公开(公告)号：JP2008224686A

公开(公告)日：2008-09-25

申请号：JP2008140198

申请日：2008-05-28

Applicant: Symyx Technologies Inc ,  サイミックス テクノロジーズ, インコーポレイテッド

Inventor： CARLSON ERIC D ,  CONG PEIJUN ,  CHANDLER WILLIAM H JR ,  CHAU HENRY K ,  DANIELSON EARL ,  DESROSIERS PETER J ,  DOOLAN ROBERT D ,  WU LUPING

IPC: G01N21/64 ,  G01N33/50 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L7/00 ,  C07B61/00 ,  C07D209/20 ,  C07D293/00 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  G01N5/04 ,  G01N13/00 ,  G01N21/23 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/47 ,  G01N21/65 ,  G01N21/78 ,  G01N24/08 ,  G01N25/04 ,  G01N30/88 ,  G01N33/15 ,  G01N33/483 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: PROBLEM TO BE SOLVED: To provide a methods, an apparatus, and a system for performing a high-throughput preparation and a screening of salts and polymorphs of drug candidates. SOLUTION: The method is directed toward enhancing the pre-formulation discovery process used for a drug development. In particular, processes of determining suitable salts and processes of discovering substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members from, for example, a library model generated by a computer system. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供用于进行药物候选物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 解决方案：该方法旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定合适的盐和基本上发现可以从特定药物候选物形成的每个多晶型物的过程的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为从例如由计算机系统生成的库模型合成多个库成员。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2002316042A

公开(公告)日：2002-10-29

申请号：JP2002019230

申请日：2002-01-28

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DALES G CAMERON ,  DIAMOND GARY M ,  FRANK TREVOR G ,  FREITAG CHRISTOPHER J ,  HIGASHIHARA KENNETH S ,  MURPHY VINCE ,  TROTH JONAH R ,  CHANDLER WILLIAM H JR ,  HUFFMAN DAVE

IPC: B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B25J9/02 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: PROBLEM TO BE SOLVED: To provide a parallel reactor system suitable for the handling of fluid substances containing slurry substance and to provide a method concerning the same. SOLUTION: The parallel reactor system is provided with a reactor 9, a vessel to be placed in the reactor and holding a reaction mixture and a cannula for introducing fluid reaction substances to the vessel. A robot system 23 enables the operation of inserting the cannula into a cannula path in the reactor 9 for conveying the reactant containing the slurry to a corresponding vessel and pulling off the cannula from the cannula path after the conveyance. The related method and the cannula design are also disclosed.

公开(公告)号：DE60211760D1

公开(公告)日：2006-07-06

申请号：DE60211760

申请日：2002-01-21

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DALES G CAMERON ,  TROTH JONAH R ,  HIGASHIHARA KENNETH S ,  DIAMOND GARY ,  MURPHY VINCE ,  CHANDLER WILLIAM H JR ,  FRANK TREVOR G ,  FREITAG J CHRISTOPHER ,  HUFFMAN DAVE

IPC: B01J19/00 ,  B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01L3/00 ,  B01L7/00 ,  B25J9/02 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: A method of preparing and delivering a slurry into a series of vessels in a reactor, said method comprising: (1) mixing a particulate solid material and a liquid dispersing medium and agitating the mixture to form a substantially homogeneous first slurry in which said particulate solid material is suspended in the liquid; (2) aspirating said first slurry into a cannula carried by a robot system while the slurry is substantially homogeneous; (3) operating the robot system to insert the cannula into the reactor;(4) delivering the slurry from the cannula into the vessel while the cannula is in said reactor; and (5) repeating (2)-(4) for a second vessel with said first slurry or repeating (2)-(4) for a second vessel with a second slurry.

公开(公告)号：CA2369222C

公开(公告)日：2006-06-20

申请号：CA2369222

申请日：2002-01-23

Applicant: SYMYX TECHNOLOGIES INC

Inventor： FREITAG J CHRISTOPHER ,  DALES G CAMERON ,  HIGASHIHARA KENNETH S ,  FRANK TREVOR G ,  TROTH JONAH R ,  DIAMOND GARY M ,  HUFFMAN DAVE ,  CHANDLER WILLIAM H JR ,  MURPHY VINCE

IPC: B01J19/00 ,  B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J8/14 ,  B01L3/00 ,  B01L7/00 ,  B08B3/00 ,  B25J9/02 ,  B25J11/00 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including slurries, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods and cannula designs are also disclosed.

公开(公告)号：DE60211760T2

公开(公告)日：2007-05-24

申请号：DE60211760

申请日：2002-01-21

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DALES G CAMERON ,  TROTH JONAH R ,  HIGASHIHARA KENNETH S ,  DIAMOND GARY ,  MURPHY VINCE ,  CHANDLER WILLIAM H JR ,  FRANK TREVOR G ,  FREITAG J CHRISTOPHER ,  HUFFMAN DAVE

IPC: B01J19/00 ,  B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01L3/00 ,  B01L7/00 ,  B25J9/02 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: A method of preparing and delivering a slurry into a series of vessels in a reactor, said method comprising: (1) mixing a particulate solid material and a liquid dispersing medium and agitating the mixture to form a substantially homogeneous first slurry in which said particulate solid material is suspended in the liquid; (2) aspirating said first slurry into a cannula carried by a robot system while the slurry is substantially homogeneous; (3) operating the robot system to insert the cannula into the reactor;(4) delivering the slurry from the cannula into the vessel while the cannula is in said reactor; and (5) repeating (2)-(4) for a second vessel with said first slurry or repeating (2)-(4) for a second vessel with a second slurry.

