公开(公告)号：EP0950114A1

公开(公告)日：1999-10-20

申请号：EP98934381.0

申请日：1998-07-10

Applicant: SYMYX TECHNOLOGIES

Inventor： BOUSSIE, Thomas ,  MURPHY, Vince ,  VAN BEEK, Johannes, A., M. ,  DEVENNEY, Martin ,  TURNER, Howard, W. ,  POWERS, Timothy

IPC: B01J19 ,  C07B61 ,  C12Q1 ,  G01N33

CPC classification number: B01J19/00 ,  C07B61/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/543

Abstract: The present invention discloses methods and materials for constructing combinatorial libraries composed of organometallic compounds immobilized on solid supports and encoded with detectable tags. The encoded library of organometallic compound is especially useful for rapidly screening large numbers of member compounds for catalytic performance. These immobilized catalysts can be pooled in a single reactor where they are screened for a predefined property, such as catalytic activity and selectivity.

公开(公告)号：EP0923590A1

公开(公告)日：1999-06-23

申请号：EP97934335.0

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES

Inventor： WEINBERG, W., Henry ,  McFARLAND, Eric ,  GOLDWASSER, Isy ,  BOUSSIE, Thomas ,  TURNER, Howard ,  VAN BEEK, Johannes, A., M. ,  MURPHY, Vince ,  POWERS, Timothy

IPC: B01J23 ,  B01J19 ,  B01J31 ,  B01J37 ,  C07B61 ,  C07C249 ,  C07C251 ,  C07D213 ,  C07F15 ,  C07F19 ,  C08F4 ,  C08F10 ,  C40B40 ,  C40B50 ,  G01N21 ,  G01N29 ,  C40B60

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：EP0923590B1

公开(公告)日：2001-10-10

申请号：EP97934335.7

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES

Inventor： WEINBERG, W., Henry ,  McFARLAND, Eric ,  GOLDWASSER, Isy ,  BOUSSIE, Thomas ,  TURNER, Howard ,  VAN BEEK, Johannes, A., M. ,  MURPHY, Vince ,  POWERS, Timothy

IPC: C07F19/00 ,  C07F15/00 ,  C07B61/00 ,  C08F4/70

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

公开(公告)号：EP0920436A1

公开(公告)日：1999-06-09

申请号：EP98926102.0

申请日：1998-05-28

Applicant: SYMYX TECHNOLOGIES

Inventor： BOUSSIE, Thomas ,  HALL, Keith, A. ,  LaPOINTE, Anne, M. ,  MURPHY, Vince ,  POWERS, Timothy ,  VAN BEEK, Johannes, A., M.

IPC: B01J19 ,  C07B61 ,  C07F19

CPC classification number: B01J19/00 ,  C07B61/00 ,  C07F19/00

Abstract: Delivery and scavenging agents are provided for the combinatorial synthesis of organometallic compounds in a solution or suspension, where the agents are constructed from a solid support allowing for easy separation of unreacted reagents or unwanted materials from a synthesis reaction. Use of these solid supported agents also allows otherwise unfavorable reactions to be driven to completion by the use of large excesses of reactants and minimizes the chances for competing bimolecular side reactions in parallel or rapid serial synthesis.