公开(公告)号：US3804593A

公开(公告)日：1974-04-16

申请号：US36969564

申请日：1964-05-25

Applicant: TECHNICON INSTR

Inventor： SMYTHE W ,  SHAMOS M

IPC: G01N35/08 ,  G01N31/00

CPC classification number: G01N35/08 ,  Y10T436/118339

Abstract: An automatic analysis apparatus includes an indexible table supporting a plurality of liquid sample containers, a stationary reagent liquid container, two off-take tubes, one tube insertable in a presented thereto sample container, the other tube insertable in the reagent container, means for concurrently inserting both tubes repeatedly into their respective containers to provide a flowing stream of segments of liquid sample interspersed by air segments, and a similar stream of segments of reagent. These streams are merged to form stream of liquid and air segments, which stream of liquid and air segments is passed through the sight passageway of a flow cell of a colorimeter. A recorder is coupled to the colorimeter, and may be rendered operational when the sight passageway of the flow cell is fully occupied by liquid.

Abstract translation: 一种自动分析装置，包括：支撑多个液体样品容器的可分度台，固定试液容器，两个取出管，可插入到样品容器中的一个管，可插入试剂容器中的另一个管，同时 将两个管重复插入其各自的容器中以提供由空气段散布的液体样品的段的流动流和类似的试剂段。 这些流合流以形成液体和空气段的流，该液流和空气流的流通过比色计的流动池的视线通道。 记录器耦合到色度计，并且当流动池的视线通道被液体完全占据时可以使其操作。

公开(公告)号：US3826615A

公开(公告)日：1974-07-30

申请号：US26148172

申请日：1972-06-09

Applicant: TECHNICON INSTR

Inventor： SMYTHE W ,  BELLINGER S ,  DIEBLER H ,  DANNEWITZ R

IPC: G01F13/00 ,  A61B5/00 ,  G01N1/00 ,  G01N35/08 ,  G01N1/18 ,  G01N33/16

CPC classification number: G01N35/08 ,  Y10T436/118339

Abstract: A FLUID SYSTEM FOR INCLUSION IN AN AUTOMATED FLUID SYSTEM FOR ANALYZING A SERIES OF LIQUID SAMPLES FLOWING SERIATIM, THE FIRST-MENTIONED SYSTEM SERVING TO DILUTE EACH SAMPLE FOR SUBSEQUENT DIVISION INTO A LARGE NUMBER OF PARTS. EACH DILUTEDPART IS INTENDED FOR FLOW TO ONE OF A LARGE NUMBER OF DIFFERENT SUBCOMBINATIONS OF THE TOTAL SYSTEM. IN EACH OF THE SUBCOMBINATIONS THE DILUTED SAMPLE PART MAY RECEIVE A SPECIAL TREATMENT, SUCH AS MIXING WITH APARTICULAR REAGENT OR REAGENTS UNDER CONTROLLED TEMPERATURE CONDITIONS FOR EXAMPLE, PRIOR TO ANALYSIS OF THAT SAMPLE PORTION AS BY PHOTOMETRY FOR EXAMPLE. EACH DILUTED SAMPLE PART MAY BE SUBJECTED TO A DIFFERENT TEST OR ANALYSIS THERE IS INVOLVED IN THE FIRST-MENTIONED SYSTEM THE SAME AND EQUAL DILUTION TREATMENT OF EACH SAMPLE AS THE SERIES. ALSO INVOLVED IN THE FIRST-MENTION SYSTEM IS THE EFFECTIVE INHIBITION OF CROSS CONTAMINATION OF SAMPLES FROM THE POINT OF INTRODUCTION OF THE SAMPLES INTO THE DILUTION SYSTEM TO THE POINT, AFTER DIVISION OF THE SAMPLES AS AFORESAID, WHERE THE SAMPLES FLOW INTO THE RESPECTIVE ONES OF THE AFORESAID ANALYSIS SUBCOMBINATIONS.

