公开(公告)号：JP2002241388A

公开(公告)日：2002-08-28

申请号：JP2001378681

申请日：2001-12-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG W HENRY ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BUSHY THOMAS ,  TURNER HOWARD ,  VAN BEEK JOHANNES A M ,  MURPHY VINCE ,  POWERS TIMOTHY

IPC: B01J23/22 ,  B01J19/00 ,  B01J31/22 ,  B01J37/00 ,  C07B61/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F19/00 ,  C08F4/70 ,  C08F10/00 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

Abstract: PROBLEM TO BE SOLVED: To provide a method for the synthesis, screening and characterization of an organic metal compound and a catalyst (for example, a homogeneous catalyst). SOLUTION: A method for producing an array of a carried metal ligand compound, which enables the measurement of at least one change of a ligand core, the identity of the substituent of the ligand core, the electric charge of a metal ion, a counter ion, an activating substance, reaction conditions, a solvent, additives, and a linker, comprises disposing the first metal ligand compound and the second metal ligand compound different from the first metal ligand compound, carried on a carrier different from the substrate, thus forming the combinatorial array of the metal ligand compounds carried at a space.

公开(公告)号：JP2002241387A

公开(公告)日：2002-08-28

申请号：JP2001378680

申请日：2001-12-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG W HENRY ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BUSHY THOMAS ,  TURNER HOWARD ,  VAN BEEK JOHANNES A M ,  MURPHY VINCE ,  POWERS TIMOTHY

IPC: B01J23/22 ,  B01J19/00 ,  B01J31/22 ,  B01J37/00 ,  C07B61/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F19/00 ,  C08F4/70 ,  C08F10/00 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

Abstract: PROBLEM TO BE SOLVED: To provide a method for the synthesis, screening and characterization of an organic metal compound and a catalyst (for example, a homogeneous catalyst). SOLUTION: A method for producing an array of an activated metal ligand compound comprises (a) a process for forming the first metal ligand compound in the first region on a substrate and forming the second metal ligand compound different from the first metal ligand compound in the second region on the substrate to form the arrays of the metal ligand compounds in the prescribed regions of the substrate at a space, and (b) a process for supplying one or more activating substances comprising ionizing agents or alkylating agents to the first region and the second region.

公开(公告)号：JP2002119847A

公开(公告)日：2002-04-23

申请号：JP2001233053

申请日：2001-08-01

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  LYNN VAN ERDEN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: PROBLEM TO BE SOLVED: To provide an apparatus and a method for controlling and monitoring the progress and characteristics of more than one reaction for monitoring and controlling a process and displaying/analyzing data by using a computer. SOLUTION: The apparatus includes more than one vessel 102 for holding the reaction mixture and a system for controlling the rotation speed of a stirring blade 108 and the temperature of each reaction mixture or a group of the mixtures so as to be effective in the synthesis, screening and characterization of combined chemical library and further can include equipment for controlling independently pressures of respective vessels and a system for injecting a liquid to the vessel under the pressure other than the atmospheric pressure. Respective reaction mixtures are monitored, and monitored results are fed back to a process controller, then the data for deciding various characteristics including the reaction rate, product yield, viscosity and molecular weight of the reaction product can be obtained.

公开(公告)号：JP2002143671A

公开(公告)日：2002-05-21

申请号：JP2001233054

申请日：2001-08-01

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  LYNN VAN ERDEN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: PROBLEM TO BE SOLVED: To provide a device and a method which is for controlling and monitoring the progress of plural reactions and the characteristics, particularly effective for the synthesis, screening and characterization of a combination chemical library and has important advantages as compared to the conventional experimental reactor. SOLUTION: A parallel reactor system 100 contains generally plural vessels 102 for holding reaction mixtures and a system for controlling the stirring speed and the temperature of the respective reaction mixtures or a group of the reaction mixtures of a reactor block 106 and can contain an equipment for controlling the pressure in each vessel individually and a system for injecting a liquid into the vessel under the pressure except the atmospheric pressure. The monitoring of each reaction mixture brings the feed back to a process controller and simultaneously gives data for deciding various characteristics of the reaction product, which includes the reaction rate, the product yield, the viscosity and the molecular weight.

