公开(公告)号：WO1998014641A1

公开(公告)日：1998-04-09

申请号：PCT/US1997017682

申请日：1997-09-30

Applicant: SYMYX TECHNOLOGIES

Inventor： SYMYX TECHNOLOGIES ,  McFARLAND, Eric ,  DANIELSON, Earl ,  DEVENNEY, Martin ,  WARREN, Christopher, J.

IPC: C25D05/02

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00371 ,  B01J2219/00436 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00686 ,  B01J2219/00702 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00752 ,  B01J2219/00754 ,  B01J2219/00756 ,  B01L3/0241 ,  B01L3/5085 ,  C25D5/02 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  H01F1/404 ,  H01F41/34

Abstract: Methods and apparatus are provided for the preparation of a substrate having an array of diverse materials, the materials being deposited at spatially addressable, predefined regions. In particular, potential masking systems are provided which generate spatially and temporally varying electric, magnetic and chemical potentials across a substrate. These varying potentials are used to deposit components of source materials onto a substrate in a combinatorial fashion, thus creating arrays of materials that differ slightly in chemical composition, concentration, stoichiometry, and/or thickness. The diverse materials may be organized in discrete arrays, or they may vary continuously over the surface of the substrate. The shape of the potential allows the determination of the composition of the resulting materials at all locations on the substrate.

Abstract translation: 提供了用于制备具有不同材料阵列的基材的方法和装置，该材料沉积在空间可寻址的预定区域。 特别地，提供了潜在的掩蔽系统，其在衬底上产生空间和时间上变化的电，磁和化学势。 这些变化的电位用于以组合的方式将源材料的成分沉积到衬底上，从而产生化学组成，浓度，化学计量和/或厚度略有不同的材料阵列。 不同的材料可以以离散阵列组织，或者它们可以在衬底的表面上连续变化。 电位的形状允许确定所得材料在基底上所有位置的组成。

公开(公告)号：EP0943091A1

公开(公告)日：1999-09-22

申请号：EP98949736.0

申请日：1998-10-02

Applicant: SYMYX TECHNOLOGIES

Inventor： MATSIEV, Leonid ,  BENNETT, James ,  McFARLAND, Eric

IPC: G01H13 ,  G01N5 ,  G01N9 ,  G01N29 ,  H03H9

CPC classification number: G01N29/4418 ,  B01J2219/00704 ,  G01H13/00 ,  G01N5/04 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/348 ,  G01N29/42 ,  G01N2009/006 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties.

公开(公告)号：EP0923590A1

公开(公告)日：1999-06-23

申请号：EP97934335.0

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES

Inventor： WEINBERG, W., Henry ,  McFARLAND, Eric ,  GOLDWASSER, Isy ,  BOUSSIE, Thomas ,  TURNER, Howard ,  VAN BEEK, Johannes, A., M. ,  MURPHY, Vince ,  POWERS, Timothy

IPC: B01J23 ,  B01J19 ,  B01J31 ,  B01J37 ,  C07B61 ,  C07C249 ,  C07C251 ,  C07D213 ,  C07F15 ,  C07F19 ,  C08F4 ,  C08F10 ,  C40B40 ,  C40B50 ,  G01N21 ,  G01N29 ,  C40B60

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：EP1069942B1

公开(公告)日：2003-05-28

申请号：EP99942147.2

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： TURNER, Howard ,  DALES, G., Cameron ,  VAN ERDEN, Lynn ,  VAN BEEK, Johannes, A., M. ,  HAJDUK, Damian, A. ,  NIELSEN, Ralph, B. ,  MANSKY, Paul ,  MATSIEV, Leonid ,  WANG, Pei ,  McFARLAND, Eric

IPC: B01J19/00

CPC classification number: G01N21/253 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F15/00454 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  Y10T436/11

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：EP0943091B1

公开(公告)日：2003-05-02

申请号：EP98949736.7

申请日：1998-10-02

Applicant: Symyx Technologies, Inc.

Inventor： MATSIEV, Leonid ,  BENNETT, James ,  McFARLAND, Eric

IPC: G01N29/02 ,  G01N9/00

CPC classification number: G01N29/4418 ,  B01J2219/00704 ,  G01H13/00 ,  G01N5/04 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/348 ,  G01N29/42 ,  G01N2009/006 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

公开(公告)号：EP0923590B1

公开(公告)日：2001-10-10

申请号：EP97934335.7

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES

Inventor： WEINBERG, W., Henry ,  McFARLAND, Eric ,  GOLDWASSER, Isy ,  BOUSSIE, Thomas ,  TURNER, Howard ,  VAN BEEK, Johannes, A., M. ,  MURPHY, Vince ,  POWERS, Timothy

IPC: C07F19/00 ,  C07F15/00 ,  C07B61/00 ,  C08F4/70

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

公开(公告)号：EP1069942A1

公开(公告)日：2001-01-24

申请号：EP99942147.2

申请日：1999-08-12

Applicant: Symyx Technologies, Inc.

Inventor： TURNER, Howard ,  DALES, G., Cameron ,  VAN ERDEN, Lynn ,  VAN BEEK, Johannes, A., M. ,  HAJDUK, Damian, A. ,  NIELSEN, Ralph, B. ,  MANSKY, Paul ,  MATSIEV, Leonid ,  WANG, Pei ,  McFARLAND, Eric

IPC: B01J19/00

CPC classification number: G01N21/253 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01F15/00454 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  Y10T436/11

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.