公开(公告)号：WO0168256A3

公开(公告)日：2002-06-27

申请号：PCT/US0108415

申请日：2001-03-16

Applicant: STANFORD RES INST INT

Inventor： PELRINE RONALD E ,  SHASTRI SUBRAMANIAN VENKAT ,  JOSEPH JOSE P

IPC: B81B7/02 ,  B01J19/00 ,  B01L3/00 ,  B01L99/00 ,  B81B1/00 ,  C12M1/00 ,  C40B40/06 ,  C40B40/10 ,  G01N35/00

CPC classification number: B01L3/50273 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00549 ,  B01J2219/00563 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00653 ,  B01J2219/00655 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01J2219/00871 ,  B01L3/0293 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0657 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/088 ,  B01L2400/043 ,  B01L2400/0475 ,  B01L2400/0484 ,  B01L2400/0633 ,  C40B40/06 ,  C40B40/10 ,  G01N35/0098 ,  G01N2035/00237

Abstract: Disclosed herein are apparatuses and devices, and methods for using and making the same, for use in performing desired activities in an automated, microscale format. Microparticles are ushered about within a microscale apparatus, to selectively move between various stations in a selected order and manner. Some embodiments include reaction, micro-weighing, micro-analysis, reagent acquisition and deposition, and incubation stations. Microparticles can individually move, or move as trains. Samples, including particulate and solid tissue samples may be manipulated and analyzed within the device. Some embodiments may engage in micro-fabrication activities or micro-deconstruction activities. Systems for controlling such apparatuses are included as well as methods of operation.

Abstract translation: 本文公开了用于使用和制造它们的装置和装置以及用于以自动化的微型格式执行所需活动的方法。 在微型设备中引入微粒，以选择的顺序和方式选择性地在各个站之间移动。 一些实施方案包括反应，微量称重，微量分析，试剂获取和沉积以及孵化站。 微粒可以单独移动或作为火车移动。 可以在装置内操纵和分析样品，包括颗粒和固体组织样品。 一些实施例可以参与微制造活动或微解构活动。 包括用于控制这些装置的系统以及操作方法。

公开(公告)号：EP1461796A4

公开(公告)日：2006-11-15

申请号：EP02807998

申请日：2002-10-31

Applicant: STANFORD RES INST INT

Inventor： AGUERO VICTOR M ,  JOSEPH JOSE P ,  BRACKMANN ELIZABETH J ,  HOLLAND CHRISTOPHER E ,  SPINDT CHARLES A ,  SCHWOEBEL PAUL R ,  PEARSON ERIC M

IPC: G01N37/00 ,  G09G3/10 ,  B01J19/00 ,  B01L3/02 ,  G01N30/72 ,  G01N35/10

CPC classification number: B01L3/0268 ,  B01L2300/0819 ,  B01L2400/027 ,  B01L2400/0415 ,  G01N30/7266

Abstract: A fluid-dispensing device comprises substrate (212) and a plurality of nozzles (204) formed in the substrate (212). Each nozzle has (204) has an open-ended tip and a fluid-conducting channel (220) between the tip and a source of fluid. A non-conducting spacer is on the substrate (212) and electrically isolates a gate electrode (208) from the substrate (212). The gate electrode is located adjacent to the tip of at least one of the nozzles (204) to effect dispensing of the fluid in that nozzle (204) in response to a voltage applied between the gate electrode (208) and the nozzle (204) or fluid in the nozzle (204). The gate electrode (208) includes a plurality of individually addressable gate electrodes used for selectively actuating nozzles (204).

公开(公告)号：EP1221180A4

公开(公告)日：2004-09-15

申请号：EP00959149

申请日：2000-07-20

Applicant: STANFORD RES INST INT

Inventor： PELRINE RONALD E ,  KORNBLUH ROY D ,  PEI QIBING ,  OH SEAJIN ,  JOSEPH JOSE P

IPC: H01L41/08 ,  F04B35/00 ,  F04B35/04 ,  F04B43/04 ,  H01L41/047 ,  H01L41/09 ,  H01L41/113 ,  H01L41/193 ,  H01L41/45 ,  H04R19/02 ,  H04R23/00 ,  H01L41/04

CPC classification number: H01L41/0536 ,  F02G2243/52 ,  F04B35/00 ,  F04B35/045 ,  F04B43/043 ,  F05C2225/08 ,  H01L41/094 ,  H01L41/0973 ,  H01L41/0986 ,  H01L41/193 ,  H01L41/45 ,  H02N2/023 ,  H04R19/02 ,  H04R23/00

Abstract: The present invention relates to electroactive polymers (152) that are pre-strained to improve conversion from electrical to mechanical energy. When a voltage is applied to electrodes (156) contacting a pre-strained polymer (152), the polymer (152) deflects. This deflection may be used to do mechanical work. The pre-strain improves the mechanical response of an electroactive polymer (152). The present invention also relates to actuators including an electroactive polymer and mechanical coupling to convert deflection of the polymer into mechanical work. The present invention further relates to compliant electrodes that conform to the shape of a polymer. The present invention provides methods for fabrication electromechanical devices including one or more electroactive polymers.