公开(公告)号：JP2002241319A

公开(公告)日：2002-08-28

申请号：JP2001378679

申请日：2001-12-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG W HENRY ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BUSHY THOMAS ,  TURNER HOWARD ,  VAN BEEK JOHANNES A M ,  MURPHY VINCE ,  POWERS TIMOTHY

IPC: B01J23/22 ,  B01J19/00 ,  B01J31/22 ,  B01J37/00 ,  C07B61/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F19/00 ,  C08F4/70 ,  C08F10/00 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

Abstract: PROBLEM TO BE SOLVED: To provide a method for synthesizing a library of an organometallic material and screening the library in regard to catalytic activity. SOLUTION: This method for producing an array of a metal-ligand compound and screening comprises (a) synthesizing an array of spatially separated ligands, (b) preparing the array of metal-ligand compounds by feeding a suitable metal precursor to each of the elements of the array of ligands, (c) selectively activating the array of metal-ligand compounds with a suitable co-catalyst, (d) modifying the array of metal-ligand compounds with a third component, (e) screening the array of metal-ligand compounds in regard to useful characteristics by using a parallel or rapid serial screening method selected from a group consisting of an optical imaging, an optical spectroscopy, a mass spectroscopy, a chromatography, a sonic imaging, a sonic spectroscopy, an infrared imaging and an infrared spectroscopy.

公开(公告)号：DE60125873D1

公开(公告)日：2007-02-22

申请号：DE60125873

申请日：2001-07-13

Applicant: SYMYX TECHNOLOGIES INC

Inventor： VAN ERDEN LYNN ,  TURNER HOWARD ,  LOWE DAVID

IPC: B01J19/00 ,  B01J3/04 ,  B01L3/00 ,  G01N35/02

Abstract: An apparatus for use in parallel reaction of materials. The apparatus includes a base (32) having a plurality of reaction wells, each of the reaction wells (30) having a closed lower end (84) and open upper end for receiving reactant materials. A cover (34) is configured for sealing engagement with the base to form a housing enclosing the plurality of reaction wells and defining a common pressure chamber (26) in communication with the reaction wells. The apparatus further includes a flow restriction device (92) positioned adjacent to the open ends of the reaction wells to provide communication between the reaction wells and the pressure chamber while reducing cross-talk between the reactants and an inlet port (70) in communication with the pressure chamber for supplying pressurized fluid to the chamber to pressurize the reaction wells. The housing is configured to sustain a pressure substantially above atmospheric pressure.

公开(公告)号：CA2419700C

公开(公告)日：2006-10-17

申请号：CA2419700

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： NIELSEN RALPH B ,  HAJDUK DAMIAN A ,  DALES G CAMERON ,  TURNER HOWARD ,  MATSIEV LEONID ,  WANG PEI ,  VAN BEEK JOHANNES A M ,  VAN ERDEN LYNN ,  MCFARLAND ERIC ,  MANSKY PAUL

IPC: B01J19/18 ,  B01J19/00 ,  G01N31/00 ,  G01N33/00 ,  G05B19/042 ,  G05D23/19

Abstract: Devices and methods for controlling and monitoring the progress and properti es of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but als o offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixture s or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injectin g liquids into the vessels at a pressure different than ambient pressure. In situ monitorin g of individual reaction mixtures provides feedback for process controllers, and also provid es data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods a re disclosed for process monitoring and control, and for data display and analysis.

公开(公告)号：AT279973T

公开(公告)日：2004-11-15

申请号：AT01116442

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00 ,  B01F7/16

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：CA2306807C

公开(公告)日：2003-11-25

申请号：CA2306807

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MCFARLAND ERIC ,  WANG PEI ,  MANSKY PAUL ,  VAN BEEK JOHANNES A M ,  DALES G CAMERON ,  MATSIEV LEONID ,  VAN ERDEN LYNN ,  TURNER HOWARD

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: Devices and methods for controlling and monitoring the progress and properti es of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injectin g liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for proces s controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

公开(公告)号：ES2166209T3

公开(公告)日：2002-04-01

申请号：ES99203631

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG HENRY W ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BOUSSIE THOMAS ,  TURNER HOWARD ,  BEEK JOHANNES A M VAN

IPC: B01J23/22 ,  B01J19/00 ,  B01J31/16 ,  B01J31/22 ,  B01J37/00 ,  C07B61/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F17/00 ,  C07F19/00 ,  C08F4/00 ,  C08F4/60 ,  C08F4/70 ,  C08F10/00 ,  C08F110/02 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N1/10 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.