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公开(公告)号：WO2003003003A3
公开(公告)日：2003-01-09
申请号：PCT/US2002/020669
申请日：2002-06-28
Applicant: SYMYX TECHNOLOGIES, INC.
Inventor： FRANK, Trevor, G. , HALL, Keith, A. , CHANDLER, William, H , BOUSSIE, Thomas , CREVIER, Thomas, J. , MATSIEV, Leonid , GOH, Christopher
IPC: G01N31/00
Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber is disclosed, The apparatus includes a reaction chamber for receiving one or more libraries, each of the libraries comprising two or more samples. The reaction chamber is configured to form a sealed enclosure. The apparatus further includes an injection manifold supporting injectors for in-situ injection of one or more chemical components onto respective samples of the one or more libraries in the pressurized sealed reaction chamber.
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公开(公告)号：WO2003003003A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/020669
申请日：2002-06-28
Applicant: SYMYX TECHNOLOGIES, INC.
Inventor： FRANK, Trevor, G. , HALL, Keith, A. , CHANDLER, William, H , BOUSSIE, Thomas , CREVIER, Thomas, J. , MATSIEV, Leonid , GOH, Christopher
IPC: G01N31/00
CPC classification number: G01N31/10 , B01J19/0046 , G01N25/72 , G01N35/025 , G01N2035/00188 , Y10T436/10 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/114165 , Y10T436/25
Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber is disclosed, The apparatus includes a reaction chamber for receiving one or more libraries, each of the libraries comprising two or more samples. The reaction chamber is configured to form a sealed enclosure. The apparatus further includes an injection manifold supporting injectors for in-situ injection of one or more chemical components onto respective samples of the one or more libraries in the pressurized sealed reaction chamber.
Abstract translation: 公开了一种用于将一种或多种化学组分原位注入反应室的设备。该设备包括用于接收一个或多个文库的反应室，每个文库包括两个或更多个样本 。 反应室构造成形成密封外壳。 该设备还包括注射歧管，该注射歧管支撑用于将一种或多种化学成分原位注射到加压密封的反应室中的一个或多个文库的相应样品上的注射器。
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公开(公告)号：EP0950114A1
公开(公告)日：1999-10-20
申请号：EP98934381.0
申请日：1998-07-10
Applicant: SYMYX TECHNOLOGIES
Inventor： BOUSSIE, Thomas , MURPHY, Vince , VAN BEEK, Johannes, A., M. , DEVENNEY, Martin , TURNER, Howard, W. , POWERS, Timothy
CPC classification number: B01J19/00 , C07B61/00 , C12Q1/68 , G01N33/53 , G01N33/543
Abstract: The present invention discloses methods and materials for constructing combinatorial libraries composed of organometallic compounds immobilized on solid supports and encoded with detectable tags. The encoded library of organometallic compound is especially useful for rapidly screening large numbers of member compounds for catalytic performance. These immobilized catalysts can be pooled in a single reactor where they are screened for a predefined property, such as catalytic activity and selectivity.
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Patent Agency Ranking4.发明授权
公开(公告)号：EP0923590B1
公开(公告)日：2001-10-10
申请号：EP97934335.7
申请日：1997-07-22
Applicant: SYMYX TECHNOLOGIES
Inventor： WEINBERG, W., Henry , McFARLAND, Eric , GOLDWASSER, Isy , BOUSSIE, Thomas , TURNER, Howard , VAN BEEK, Johannes, A., M. , MURPHY, Vince , POWERS, Timothy
CPC classification number: G01N29/348 , B01J19/0046 , B01J2219/00317 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00738 , B01J2219/00745 , B01J2219/0075 , B01J2219/00754 , C07F15/0066 , C07F15/045 , C08F10/00 , C08F110/02 , C40B40/18 , C40B60/14 , G01N29/0681 , G01N29/2418 , G01N2291/106 , Y10T436/2575 , C08F4/7006 , C08F4/027 , C08F2500/03 , C08F4/7081
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公开(公告)号：EP0920436A1
公开(公告)日：1999-06-09
申请号：EP98926102.0
申请日：1998-05-28
Applicant: SYMYX TECHNOLOGIES
Inventor： BOUSSIE, Thomas , HALL, Keith, A. , LaPOINTE, Anne, M. , MURPHY, Vince , POWERS, Timothy , VAN BEEK, Johannes, A., M.