Abstract translation: 本发明涉及预先应变的电活性聚合物（152），以改善从电能到机械能的转换。 当电压施加到接触预应变聚合物（152）的电极（156）时，聚合物（152）偏转。 这种偏转可以用来做机械功。 预应变改善了电活性聚合物（152）的机械响应。 本发明还涉及包括电活性聚合物和机械联接的致动器，以将聚合物的偏转转换成机械功。 本发明还涉及符合聚合物形状的柔性电极。 本发明提供了用于制造包括一种或多种电活性聚合物的机电装置的方法。

公开(公告)号：WO2004067708A2

公开(公告)日：2004-08-12

申请号：PCT/US2004001034

申请日：2004-01-16

Applicant: STANFORD RES INST INT ,  KNAPP MERRILL A ,  AGUERO VICTOR M ,  JOSEPH JOSE P ,  LADEROUTE KEITH R ,  HEYDT RICHARD P ,  MCCLOSKEY RACHEL

Inventor： KNAPP MERRILL A ,  AGUERO VICTOR M ,  JOSEPH JOSE P ,  LADEROUTE KEITH R ,  HEYDT RICHARD P ,  MCCLOSKEY RACHEL

IPC: C12N15/10 ,  C12N

CPC classification number: B01L3/5021 ,  B01L3/5027 ,  B01L2400/0633 ,  B01L2400/0683 ,  B01L2400/086 ,  C12N15/10 ,  C12N15/1003 ,  G01N1/286

Abstract: A device and method for use with a centrifuge for fragmenting solute or particulate material contained in a liquid sample are disclosed. The device includes a substrate adapted to be supported within a centrifuge tube, and providing a microchannel defining a plurality of shear regions. Material contained in a liquid sample applied to the device, with such supported in a centrifuge tube within a centrifuge, is fragmented by shearing as the sample is forced successively through the plurality of shear regions in the microchannel, when the selected centrifugal force applied to the tube.

Abstract translation: 公开了一种与离心机一起使用以将包含在液体样品中的溶质或微粒材料碎裂的装置和方法。 该装置包括适于被支撑在离心管内的基板，以及提供限定多个剪切区域的微通道。 通过剪切使应用于装置的液体样品中所含有的液体样品中的物质通过剪切而被分段，当样品被强制依次通过微通道中的多个剪切区域时，当选择的离心力施加到 管。

公开(公告)号：WO0106579A8

公开(公告)日：2002-08-22

申请号：PCT/US0019950

申请日：2000-07-20

Applicant: STANFORD RES INST INT

Inventor： PELRINE RONALD E ,  KORNBLUH ROY D ,  PEI QIBING ,  OH SEAJIN ,  JOSEPH JOSE P

IPC: H01L41/08 ,  F04B35/00 ,  F04B35/04 ,  F04B43/04 ,  H01L41/047 ,  H01L41/09 ,  H01L41/113 ,  H01L41/193 ,  H01L41/45 ,  H04R19/02 ,  H04R23/00 ,  H01L41/04

CPC classification number: H01L41/0536 ,  F02G2243/52 ,  F04B35/00 ,  F04B35/045 ,  F04B43/043 ,  F05C2225/08 ,  H01L41/094 ,  H01L41/0973 ,  H01L41/0986 ,  H01L41/193 ,  H01L41/45 ,  H02N2/023 ,  H04R19/02 ,  H04R23/00

Abstract: The present invention relates to electroactive polymers (152) that are pre-strained to improve conversion from electrical to mechanical energy. When a voltage is applied to electrodes (156) contacting a pre-strained polymer (152), the polymer (152) deflects. This deflection may be used to do mechanical work. The pre-strain improves the mechanical response of an electroactive polymer (152). The present invention also relates to actuators including an electroactive polymer and mechanical coupling to convert deflection of the polymer into mechanical work. The present invention further relates to compliant electrodes that conform to the shape of a polymer. The present invention provides methods for fabrication electromechanical devices including one or more electroactive polymers.

Abstract translation: 本发明涉及预应变以提高从电到机械能的转化的电活性聚合物（152）。 当电压施加到与预应变聚合物（152）接触的电极（156）时，聚合物（152）偏转。 该偏转可用于进行机械作业。 预应变改善了电活性聚合物（152）的机械响应。 本发明还涉及包括电活性聚合物和机械耦合以将聚合物的偏转转化为机械加工的致动器。 本发明还涉及符合聚合物形状的顺应性电极。 本发明提供了制造包括一种或多种电活性聚合物的机电装置的方法。

公开(公告)号：WO2016049243A9

公开(公告)日：2016-05-06

申请号：PCT/US2015051803

申请日：2015-09-23

Applicant: STANFORD RES INST INT

Inventor： HOFIUS JONATHAN ,  JOSEPH JOSE P ,  KOTHARI MANISH ,  GARCIA KILROY PABLO E

IPC: A61M25/00

CPC classification number: A61B5/1486 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/6852

Abstract: Devices, systems and methods for measuring, and configured to measure, a blood analyte continuously or at intervals, the device comprising at least a first set of analyte sensing sensor electrodes configured for making electrochemical measurements of the analyte, and at least a second set of biofouling prevention electrodes in operable proximity to, and configured to prevent biofouling of, the first set of electrodes.