公开(公告)号：SE333647B

公开(公告)日：1971-03-22

申请号：SE1634865

申请日：1965-12-16

Applicant: TECHNICON INSTR

Inventor： SMYTHE W

IPC: G01N33/48 ,  G01N33/483 ,  G01N33/80 ,  G01N35/08 ,  G01N35/00

Abstract: 1,122,674. Blood sample analysis. TECH NICON INSTRUMENTS CORP. 24 Nov., 1965 [17 Dec., 1964], No. 49975/65. Heading B1X. A plurality of body fluid samples, for example blood samples, in sample containers 10 are analysed by a method comprising taking off aliquots of each sample through off take tubes 16, 18, dividing each aliquot into a series of quotient streams, a typical one of which flows in conduit 38 shown in Fig. 1, the quotients of successive samples being separated from each other by segments of inert fluid, treating each quotient stream for analysis by adding a respective reagent at 40, and depositing for examination at least a portion of each of the treated quotient streams through drip tubes 70 or 90 (Fig. 3 not shown) on to a moving web of sheet material 72, which may be absorbent or may have longitudinal channels (102) for deposits of treated quotient streams and shorter channels (104) to receive drippings of saline, the channels being subsequently covered by a sheet of cellulose acetate (106) (Fig. 4 not shown). If the samples are of centrifuged blood, off-take tube 16 is arranged to draw off red blood cells while tube 18 draws off serum, and the reagent added at 40 is one which will cause agglutination with blood of a given type.

公开(公告)号：SE301890B

公开(公告)日：1968-06-24

申请号：SE915564

申请日：1964-07-28

Applicant: TECHNICON INSTR

Inventor： WHITEHEAD E ,  SMYTHE W ,  ISREELI J

IPC: A61B5/117 ,  B01L3/14 ,  G01N35/02 ,  G01N21/00

Abstract: 1,055,235. Collecting blood. TECHNICON INSTRUMENTS CORPORATION. June 24. 1964 [July 30, 1963], No. 26180/64. Heading A5R. [Also in Divisions Bl, B8 and G1] A blood donation receptacle 21 and a sample cup 34 are connected by a strip 33 which bears in several places a donor identity number 42 and a code 43 representing the same number in a form such as punched holes, varying opacity or localy magnetised parts of an oxide film. Receptacle 21 and cup 34 are filled at the same donation and strip 33 is severed at line 44. Sample cups are loaded on a sample plate (52) (Fig. 4, not shown) with strips 33 projecting (Fig. 3, not shown), and plate (52) is indexed to bring successive cups under sample take off crook (62), whereby samples are drawn into automatic analyser (63) and analysed using anti-serum to determine groups. The result of each sample analysis is recorded on a moving chart (76) in terms of four traces produced by pens (69), (71), (72), (73). The descent of crook (62) actuates a mercury switch (91) which actuates a solenoid moving detector (81) to 'read' the code 43 on the adjacent strip 33, the code 43 being thus printed as a number (84) on chart (76). The analysis time is equal to the time taken for a cup 34 to move from crook (62) round to detector (81) so that the number (84) is printed adjacent the traces representing the corresponding sample on chart (76). Thus the receptacle 21 and a chart portion bearing the corresponding analysis bear the same identity number.

公开(公告)号：SE322360B

公开(公告)日：1970-04-06

申请号：SE679465

申请日：1965-05-24

Applicant: TECHNICON INSTR

Inventor： SMYTHE W ,  SHAMOS M

IPC: G01N35/08 ,  G01N31/00

Abstract: An automatic analysis apparatus includes an indexible table supporting a plurality of liquid sample containers, a stationary reagent liquid container, two off-take tubes, one tube insertable in a presented thereto sample container, the other tube insertable in the reagent container, means for concurrently inserting both tubes repeatedly into their respective containers to provide a flowing stream of segments of liquid sample interspersed by air segments, and a similar stream of segments of reagent. These streams are merged to form stream of liquid and air segments, which stream of liquid and air segments is passed through the sight passageway of a flow cell of a colorimeter. A recorder is coupled to the colorimeter, and may be rendered operational when the sight passageway of the flow cell is fully occupied by liquid.