Abstract: Delivery and scavenging agents are provided for the combinatorial synthesis of organometallic compounds in a solution or suspension, where the agents are constructed from a solid support allowing for easy separation of unreacted reagents or unwanted materials from a synthesis reaction. Use of these solid supported agents also allows otherwise unfavorable reactions to be driven to completion by the use of large excesses of reactants and minimizes the chances for competing bimolecular side reactions in parallel or rapid serial synthesis.
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公开(公告)号：EP1399737A2
公开(公告)日：2004-03-24
申请号：EP02761023.7
申请日：2002-06-28
Applicant: Symyx Technologies, Inc.
Inventor： FRANK, Trevor, G. , HALL, Keith, A. , CHANDLER, William, H , BOUSSIE, Thomas , CREVIER, Thomas, J. , MATSIEV, Leonid , GOH, Christopher
IPC: G01N31/00
CPC classification number: G01N31/10 , B01J19/0046 , G01N25/72 , G01N35/025 , G01N2035/00188 , Y10T436/10 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/114165 , Y10T436/25
Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber is disclosed, The apparatus includes a reaction chamber for receiving one or more libraries, each of the libraries comprising two or more samples. The reaction chamber is configured to form a sealed enclosure. The apparatus further includes an injection manifold supporting injectors for in-situ injection of one or more chemical components onto respective samples of the one or more libraries in the pressurized sealed reaction chamber.
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公开(公告)号：EP1000074A1
公开(公告)日：2000-05-17
申请号：EP98935824.7
申请日：1998-07-20
Applicant: SYMYX TECHNOLOGIES
Inventor： BOUSSIE, Thomas , MURPHY, Vince , VAN BEEK, Johannes, A., M.
CPC classification number: C07F15/045 , C07F13/00 , C07F13/005 , C07F15/0086 , C07F15/02 , C07F15/025 , C07F15/04 , C07F15/06 , C07F15/065 , C08F10/00 , C08F110/02 , Y10S526/943 , C08F4/7022 , C08F4/7054 , C08F4/7031 , C08F4/7021 , C08F4/7055 , C08F4/69284 , C08F4/7029
Abstract: Novel compositions and metal compounds having an ancillary ligand structure polymerize monomers and functionalized monomers, either alone or in the presence of an activator. The ancillary ligand structure is a chelating ligand that may optionally be further bound to the metal via a dative or covalent bond.
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8.发明公开COMBINATORIAL SYNTHESIS AND ANALYSIS OF ORGANOMETALLIC COMPOUNDS AND CATALYSTS 无效组合合成和有机金属化合物和催化剂的分析
公开(公告)号：EP0923590A1
公开(公告)日：1999-06-23
申请号：EP97934335.0
申请日：1997-07-22
Applicant: SYMYX TECHNOLOGIES
Inventor： WEINBERG, W., Henry , McFARLAND, Eric , GOLDWASSER, Isy , BOUSSIE, Thomas , TURNER, Howard , VAN BEEK, Johannes, A., M. , MURPHY, Vince , POWERS, Timothy
IPC: B01J23 , B01J19 , B01J31 , B01J37 , C07B61 , C07C249 , C07C251 , C07D213 , C07F15 , C07F19 , C08F4 , C08F10 , C40B40 , C40B50 , G01N21 , G01N29 , C40B60
CPC classification number: G01N29/348 , B01J19/0046 , B01J2219/00317 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00738 , B01J2219/00745 , B01J2219/0075 , B01J2219/00754 , C07F15/0066 , C07F15/045 , C08F10/00 , C08F110/02 , C40B40/18 , C40B60/14 , G01N29/0681 , G01N29/2418 , G01N2291/106 , Y10T436/2575 , C08F4/7006 , C08F4/027 , C08F2500/03 , C08F4/7081
Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.
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