Abstract translation: 用于测量和配置为测量血液分析物的装置，系统和方法，其连续地或间隔地进行，该装置包括被配置用于进行分析物的电化学测量的至少第一组分析物感测传感器电极，以及至少第二组 生物污垢防止电极可操作地接近并被构造成防止第一组电极的生物污损。

公开(公告)号：WO0106579A3

公开(公告)日：2002-01-31

申请号：PCT/US0019950

申请日：2000-07-20

Applicant: STANFORD RES INST INT

Inventor： PELRINE RONALD E ,  KORNBLUH ROY D ,  PEI QIBING ,  OH SEAJIN ,  JOSEPH JOSE P

IPC: H01L41/08 ,  F04B35/00 ,  F04B35/04 ,  F04B43/04 ,  H01L41/047 ,  H01L41/09 ,  H01L41/113 ,  H01L41/193 ,  H01L41/45 ,  H04R19/02 ,  H04R23/00 ,  H01L41/04

CPC classification number: H01L41/0536 ,  F02G2243/52 ,  F04B35/00 ,  F04B35/045 ,  F04B43/043 ,  F05C2225/08 ,  H01L41/094 ,  H01L41/0973 ,  H01L41/0986 ,  H01L41/193 ,  H01L41/45 ,  H02N2/023 ,  H04R19/02 ,  H04R23/00

Abstract: The present invention relates to electroactive polymers (152) that are pre-strained to improve conversion from electrical to mechanical energy. When a voltage is applied to electrodes (156) contacting a pre-strained polymer (152), the polymer (152) deflects. This deflection may be used to do mechanical work. The pre-strain improves the mechanical response of an electroactive polymer (152). The present invention also relates to actuators including an electroactive polymer and mechanical coupling to convert deflection of the polymer into mechanical work. The present invention further relates to compliant electrodes that conform to the shape of a polymer. The present invention provides methods for fabricating electromechanical devices including one or more electroactive polymers.

Abstract translation: 本发明涉及预应变以提高从电到机械能的转化的电活性聚合物（152）。 当电压施加到与预应变聚合物（152）接触的电极（156）时，聚合物（152）偏转。 该偏转可用于进行机械作业。 预应变改善了电活性聚合物（152）的机械响应。 本发明还涉及包括电活性聚合物和机械耦合以将聚合物的偏转转化为机械加工的致动器。 本发明还涉及符合聚合物形状的顺应性电极。 本发明提供了制造包括一种或多种电活性聚合物的机电装置的方法。

公开(公告)号：DK1221180T3

公开(公告)日：2010-12-20

申请号：DK00959149

申请日：2000-07-20

Applicant: STANFORD RES INST INT

Inventor： PELRINE RONALD E ,  OH SEAJIN ,  JOSEPH JOSE P ,  KORNBLUH ROY D ,  PEI QIBING

IPC: H01L41/08 ,  H01L41/09 ,  F04B35/00 ,  F04B35/04 ,  F04B43/04 ,  H01L41/047 ,  H01L41/113 ,  H01L41/193 ,  H01L41/45 ,  H04R19/02 ,  H04R23/00

公开(公告)号：PT1848046E

公开(公告)日：2012-12-17

申请号：PT07015635

申请日：2000-07-20

Applicant: STANFORD RES INST INT

Inventor： PELRINE RONALD E ,  KORNBLUH ROY D ,  PEI QIBING ,  JOSEPH JOSE P

IPC: H01L41/08 ,  H01L41/09 ,  F04B35/00 ,  F04B35/04 ,  F04B43/04 ,  H01L41/047 ,  H01L41/113 ,  H01L41/193 ,  H01L41/45 ,  H02N2/02 ,  H04R19/02 ,  H04R23/00

公开(公告)号：CA2837726C

公开(公告)日：2016-09-20

申请号：CA2837726

申请日：2012-06-20

Applicant: STANFORD RES INST INT ,  UNIV LELAND STANFORD JUNIOR

Inventor： JOSEPH JOSE P ,  GARCIA PABLO E ,  SHAKESPEAR KAREN F ,  YOUNG SARAH ,  HAAGENSEN JANUS A J ,  DUTTA SANJEEV

IPC: A61L29/04 ,  A61L2/03 ,  A61L12/02 ,  A61L29/14 ,  A61M25/00 ,  A61N1/20 ,  A61N1/36 ,  A61N1/378

Abstract: An implantable catheter is provided that may be disinfected without removal from the body of a patient, using an electrochemical method to generate an electric field on the catheter surface and thus destroy microorganisms in a biofilm that is present or forming. A catheter system includes the implantable catheter and a voltage source that is operably connected to electrodes on or embedded in the exterior and optionally the interior catheter surface. Methods are also provided for disinfecting the implantable catheter in vivo and for detecting or confirming the presence of a pathogenic biofilm thereon.