公开(公告)号：JP2008224686A

公开(公告)日：2008-09-25

申请号：JP2008140198

申请日：2008-05-28

Applicant: Symyx Technologies Inc ,  サイミックス テクノロジーズ, インコーポレイテッド

Inventor： CARLSON ERIC D ,  CONG PEIJUN ,  CHANDLER WILLIAM H JR ,  CHAU HENRY K ,  DANIELSON EARL ,  DESROSIERS PETER J ,  DOOLAN ROBERT D ,  WU LUPING

IPC: G01N21/64 ,  G01N33/50 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L7/00 ,  C07B61/00 ,  C07D209/20 ,  C07D293/00 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  G01N5/04 ,  G01N13/00 ,  G01N21/23 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/47 ,  G01N21/65 ,  G01N21/78 ,  G01N24/08 ,  G01N25/04 ,  G01N30/88 ,  G01N33/15 ,  G01N33/483 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: PROBLEM TO BE SOLVED: To provide a methods, an apparatus, and a system for performing a high-throughput preparation and a screening of salts and polymorphs of drug candidates. SOLUTION: The method is directed toward enhancing the pre-formulation discovery process used for a drug development. In particular, processes of determining suitable salts and processes of discovering substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members from, for example, a library model generated by a computer system. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供用于进行药物候选物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 解决方案：该方法旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定合适的盐和基本上发现可以从特定药物候选物形成的每个多晶型物的过程的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为从例如由计算机系统生成的库模型合成多个库成员。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：AU5909499A

公开(公告)日：2000-03-27

申请号：AU5909499

申请日：1999-09-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DESROSIERS PETER J ,  DUBE CHRISTOPHER E ,  ZHOU XIAO PING

IPC: B01J19/00 ,  B01L3/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N31/10 ,  G01N33/00 ,  G01N31/02

公开(公告)号：AT266866T

公开(公告)日：2004-05-15

申请号：AT99946758

申请日：1999-09-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DESROSIERS PETER J ,  DUBE CHRISTOPHER E ,  ZHOU XIAO PING

IPC: B01J19/00 ,  B01L3/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N31/10 ,  G01N33/00 ,  G01N31/02

公开(公告)号：CA2307617A1

公开(公告)日：2000-03-16

申请号：CA2307617

申请日：1999-09-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DUBE CHRISTOPHER E ,  DESROSIERS PETER J ,  ZHOU XIAO PING

IPC: B01J19/00 ,  B01L3/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N31/10 ,  G01N33/00 ,  G01N31/02

Abstract: Methods and devices for rapidly analyzing groups of reactions aredisclosed. The method includes the steps of contacting a fluid sample from one of the reaction mixtures with a sorbent, trapping at least one component of the fluid sample on the sorbent, and detecting the at least one component of the fluid sample trapped on the sorbent. The contacting step, the trapping step, and the detecting step are carried out at least once for each of the reaction mixtures in rapid serial or parallel fashion. The present invention is useful for screening combinatorial libraries, especially libraries of catalysts made through parallel synthesis, but the disclosed methods and devices can be used to analyze a broad spectrum of chemical transformations.

公开(公告)号：WO2004078131A3

公开(公告)日：2005-01-20

申请号：PCT/US2004006327

申请日：2004-03-01

Applicant: SYMYX TECHNOLOGIES INC ,  CARLSON ERIC D ,  DESROSIERS PETER J ,  SONG LI

Inventor： CARLSON ERIC D ,  DESROSIERS PETER J ,  SONG LI

IPC: A61K20060101 ,  B01J19/00 ,  G01N33/15 ,  G01N33/53 ,  G01N33/543 ,  G01N35/00

CPC classification number: G01N33/15 ,  B01J2219/00599 ,  B01J2219/00686 ,  B01J2219/00702 ,  B01J2219/00756 ,  C40B60/12

Abstract: The present invention relates to the field of research for drug formulations. More particularly, this invention is directed toward an apparatus and method of performing parallel synthesis and screening of multiple drug compositions for stability and compatibility when exposed to various conditions over time, including various environmental and/or chemical conditions. In one aspect, the invention includes a method of testing for effects of a condition on a drug sample. The method includes providing an array of drug samples, simultaneously exposing a first plurality of the drug samples in the array to a first controlled condition for a period of time within an exposure period, and evaluating a plurality of the exposed drug samples at a first time and a second time using a non-destructive test in order to determine whether the condition has an affect on one or more of the drug samples over time. At least a portion of the exposure period between said first and second time, and the non-destructive test is the same each time.

Abstract translation: 本发明涉及药物制剂的研究领域。 更具体地，本发明涉及当暴露于包括各种环境和/或化学条件在内的各种条件时，在多种药物组合物中进行平行合成和筛选以确保稳定性和相容性的装置和方法。 一方面，本发明包括测试病症对药物样品的影响的方法。 该方法包括提供药物样品阵列，同时将阵列内的第一组多个药物样品暴露于暴露期内的一段时间内的第一受控状态，以及第一次评估多个暴露的药物样品 并且第二次使用非破坏性测试来确定条件是否随着时间对一种或多种药物样品产生影响。 所述第一次和第二次之间的曝光期间的至少一部分与无损检测每次相同。

公开(公告)号：EP1425577A4

公开(公告)日：2004-12-29

申请号：EP02731970

申请日：2002-05-24

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CARLSON ERIC D ,  CONG PEIJUN ,  CHANDLER WILLIAM H JR ,  CHAU HENRY K ,  DANIELSON EARL ,  DESROSIERS PETER J ,  DOOLAN ROBERT D ,  WU LUPING

IPC: G01N21/64 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L7/00 ,  C07B61/00 ,  C07D209/20 ,  C07D293/00 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  G01N5/04 ,  G01N13/00 ,  G01N21/23 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/47 ,  G01N21/65 ,  G01N21/78 ,  G01N24/08 ,  G01N25/04 ,  G01N30/88 ,  G01N33/15 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00 ,  G01N33/48

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymporphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system.