公开(公告)号：SE321369B

公开(公告)日：1970-03-02

申请号：SE1045565

申请日：1965-08-10

Applicant: TECHNICON INSTR

Inventor： SMYTHE W

IPC: B01D19/00 ,  B01L5/04 ,  G01N33/487 ,  G01N35/08 ,  G01N33/00

Abstract: 1,097,264. Separating gases from liquids. TECHNICON INSTRUMENTS CORPORATION. July 21, 1965 [Aug. 12, 1964], No. 31048/65. Headings B1M and B1X. In the continuous testing of liquids having gas-releasable components by (a) adding a reagent to release the gas, (2) separating the gas from the liquid and, (3) treating the separated gas for analysis, stage (2) is carried out in a gas trap 42 in which an additional needle-like gas conduit 48 has its outlet 49 directed towards the liquid-gas inlet 40 so that additional gas issuing from outlet 49 bursts bubbles of gas which are growing in size on entry through inlet 40, the released gas rising through the trap and passing through outlet 44 for analysis. Liquid, free of gas, passes out through outlet 46 and pump tube 24 to a sump. Liquid containing gas to be tested, e.g. blood plasma or serum, is passed through tube and is fed with acid from pump tube 14 and with carbon dioxide free air from tube 16. In mixing coil 36 the carbon dioxide is liberated prior to passing into gas trap 42. The liberated gas leaving the trap through outlet 44 reacts with a colour reagent fed through tube 62, and the optical density of the stream of gas is measured in flow cell 72 by a monochromatic light source 74.

