公开(公告)号：WO2008143739A2

公开(公告)日：2008-11-27

申请号：PCT/US2008/004200

申请日：2008-03-31

Applicant: SYMYX TECHNOLOGIES, INC. ,  DIAMOND, Gary, M. ,  HALL, Keith, A. ,  McWAID, Thomas, Harding ,  MURPHY, Vince ,  MYSLOVATY, Michael ,  SHOEMAKER, James, A., W. ,  SIDHU, Robbie, Singh ,  TURNER, Howard ,  DIAS, Eric ,  SPITKOVSKY, Mikhail

Inventor： DIAMOND, Gary, M. ,  HALL, Keith, A. ,  McWAID, Thomas, Harding ,  MURPHY, Vince ,  MYSLOVATY, Michael ,  SHOEMAKER, James, A., W. ,  SIDHU, Robbie, Singh ,  TURNER, Howard ,  DIAS, Eric ,  SPITKOVSKY, Mikhail

IPC: B01J19/00 ,  C40B60/14

CPC classification number: C40B60/14 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00389 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/0072 ,  B01J2219/00736 ,  F16K27/003

Abstract: In one embodiment, a parallel batch reactor for effecting chemical reactions includes a vessel block comprising reactor vessels for receiving components of a reaction and a valve block removably attached to the vessel block. The valve block includes a first plurality of valves in fluid communication with an inlet port for supplying pressurized fluid to the reactor vessels and configured to fluidically isolate one or more of the reactor vessels from at least one of the other reactor vessels. The valve block further includes a second plurality of valves in fluid communication with the reactor vessels for injecting chemical components into the pressurized reactor vessels or sampling chemical components from the pressurized reactor vessels. The vessel block and valve block are configured to sustain an operating pressure of at least 15 psig.

Abstract translation: 在一个实施方案中，用于实现化学反应的并行批量反应器包括容器块，其包含用于接收反应组分的反应器容器和可移除地附接到容器块的阀块。 阀块包括与入口端口流体连通的第一多个阀，用于将加压流体供应到反应器容器并且构造成将一个或多个反应器容器与至少一个其它反应器容器进行流体隔离。 阀块还包括与反应器容器流体连通的第二多个阀，用于将化学组分注入加压反应器容器或从加压反应器容器取样化学组分。 容器块和阀块被配置为维持至少15psig的操作压力。

公开(公告)号：EP0923590A1

公开(公告)日：1999-06-23

申请号：EP97934335.0

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES

Inventor： WEINBERG, W., Henry ,  McFARLAND, Eric ,  GOLDWASSER, Isy ,  BOUSSIE, Thomas ,  TURNER, Howard ,  VAN BEEK, Johannes, A., M. ,  MURPHY, Vince ,  POWERS, Timothy

IPC: B01J23 ,  B01J19 ,  B01J31 ,  B01J37 ,  C07B61 ,  C07C249 ,  C07C251 ,  C07D213 ,  C07F15 ,  C07F19 ,  C08F4 ,  C08F10 ,  C40B40 ,  C40B50 ,  G01N21 ,  G01N29 ,  C40B60

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：EP1069942B1

公开(公告)日：2003-05-28

申请号：EP99942147.2

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： TURNER, Howard ,  DALES, G., Cameron ,  VAN ERDEN, Lynn ,  VAN BEEK, Johannes, A., M. ,  HAJDUK, Damian, A. ,  NIELSEN, Ralph, B. ,  MANSKY, Paul ,  MATSIEV, Leonid ,  WANG, Pei ,  McFARLAND, Eric

IPC: B01J19/00

CPC classification number: G01N21/253 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F15/00454 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  Y10T436/11

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：EP0923590B1

公开(公告)日：2001-10-10

申请号：EP97934335.7

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES

Inventor： WEINBERG, W., Henry ,  McFARLAND, Eric ,  GOLDWASSER, Isy ,  BOUSSIE, Thomas ,  TURNER, Howard ,  VAN BEEK, Johannes, A., M. ,  MURPHY, Vince ,  POWERS, Timothy

IPC: C07F19/00 ,  C07F15/00 ,  C07B61/00 ,  C08F4/70

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

公开(公告)号：EP1069942A1

公开(公告)日：2001-01-24

申请号：EP99942147.2

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： TURNER, Howard ,  DALES, G., Cameron ,  VAN ERDEN, Lynn ,  VAN BEEK, Johannes, A., M. ,  HAJDUK, Damian, A. ,  NIELSEN, Ralph, B. ,  MANSKY, Paul ,  MATSIEV, Leonid ,  WANG, Pei ,  McFARLAND, Eric

IPC: B01J19/00

CPC classification number: G01N21/253 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F15/00454 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  Y10T436/11

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.