公开(公告)号：CA2538983A1

公开(公告)日：2002-07-26

申请号：CA2538983

申请日：2002-01-23

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HIGASHIHARA KENNETH S ,  TROTH JONAH R ,  FREITAG J CHRISTOPHER ,  FRANK TREVOR G ,  DIAMOND GARY M ,  CHANDLER WILLIAM H JR ,  MURPHY VINCE ,  DALES G CAMERON ,  HUFFMAN DAVE

IPC: B01J8/20 ,  B25J11/00

Abstract: A method of preparing and delivering a slurry into a series of vessels in a reactor. The method comprises (1) mixing a particulate solid material and a liquid dispersing medium and agitating the mixture to form a substantially homogeneous first slurry in which the particulate solid material is suspended in the liquid; (2) aspirating the first slurry into a cannula carried by a robot system while the slurry is substantially homogeneous; (3) operating the robot system to insert the cannula into the reactor; (4) delivering the slurry from the cannula into the vessel while the cannula is in the reactor; and, (5) repeating (2)-(4) for a second vessel with the first slurr y or repeating (2)-(4) for a second vessel with a second slurry.

公开(公告)号：CA2369222A1

公开(公告)日：2002-07-26

申请号：CA2369222

申请日：2002-01-23

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HIGASHIHARA KENNETH S ,  MURPHY VINCE ,  DALES G CAMERON ,  FRANK TREVOR G ,  DIAMOND GARY M ,  FREITAG J CHRISTOPHER ,  TROTH JONAH R ,  CHANDLER WILLIAM H JR ,  HUFFMAN DAVE

IPC: B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B25J9/02 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  B08B3/00 ,  B25J11/00 ,  B01J8/14

Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including slurries, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods and cannula designs are also disclosed.

公开(公告)号：AT327824T

公开(公告)日：2006-06-15

申请号：AT02001451

申请日：2002-01-21

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DALES G CAMERON ,  TROTH JONAH R ,  HIGASHIHARA KENNETH S ,  DIAMOND GARY ,  MURPHY VINCE ,  CHANDLER WILLIAM H JR ,  FRANK TREVOR G ,  FREITAG J CHRISTOPHER ,  HUFFMAN DAVE

IPC: B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B25J9/02 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: A method of preparing and delivering a slurry into a series of vessels in a reactor, said method comprising: (1) mixing a particulate solid material and a liquid dispersing medium and agitating the mixture to form a substantially homogeneous first slurry in which said particulate solid material is suspended in the liquid; (2) aspirating said first slurry into a cannula carried by a robot system while the slurry is substantially homogeneous; (3) operating the robot system to insert the cannula into the reactor;(4) delivering the slurry from the cannula into the vessel while the cannula is in said reactor; and (5) repeating (2)-(4) for a second vessel with said first slurry or repeating (2)-(4) for a second vessel with a second slurry.

公开(公告)号：AU2003210536A1

公开(公告)日：2003-11-17

申请号：AU2003210536

申请日：2003-01-16

Applicant: SYMYX TECHNOLOGIES INC

Inventor： ERDEN LYNN VAN ,  CHANDLER WILLIAM H JR

IPC: B01J3/04 ,  B01J19/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14

Abstract: An apparatus and method for synthesis and screening of materials are disclosed. According to one aspect of the present invention, a parallel batch reactor for effecting chemical reactions includes a pressure chamber, an inlet port, two or more reaction vessels within the pressure chamber, and a reaction vessel cover. The inlet port is in fluid communication with the pressure chamber, and pressurizes the pressure chamber from an external pressure source. Each of the two or more reaction vessels are in isolatable fluid communication with the pressure chamber such that during a first pressurizing stage of operation, each of the two or more reaction vessels can be simultaneously pressurized through common fluid communication with the pressure chamber. In addition, during at least a second reaction stage of operation, each of the two or more pressurized reaction vessels can be isolated from each other by positioning the reaction vessel cover appropriately.

公开(公告)号：WO02081076A3

公开(公告)日：2003-04-24

申请号：PCT/US0210935

申请日：2002-04-04

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WHEELER TONY H ,  VAN ERDEN LYNN ,  CHANDLER WILLIAM H JR ,  TIEDE RICHARD ,  SAXTON ROBERT J ,  GURAM ANIL

IPC: B01J19/00 ,  C40B60/14 ,  F28F27/00

CPC classification number: F28F27/00 ,  B01J19/0046 ,  B01J2219/00155 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00698 ,  B01J2219/00718 ,  C40B60/14 ,  Y10T436/11 ,  Y10T436/142222

Abstract: A combinatorial chemistry reactor system for the parallel processing of reaction mixtures. The system comprises a frame, a head mounted in fixed position on the frame, and a reactor block having a plurality of wells therein for containing reaction mixtures. The reactor block is movable with respect to the head between a first position in which the reactor block and head are assembled for conducting reactions in the wells and a second position in which the reactor block is removed from the head for providing access to the vessels. Gaps in the reactor block between the wells serve to thermally isolate the wells from one another. Other features relating to pressure relief, reactor block temperature control, and sensor mounting are also disclosed.

Abstract translation: 用于并行处理反应混合物的组合化学反应器系统。 该系统包括框架，安装在框架上的固定位置的头部和反应器块，其中具有用于容纳反应混合物的多个孔。 反应器模块可相对于头部在第一位置和第二位置之间相对于第一位置移动，在第一位置，反应器块和头组装在其中以在井中进行反应，而在第二位置，反应器块从头部移除以提供对容器的通路。 两个井之间的反应器块中的间隙用于将孔彼此热隔离。 还公开了与减压，反应堆块温度控制和传感器安装相关的其它特征。