公开(公告)号：WO2010014827A3

公开(公告)日：2010-04-29

申请号：PCT/US2009052277

申请日：2009-07-30

Applicant: STC UNM ,  SMYTH HUGH D C ,  DONOVAN MARTIN

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 µm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

Abstract translation: 干粉吸入器可以包括药物腔室，该药物腔室构造成容纳包括载体颗粒和工作剂颗粒的制剂，构造成引导工作剂颗粒流向使用者的嘴部和靠近嘴部件的保持构件。 保持构件的尺寸和布置被设置成防止基本上所有载体颗粒流向使用者，同时允许工作剂颗粒流向使用者。 吸入器可以包括含有载体颗粒的制剂，用于将工作剂递送至患者的肺部系统。 载体颗粒可具有大于约500μm的平均筛直径。 载体颗粒可以是聚苯乙烯，PTFE，硅酮玻璃，硅胶或玻璃中的一种。

公开(公告)号：WO2011112756A2

公开(公告)日：2011-09-15

申请号：PCT/US2011027797

申请日：2011-03-09

Applicant: STC UNM ,  SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

Inventor： SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: B05B7/14 ,  B05B7/02 ,  B05B7/24 ,  B05B15/00

CPC classification number: B05B7/144 ,  A61M15/0028 ,  A61M15/0065 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2205/0238 ,  B05B13/0207 ,  B05B15/0443

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

Abstract translation: 用于将干燥粉末微粒涂覆到表面上的装置包括喷射式粉碎机，其被配置为将干燥粉末颗粒研磨成具有期望空气动力学直径的微粒并使微粒解聚，构造并布置成将干燥粉末颗粒送入喷射式粉碎机的进料斗， 表面构造成接收干粉微粒和与喷射磨相关联的出口喷嘴。 出口喷嘴可以布置成将来自喷射磨机的解聚集的微粉化干粉颗粒引导到待涂覆的表面。 该装置还可以包括构造和布置成保持物品的保持器，其中物品包括表面。 在设备的某些方面，该项目可以是电影。

公开(公告)号：WO2011031564A3

公开(公告)日：2011-07-14

申请号：PCT/US2010047043

申请日：2010-08-27

Applicant: STC UNM ,  SMYTH HUGH D C ,  DONOVAN MARTIN J

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN J

IPC: A61K9/28 ,  A61K9/12 ,  A61K9/14

CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.

Abstract translation: 将粉末状药剂涂覆到用于干粉吸入器的载体颗粒上的方法可包括将超声波能量应用于聚集粉末药剂以将药剂颗粒解聚并雾化成具有期望平均粒度的颗粒， 至少一种载体颗粒与期望量的药物的解聚和雾化颗粒。

公开(公告)号：WO2011112531A3

公开(公告)日：2012-01-05

申请号：PCT/US2011027465

申请日：2011-03-08

Applicant: STC UNM ,  MAYNARD NICOLA JEANNE ,  SMYTH HUGH D C

Inventor： MAYNARD NICOLA JEANNE ,  SMYTH HUGH D C

IPC: A61M11/02 ,  A61J1/05 ,  A61M15/00

CPC classification number: A61M15/0086 ,  A61M11/003 ,  A61M15/00 ,  A61M15/0006 ,  A61M15/0021 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/009 ,  A61M2016/0015 ,  A61M2202/064 ,  A61M2205/0272 ,  A61M2205/8287 ,  A61M2206/16

Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically- responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

Abstract translation: 干粉递送装置可以被配置为向使用者的气道提供微粉化的干粉颗粒。 该装置可以包括限定包含至少一个磁响应物体的腔室的圆柱形容器，在该腔室外部的电动机，该腔室外部的磁体并与该电动机可旋转地联接，以及流出部件，其将气流引导至使用者 。 磁性响应物体可以涂覆有微粉化的干粉末颗粒，并且电动机可操作以使磁体围绕轴线旋转。 磁体的旋转产生磁场，使得响应于磁场的磁响应物体移动并与容器的侧壁碰撞，以使干粉颗粒解聚并使空腔中的干粉雾化。

公开(公告)号：WO2011060334A3

公开(公告)日：2011-09-22

申请号：PCT/US2010056628

申请日：2010-11-12

Applicant: STC UNM ,  SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

Inventor： SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

IPC: A61M15/00 ,  A61M11/02

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2206/16

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

Abstract translation: 一种干粉吸入器，包括限定用于接收一定剂量的粉末药物的腔室的壳体，与腔室流体连通的吸入口，至少一个气流入口，其提供腔室与外壳之间的流体连通，以及颤动元件 并且与一定剂量的粉末状药物相关联。 颤振元件具有靠近至少一个气流入口的张紧的远端和与入口的远端和下游相对的自由近端。 颤振元件构造成响应于通过腔室的气流而振动并使粉末状药物的剂量雾化。

