METHODS FOR MODULATING A RESPIRATORY DRIVE OF A PATIENT 审中-公开

    公开(公告)号：WO2020056511A1

    公开(公告)日：2020-03-26

    申请号：PCT/CA2019/051329

    申请日：2019-09-19

    Applicant: ST. MICHAEL'S HOSPITAL

    Inventor： SINDERBY, Christer ,  BECK, Jennifer ,  COMTOIS, Norman

    IPC: A61M16/00 ,  A61M16/10

    Abstract: A mechanical ventilation system comprises a plurality of ventilation therapy sub-systems. Each of the ventilation therapy sub-systems is adapted to assist a respiratory function of the patient. The system also comprises a detector of the respiratory drive of the patient, an operator interface receiving one or more control parameters, and a main controller. The main controller assigns a therapeutic contribution to each of the ventilation therapy sub-systems based on the respiratory drive of the patient and on the control parameters. The controller modulates the respiratory drive of a patient by controlling each of the plurality of the ventilation therapy sub-systems according to its assigned therapeutic contribution. Distinct ventilation therapy sub-systems may apply negative pressure on the abdomen of the patient, deliver a non-pressurizing inspiratory flow to the patient, or induce a positive pressure in the airways of the patient.

    DEVICE AND METHOD FOR CONTROLLING VENTILATORY ASSIST
    7.
    发明申请
    DEVICE AND METHOD FOR CONTROLLING VENTILATORY ASSIST 审中-公开
    用于控制通气辅助的装置和方法

    公开(公告)号：WO2017113017A1

    公开(公告)日：2017-07-06

    申请号：PCT/CA2016/051549

    申请日：2016-12-29

    Applicant: ST. MICHAEL'S HOSPITAL

    Inventor： SINDERBY, Christer ,  BECK, Jennifer ,  COMTOIS, Norman

    IPC: A61M16/00 ,  A61B5/08 ,  A61B5/091 ,  A61M16/10

    CPC classification number: A61B5/091 ,  A61M16/024 ,  A61M2016/0027 ,  A61M2016/0039

    Abstract: A device and method for controlling a level of ventilatory assist applied to a patient by a mechanical ventilator measures, during patient's assisted breath, an inspiratory volume V assist produced by both the patient and the mechanical ventilator, an inspiratory volume V vent contributed by the mechanical ventilator, and an inspiratory assist pressure P vent produced by the mechanical ventilator. A first relation between pressure P vent and volume V assist and a second relation between pressure P vent and volume V vent are calculated. Using the first and second relations, a ratio is determined between pressure P vent at volume V vent and pressure P vent at volume V assist , with volume V vent equal to volume V assist , for a plurality of volumes V vent and V assist . Values of P vent are multiplied by the corresponding calculated ratios to calculate a third relation between a predicted inspiratory pressure P pred and volume V assist. The mechanical ventilator is responsive to the third relation to control the level of ventilatory assist.

    Abstract translation: 用于在患者的辅助呼吸期间通过机械通气机控制施加到患者的通气辅助的水平的装置和方法在患者的辅助呼吸期间测量由患者的辅助呼吸产生的吸气体积V辅助 患者和机械呼吸机，由机械呼吸机产生的吸气体积V vent和由机械呼吸机产生的吸气辅助压力P vent。 压力P vent与体积V辅助之间的第一关系和压力P vent与体积V vent之间的第二关系计算。 使用第一和第二关系，确定体积V处的压力P vent和压力P vent N之间的比率。 具有等于​​体积V 辅助的体积V vent ，对于多个体积V vent 和V 辅助 。 将P vent的值乘以相应的计算比率以计算预测的吸气压力P pred和体积V assist之间的第三关系。 机械呼吸机响应第三个关系来控制通气辅助水平。

    METHOD AND DEVICE FOR DETERMINING A LEVEL OF VENTILATORY ASSIST TO A PATIENT
    9.
    发明申请
    METHOD AND DEVICE FOR DETERMINING A LEVEL OF VENTILATORY ASSIST TO A PATIENT 审中-公开
    用于确定患者的通气辅助水平的方法和装置

    公开(公告)号：WO2010081223A1

    公开(公告)日：2010-07-22

    申请号：PCT/CA2010/000043

    申请日：2010-01-14

    Applicant: ST. MICHAEL'S HOSPITAL ,  SINDERBY, Christer ,  BECK, Jennifer

    Inventor： SINDERBY, Christer ,  BECK, Jennifer

    IPC: A61M16/00 ,  A61B5/0448 ,  A61B5/08

    CPC classification number: A61M16/0051 ,  A61B5/0488 ,  A61B5/08 ,  A61M16/026 ,  A61M2016/0027

    Abstract: A method and device for determining a level of ventilatory assist to be delivered to a patient by a mechanical ventilator in response to a measure of a patient's neural respiratory drive multiplied by an amplification factor, wherein an existing predicted ventilatory assist pressure is calculated and an existing resulting pressure delivered to the patient by the mechanical ventilator is measured. The amplification factor is changed from an existing amplification factor to a new amplification factor, a new predicted ventilatory assist pressure is calculated using the new amplification factor, and a new resulting pressure delivered to the patient by the mechanical ventilator after the amplification factor has been changed is measured. The new and existing predicted ventilatory assist pressures are compared to determine an anticipated change in pressure that will be delivered to the patient, and the new and existing resulting pressures are compared to determine an actual change in pressure delivered to the patient by the mechanical ventilator. The anticipated and actual changes in pressure are compared and a decision to increase, maintain or decrease the amplification factor is delivered in response to the comparison between the anticipated change and the actual change in pressure.

    Abstract translation: 一种方法和装置，用于响应于患者的神经呼吸驱动器的乘积乘以放大系数来确定由机械呼吸机传送给患者的通气辅助水平，其中计算现有预测的通气辅助压力并存在现有的 测量由机械呼吸机输送给病人的压力。 放大因子从现有的放大因子改变为新的放大因子，使用新的放大因子计算新的预测的通气辅助压力，并且在放大因子被改变之后由机械呼吸机传递给患者的新的所得压力 被测量。 比较新的和现有的预测的通气辅助压力以确定将被递送给患者的预期压力变化，并且比较新的和现有的所得压力，以确定由机械呼吸机传递给患者的压力的实际变化。 比较压力的预期和实际变化，并响应于预期变化与实际压力变化之间的比较来提供增加，维持或降低放大系数的决定。

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