公开(公告)号：SE318425B

公开(公告)日：1969-12-08

申请号：SE968763

申请日：1963-09-04

Applicant: TECHNICON INSTR

Inventor： SMYTHE W

IPC: A61B5/155 ,  G01N33/483 ,  G01N35/08 ,  G01N33/16

公开(公告)号：SE318421B

公开(公告)日：1969-12-08

申请号：SE76163

申请日：1963-01-23

Applicant: TECHNICON INSTR

Inventor： SKEGGS L ,  ISREELI J ,  PELAVIN M ,  WHITEHEAD E ,  SMYTHE W

IPC: G01N35/08 ,  G01N31/00

Abstract: 1,007,224. Photo-electric analysis. TECHNICON INSTRUMENTS CORPORATION. Jan. 23, 1963 [Jan.23, 1962; Oct. 31, 1962], No. 2846/63. Heading G1A. [Also in Division B1] . In an arrangement for the quantitative analysis of a fluid sample having a plurality of known ingredients a like plurality of sample streams is formed each being treated for analysis in respect of a different ingredient and the quantitatively analysed separately during the flow of the treated streams. The invention, which has a general application, is described in connection with the analysis of body fluids e.g. blood or blood serum, in respect of such substances as albumin, total protein, chlorides, carbon dioxide, sodium, potassium, glucose and blood-urea-nitrogen. Known colorimetric and spectral-flame photo-electric analysing techniques are employed the analysis being effected sequentially in respect of the different substances and the results recorded. Fig. 1, shows one embodiment in which a take-off device 18 connected to aspirating tubes 20, 22 of a proportioning pump 24 (preferably of the kind disclosed in Specifications 817,070) withdraws a portion of fluid from one of a number sample cups 16 held in a rotary sampler device 14 (preferably of the kind disclosed in Specification 834,635) the arrangement being such that when a desired quantity of fluid has been withdrawn the take-off device 18 is inserted in another cup 16 and supplies the apparatus with a different sample separated from the first sample by an intervening air segment. Considering any one sample the operation of the apparatus is as follows. The portion of the sample withdrawn by pump tube 20 is combined in a fitting 28 with air (or inert gas), fed to tube 30, and with a liquid stream containing acidifed lithium nitrate, fed to tube 32, the air or inert gas serving to break up each sample into a number of liquid segments spaced by air segment which help maintain the tubes of the apparatus clean and prevent contamination of one sample by a preceding sample and the acidified lithium nitrate providing an internal standard for that portion of the sample which is to undergo spectral-flame analysis. This segmented liquid stream is fed via conduit 34 to one side, the sample is side, of a dialyzer 36 (preferably of the kind disclosed in Specifications 827,925 and 827,927) comprising plates 38a, 38b separated by a membrane 40 which operates to separate portion of the diffusible substances from the non-diffusible substances the former diffusing into a recipient stream comprising water and segmentising air supplied via respective pump tubes 44, 46 and fed over conduit 42 to the recipient side of the dialyzer from which it flows via conduit 48 whilst the non-diffusible substances flow from the sample side through a conduit 50. The (crystalloid) substances which diffuse into the recipient stream in conduit 48 comprise, blood-urea-nitrogen, glucose, sodium, potassium and chlorides (as well as a portion of the lithium nitrate) and to effect the required quantitative analysis the stream in conduit 48 is divided into separate streams by means of conduits 52,54,56,58 connected to respective tubes of pump 24. In the case of conduit 52 pump tube 146 operates to supply the stream to a fitting 144 which also receives via mixing coil 156 and a fitting 154 a segmentized colour-producing reagent stream formed by introducing colour-producing reagents suitable for the quantative analysis of the blood-urea-nitrogen content into pump tubes 148, 150 and a segmentizing fluid into pump tube 152 the combined streams being fed to a further mixing coil 158 and thence via a heating bath 162 to a debubbler 76f which removes the segmentizing fluid and supplies a consolidated liquid stream to the flow cell 80e of the colorimeter 82. In similar manner the stream in conduit 54 is segmentized and treated for analysis of the glucose content and supplied via heating bath 142 to flow cell 80d, that in conduit 58 being segmentized and treated for analysis in respect of the chloride content and fed to flow cell 80b whilst the streams in conduit 56, which, because of the presence of the lithium nitrate internal standard, does not require further treatment, is fed via debubbler 76d to the spectral flame photometer 60, the latter (preferably of the kind disclosed in App. 29969/60 Serial number 946689) having provision for effecting analysis in respect of both the sodium and potassium content. The flow through the sample side of the dialyzer via conduit 50 containing the colloidal substances as well as the remaining portions of the crystalloid substances is divided into two streams in respective conduits 64, 66, that in the former being segmentized and treated for analysis in respect of its total protein content and supplied to flow cell 80a whilst that in conduit 66 is treated for analysis of its carbon dioxide content (released by the acid content of the acidified lithium nitrate) by introducing a suitable anti-foam reagent via pump tube 104 and conduit 106 and supplying the resulting stream through a mixing coil 108 to a gas-liquid separator 110 (preferably as disclosed in Specification 909,415) the output of which is combined in pump fitting 116 with a suitable colour producing reagent introduced via pump tube 118 to provide a resultant stream for flow cell 80c, any remaining carbon-dioxide being removed by debubbler 76c. For the remaining analysis, that of the albumiun content, the sample is taken via conduit 26 (to avoid the adverse effects which the lithium nitrate introduced via pump tube 32 would have on the colorimetric treatment for albumiun) and after segmentizing and suitable colorimetric treatment via respective pump tubes 70, 68 is supplied via mixing coil 74 and debubbler 76 to flow cell 80. The flow cells (two 'spares' 80f, 80g being shown) are mounted on a carriage 178 (see also Fig. 2) which moves under the control of a reversing motor 188 driving a Geneva mechanism 192 and controlled by a timer 190 such that the cells are positioned in succession and for predetermined periods of time in the path of a light beam L co-operating with a measuring photo-electric device 174 (a photovoltive or photoconductive cell) and a similar reference device 172 (shown only in Fig. 1). When all the flow cells have reached the measuring position the carriage actuates a switch 202 which causes the motor 188 to reverse direction to drive the carriage in the opposite direction until the latter actuates switch 204 operation of which again reverses the direction of the motor which then drives the carriage in the first direction until the circuit to the motor is interrupted by switch 236 controlled by the Geneva mechanism. The apparatus is now in position to commence a second cycle when switch 216 is closed. Alternatively, the flow cells may be stationary and the light source and photo-electric devices arranged to move with respect thereto. In operation, the outputs of the photo-electric devices including devices 180,184, and 182, 186 comprising the reference and measurement photoelectric devices associated respectively with the spectral-flame analysis of the sodium and potassium contents are fed sequentially to the recorder control circuit 168 by means of switches 176 operated by shaft 308 driven in step with the movement of the carriage via rack-and-pinion 302, 304 (Fig. 2) the sequence being such that the various streams are examined in the order in which the colour reaction is completed this being aided by giving appropriate lengths to the flow paths between the pump and the various flow cells. In the case of Fig. 1, the flow cells are examined in the order shown except that the measurements of the sodium and potassium contents occur in the fifth and sixth positions thus producing a recording as shown by the trace 300 (Fig. 4). The recorder 166 and its control circuit 168 (which are of the type described in Specification 874,855) are described with reference to Fig. 3 (not shown) and generally comprises a null-type current ratio-balancing system to which the outputs of the measuring and reference photo-electric devices are supplied via banks of gauged switches driven in step with the switch banks 176 (Fig. 1). Additionally, means are provided to allow the use of linear ordinate scales in the case of recordings produced by colorimetric analysis, since in the latter case a logurithmic relationship exists between the concentration of the substance and the light transmission, and in the case of substances (e.g. glucose, carbon dioxide, sodium and potassium)for which the photo-electric response increases with increase in concentration of the substance a polarity traversing means for the output of the photo-electric devices is provided. Means are also described for calibrating the apparatus using substances of known concentrations the calibrations being printed on the chart (Fig. 4) either prior to use or concurrently therewith by the provision of printing plates produced from the calibration and secured to the recorder in position for printing the chart paper as it moves through the recorder. Each printing plate may be formed as a stretchable strip having equally spaced concentration numeral values so that the maximum and minimum values may be correctly positioned for each scale. The normal ranges for the concentration of each substance may be indicated by shaded areas 392. In a modification of the embodiment of Fig. 1 the colorimeter comprises stationary flow cells each provided with a light source and a measuring and reference photoelectric device (Fig. 5, not shown). In both embodiments the recorder maybe of the type which prints the actual numerical values of the concentration instead of employing a stylus to draw a curve. The colorimeter comprises the carriage number 178 (see Figs. 6 and 7) which is movable, as described in connection