公开(公告)号：WO2005104712A3

公开(公告)日：2007-06-07

申请号：PCT/US2005014010

申请日：2005-04-22

Applicant: CYDEX INC ,  PIPKIN JAMES D ,  ZIMMERER RUPERT O ,  HICKEY ANTHONY J ,  THOMPSON DIANE O ,  SMYTH HUGH D C

Inventor： PIPKIN JAMES D ,  ZIMMERER RUPERT O ,  HICKEY ANTHONY J ,  THOMPSON DIANE O ,  SMYTH HUGH D C

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/14 ,  A61K47/40 ,  C08B37/16

CPC classification number: A61K47/40 ,  A61K9/0075 ,  Y10T428/2982

Abstract: An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.

Abstract translation: 提供含有SAE-CD和活性剂的可吸入干粉配方。 该制剂适用于DPI的给药。 SAE-CD作为载体而不是吸收增强剂。 SAE-CD的平均粒径足够大以排除（大部分）肺沉积。 从DPI装置释放后，含有SAE-CD的颗粒从颊腔或咽喉中的含活性剂颗粒分离，之后含活性剂的颗粒继续深入呼吸道。 SAE-CD的物理化学和形态学特性易于修饰，可以优化活性剂和载体的相互作用。 当使用SAE-CD作为载体时，具有正，中性或负静电电荷的药物可由DPI递送。

公开(公告)号：WO2006047663A2

公开(公告)日：2006-05-04

申请号：PCT/US2005038713

申请日：2005-10-26

Applicant: UNIV NORTH CAROLINA ,  HICKEY ANTHONY J ,  SMYTH HUGH D C

Inventor： HICKEY ANTHONY J ,  SMYTH HUGH D C

IPC: B05B1/24

CPC classification number: A61M15/00 ,  A61M11/041 ,  A61M11/042

Abstract: An apparatus for generating an aerosol of a therapeutic agent and methods of using the same are disclosed. The apparatus comprises a heating element having a surface and a composition coating at least a portion of the heating element surface. The composition comprises a carrier and a therapeutic agent, wherein when the heating element surface is heated to at least the vaporization point of the carrier, the carrier vaporizes and releases the therapeutic agent from the composition as an aerosol. The heating element can be a coiled filament. The therapeutic agent can be a small molecule, a polynucleotide, a polypeptide, or a recombinant virus. The apparatus can be incorporated into a delivery device, such as a metered dose inhaler or an exposure chamber.

Abstract translation: 公开了一种用于产生治疗剂的气溶胶的装置及其使用方法。 该装置包括具有表面和组合物涂覆至少部分加热元件表面的加热元件。 组合物包含载体和治疗剂，其中当将加热元件表面加热至至少载体的蒸发点时，载体以气雾剂的形式蒸发并释放治疗剂。 加热元件可以是螺旋丝。 治疗剂可以是小分子，多核苷酸，多肽或重组病毒。 该装置可以并入输送装置，例如计量剂量吸入器或曝光室。

公开(公告)号：WO2006047660A3

公开(公告)日：2006-06-29

申请号：PCT/US2005038698

申请日：2005-10-26

Applicant: UNIV NORTH CAROLINA ,  HICKEY ANTHONY J ,  MITRAN SORIN M ,  SMYTH HUGH D C

Inventor： HICKEY ANTHONY J ,  MITRAN SORIN M ,  SMYTH HUGH D C

IPC: A61K9/12 ,  A61K9/14 ,  G01N1/10

CPC classification number: A61M15/009 ,  A61M11/001 ,  B05B17/0607

Abstract: Methods of modulating a characteristic of a pharmaceutical compound spray by acoustic measurement and control of the pharmaceutical spray are disclosed. The methods include analyzing a selected characteristic of a pharmaceutical compound spray utilizing acoustic measurement to develop corresponding acoustic data. The methods further include controlling the selected characteristic by applying acoustic excitation to the pharmaceutical compound spray in accordance with the acoustic data developed.

Abstract translation: 公开了通过声学测量和药物喷雾的控制来调节药物化合物喷雾特性的方法。 所述方法包括使用声学测量来分析药物化合物喷雾的选定特征，以形成相应的声学数据。 所述方法还包括根据所开发的声学数据，通过向药物化合物喷雾施加声学激发来控制所选择的特征。

公开(公告)号：EP2470167A4

公开(公告)日：2013-08-14

申请号：EP10815900

申请日：2010-08-27

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN J

IPC: A61K9/28 ,  A61K9/12 ,  A61K9/14

CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

公开(公告)号：CA2779488A1

公开(公告)日：2011-05-19

申请号：CA2779488

申请日：2010-11-12

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

IPC: A61M15/00 ,  A61M11/02

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.