公开(公告)号：WO8900697A3

公开(公告)日：1989-02-23

申请号：PCT/US8802153

申请日：1988-06-21

Applicant: TECHNICON INSTR

Inventor： CASSADAY MICHAEL M ,  CHRISTIANO VITO F ,  VASUDEVA BACHALLI

IPC: B01D17/02 ,  G01N35/08 ,  G01N35/00 ,  B01L11/00

CPC classification number: G01N35/08 ,  B01D17/0214 ,  B01D17/04 ,  B01D17/045 ,  Y10T436/118339

Abstract: Apparatus and method are provided for the substantial separation on a continuous flow basis of immisicible liquids flowing as a common stream, with one of said liquids substantially encapsulating another of said liquids, in a flow conduit. The conduit comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of another of the liquids; and the liquid separator apparatus are disposed in the conduit and operate to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream as that stream flows into contact with the separator apparatus in the conduit. Apparatus and method for the introduction of a liquid on a continuous flow basis into a flowing stream of another liquid which is immisicible therewith and is flowing in a flow conduit are also provided. The conduit again comprises an inner surface which is selectively "wettable" by one of the liquids to the substantial exclusion of the other of the liquids; and the liquid introduction apparatus are disposed in the conduit and operate to form a common stream of the liquids for continued flow in the conduit, with one of the liquids being substantially encapsulated by another of the liquids, as the liquids are merged at the liquid introduction apparatus in the conduit. A liquid processing system including the conduit is provided wherein the liquid introduction apparatus are utilized to form the common liquids stream with one of the liquids being substantially encapsulated within the other of the liquids at a first location in the system; and the liquid separator apparatus are utilized to substantially separate the liquids, or at least a portion of one of the liquids, from the common liquids stream at a second location in the system which is downstream of the first location. As representatively configured in the herein disclosed preferred embodiments, the apparatus and method are applied to automated continuous flow sample liquid analysis systems wherein one of the liquids is an aqueous sample liquid, and the other of the liquids is an isolation liquid which selectively "wets" the hydrophobic inner surface of the flow conduit to the substantial exclusion of the aqueous sample liquids, and which functions to substantially encapsulate the aqueous sample liquids in the common liquids stream; and, for such application, the apparatus and method provide for significant increase in the accuracy of the sample liquid analysis results.

公开(公告)号：US3905418A

公开(公告)日：1975-09-16

申请号：US41902773

申请日：1973-11-26

Applicant: TECHNICON INSTR

Inventor： WATTS LEONARD

IPC: B22D11/047 ,  B22D11/02

CPC classification number: B22D11/047

Abstract: Apparatus for continuous casting of metals including a cooled axial mold wall defining at least part of a mold cavity and a wall structure extending transversely of the axial wall and located therein, provided with a solid cooled sealing element of resilient graphitic material extending therearound and internally abutting the axial wall which is moved on its axis relatively to the transverse wall. On the face thereof which contacts molten metal and covering a portion of the sealing element in overlapping relation, such transverse wall has a refractory element having an outer surface portion thereof adjacent the axial mold wall disposed at an angle to the last-mentioned wall. There is also provided a nozzle structure having improved thermal characteristics for delivering molten metal to a mold cavity for continuous casting.

Abstract translation: 用于连续铸造金属的装置，包括限定模腔的至少一部分的冷却的轴向模具壁和横向于轴向壁延伸并位于其中的壁结构，其具有在其周围延伸并且内部邻接的弹性石墨材料的固体冷却密封元件 相对于横向壁在其轴线上移动的轴向壁。 在与熔融金属接触并且以重叠关系覆盖密封元件的一部分的表面上，这种横向壁具有耐火元件，该耐火元件的外表面部分邻近与最后提到的壁成角度设置的轴向模壁。 还提供了具有改进的热特性的喷嘴结构，用于将熔融金属输送到用于连续铸造的模腔中。

公开(公告)号：US3876374A

公开(公告)日：1975-04-08

申请号：US45389674

申请日：1974-03-22

Applicant: TECHNICON INSTR

Inventor： BURNS DONALD A

IPC: G01N21/27 ,  G01N21/75 ,  G01N33/48 ,  G01N35/08 ,  G01N33/16 ,  G01N1/14 ,  G01N21/26

CPC classification number: G01N35/08 ,  Y10T436/118339

Abstract: Method and apparatus for reaction-rate analysis wherein a fluid sample, which has been treated to undergo a reaction, is flowed into a conduit and then flowed out of the conduit in the reverse direction so that the first sample portion which enters the conduit is the last sample portion to leave the conduit. The outflow of the conduit is to an analysis station wherein a constituent of interest of the sample is quantitatively analyzed.

公开(公告)号：US3830223A

公开(公告)日：1974-08-20

申请号：US29018372

申请日：1972-09-18

Applicant: TECHNICON INSTR

Inventor： BERETSKY I ,  LICHTENSTEIN B

IPC: A61B8/00 ,  A61B8/08 ,  A61B5/02 ,  A61B10/00

CPC classification number: A61B8/0858

Abstract: New and improved methodology and apparatus for non-invasive biophysical diagnosis are disclosed and comprise the ensonification of body parts with multi-frequency energy pulses in predetermined timed sequence, the detection of the resultant echo pulses, the processing of the latter to provide signals indicative of the impedance of the body part, the referencing of said signals to the biophysical cycle of the body part, and the real time display of said signals in the form of an impedance profile of said body part.