公开(公告)号：SE303621B

公开(公告)日：1968-09-02

申请号：SE1211562

申请日：1962-11-12

Applicant: TECHNICON INSTR

Inventor： FERRARI A ,  SMYTHE W

IPC: B01D3/30 ,  G01N25/14

Abstract: 978,120. Distillation apparatus; separating fractions of a liquid mixture for chemical analysis. TECHNICON INSTRUMENTS CORPORATION. Nov. 5, 1962 [Nov. 13, 1961], No. 41672/62. Heading B1B. Liquid to be distilled is fed through tube 90 into the end of a helical passage 14 formed along the inner surface of a horizontal cylindrical vessel 12 which is rotated about its longitudinal axis on rollers 24. The lower portion of the vessel is heated by electrical heater 20. Discrete elements of the liquid pass along the vessel in the lowest sections of the helical passage. The vapours evolved from the heated liquid are drawn into tube 56 through holes 60, and then flow through line 65 into condenser 64, by the action of a vacuum pump connected to the outlet 79 of the condenser. The condensate collects in receptacle 80. The residual undistilled liquid reaching the left-hand end of vessel 12 discharges into outlet cap 44, and leaves the apparatus through outlet 52. For the separation of a liquid mixture, a number of separate vapour tubes 62, Fig. 3, are located within the tube 56, each tube 62 being connected to one of the holes 60 in tube 56 and leading to a separate condenser. The components of the liquid mixture vaporize in sequence in vessel 12, and the vapour fractions are withdrawn via the separate tubes 62. The apparatus may be used for the separation of samples for chemical analysis, e.g. in the determination of the alcohol content of beer, or the phenol content of plant effluent. Specifications 774,711, 783,649 and 834,635 are referred to.

公开(公告)号：SE316932B

公开(公告)日：1969-11-03

申请号：SE228566

申请日：1966-02-22

Applicant: TECHNICON INSTR

Inventor： SMYTHE W ,  SHAMOS M

IPC: G01N11/08 ,  G01N15/02 ,  G01N33/487 ,  G01N33/49