公开(公告)号：WO2010014827A3

公开(公告)日：2010-04-29

申请号：PCT/US2009052277

申请日：2009-07-30

Applicant: STC UNM ,  SMYTH HUGH D C ,  DONOVAN MARTIN

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 µm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

Abstract translation: 干粉吸入器可以包括药物腔室，该药物腔室构造成容纳包括载体颗粒和工作剂颗粒的制剂，构造成引导工作剂颗粒流向使用者的嘴部和靠近嘴部件的保持构件。 保持构件的尺寸和布置被设置成防止基本上所有载体颗粒流向使用者，同时允许工作剂颗粒流向使用者。 吸入器可以包括含有载体颗粒的制剂，用于将工作剂递送至患者的肺部系统。 载体颗粒可具有大于约500μm的平均筛直径。 载体颗粒可以是聚苯乙烯，PTFE，硅酮玻璃，硅胶或玻璃中的一种。

公开(公告)号：WO2011112756A2

公开(公告)日：2011-09-15

申请号：PCT/US2011027797

申请日：2011-03-09

Applicant: STC UNM ,  SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

Inventor： SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: B05B7/14 ,  B05B7/02 ,  B05B7/24 ,  B05B15/00

CPC classification number: B05B7/144 ,  A61M15/0028 ,  A61M15/0065 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2205/0238 ,  B05B13/0207 ,  B05B15/0443

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

Abstract translation: 用于将干燥粉末微粒涂覆到表面上的装置包括喷射式粉碎机，其被配置为将干燥粉末颗粒研磨成具有期望空气动力学直径的微粒并使微粒解聚，构造并布置成将干燥粉末颗粒送入喷射式粉碎机的进料斗， 表面构造成接收干粉微粒和与喷射磨相关联的出口喷嘴。 出口喷嘴可以布置成将来自喷射磨机的解聚集的微粉化干粉颗粒引导到待涂覆的表面。 该装置还可以包括构造和布置成保持物品的保持器，其中物品包括表面。 在设备的某些方面，该项目可以是电影。

公开(公告)号：EP2328556A4

公开(公告)日：2013-11-20

申请号：EP09803599

申请日：2009-07-30

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

公开(公告)号：AU2011224397A1

公开(公告)日：2012-09-06

申请号：AU2011224397

申请日：2011-03-09

Applicant: STC UNM

Inventor： SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: B05B7/14 ,  B05B7/02 ,  B05B7/24 ,  B05B15/00

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

公开(公告)号：CA2789674A1

公开(公告)日：2011-09-15

申请号：CA2789674

申请日：2011-03-09

Applicant: STC UNM

Inventor： SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: B05B7/14 ,  B05B7/02 ,  B05B7/24 ,  B05B15/00

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

公开(公告)号：CA2732585A1

公开(公告)日：2010-02-04

申请号：CA2732585

申请日：2009-07-30

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 µm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

公开(公告)号：AU2009276498A1

公开(公告)日：2010-02-04

申请号：AU2009276498

申请日：2009-07-30

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.