Abstract translation: 公开了用于非侵入性生物物理诊断的新的和改进的方法和装置，并且包括以预定的定时序列与多频能量脉冲的身体部分的融合，所产生的回波脉冲的检测，后者的处理以提供指示 身体部位的阻抗，所述信号对身体部位的生物物理循环的参照，以及所述身体部位的阻抗曲线形式的所述信号的实时显示。

公开(公告)号：US3826615A

公开(公告)日：1974-07-30

申请号：US26148172

申请日：1972-06-09

Applicant: TECHNICON INSTR

Inventor： SMYTHE W ,  BELLINGER S ,  DIEBLER H ,  DANNEWITZ R

IPC: G01F13/00 ,  A61B5/00 ,  G01N1/00 ,  G01N35/08 ,  G01N1/18 ,  G01N33/16

CPC classification number: G01N35/08 ,  Y10T436/118339

Abstract: A FLUID SYSTEM FOR INCLUSION IN AN AUTOMATED FLUID SYSTEM FOR ANALYZING A SERIES OF LIQUID SAMPLES FLOWING SERIATIM, THE FIRST-MENTIONED SYSTEM SERVING TO DILUTE EACH SAMPLE FOR SUBSEQUENT DIVISION INTO A LARGE NUMBER OF PARTS. EACH DILUTEDPART IS INTENDED FOR FLOW TO ONE OF A LARGE NUMBER OF DIFFERENT SUBCOMBINATIONS OF THE TOTAL SYSTEM. IN EACH OF THE SUBCOMBINATIONS THE DILUTED SAMPLE PART MAY RECEIVE A SPECIAL TREATMENT, SUCH AS MIXING WITH APARTICULAR REAGENT OR REAGENTS UNDER CONTROLLED TEMPERATURE CONDITIONS FOR EXAMPLE, PRIOR TO ANALYSIS OF THAT SAMPLE PORTION AS BY PHOTOMETRY FOR EXAMPLE. EACH DILUTED SAMPLE PART MAY BE SUBJECTED TO A DIFFERENT TEST OR ANALYSIS THERE IS INVOLVED IN THE FIRST-MENTIONED SYSTEM THE SAME AND EQUAL DILUTION TREATMENT OF EACH SAMPLE AS THE SERIES. ALSO INVOLVED IN THE FIRST-MENTION SYSTEM IS THE EFFECTIVE INHIBITION OF CROSS CONTAMINATION OF SAMPLES FROM THE POINT OF INTRODUCTION OF THE SAMPLES INTO THE DILUTION SYSTEM TO THE POINT, AFTER DIVISION OF THE SAMPLES AS AFORESAID, WHERE THE SAMPLES FLOW INTO THE RESPECTIVE ONES OF THE AFORESAID ANALYSIS SUBCOMBINATIONS.

公开(公告)号：US3819488A

公开(公告)日：1974-06-25

申请号：US16441571

申请日：1971-07-20

Applicant: TECHNICON INSTR

Inventor： RUSH R ,  LEON L ,  DE LEA A

IPC: C12Q1/32 ,  C12Q1/52 ,  G01N31/14

CPC classification number: C12Q1/52 ,  C12Q1/32

Abstract: Stable, lyophilized diagnostic compositions are disclosed effective in determining glutamic oxalic transaminase (GOT) and glutamic pyruvic transaminase (GPT) comprising malate dehydrogenase (for GOT) or lactate dehydrogenase (for GPT), a pyridine nucleotide and a buffer having a sodium content of less than about 600 meq./1. capable of regulating the pH of the composition in reconstituted form. Also disclosed are the aqueous reconstituted products, the method of determining the activity of GOT and GPT in a sample using the subject compositions and the process for making the disclosed diagnostic compositions.

Abstract translation: 公开了稳定的冻干诊断组合物，用于测定含有苹果酸脱氢酶（GOT）或乳酸脱氢酶（GPT）的谷氨酸转氨酶（GOT）和谷氨酸丙酮酸转氨酶（GPT），吡啶核苷酸和钠含量少的缓冲液 比约600meq./1。 能够以重构形式调节组合物的pH。 还公开了水性重构产物，使用主题组合物和制备所公开的诊断组合物的方法测定样品中GOT和GPT的活性的方法。

公开(公告)号：US3795149A

公开(公告)日：1974-03-05

申请号：US3795149D

申请日：1971-10-15

Applicant: TECHNICON INSTR

Inventor： NEGERSMITH K ,  GILLETTE W ,  MC CANDLESS W

IPC: G01N1/00 ,  G01N35/10 ,  G01R1/12

CPC classification number: G01N35/1004 ,  G01N35/1095

Abstract: Liquid from a liquid sample container is flowed in automated analysis apparatus into a filter-equipped inlet end of a probe while the latter is immersed in the liquid, for transport of the sample to automated analysis. The probe is subsequently removed from the container and immersed in the liquid of a wash receptacle. Prior to immersion in another liquid sample, a fluid, other than sample, is flushed through the aforementioned filter in a reverse direction to cleanse it of particulate matter, the flushing being in timed relation to the movements of the probe.

Abstract translation: 来自液体样品容器的液体在自动分析装置中流入探针的过滤器入口端，而后者浸入液体中，用于将样品运送到自动分析。 随后将探针从容器中取出并浸入洗涤容器的液体中。 在浸入另一种液体样品之前，除了样品之外的流体沿相反方向冲洗通过上述过滤器，以清洁颗粒物质，冲洗与探针的运动定时关联。

公开(公告)号：US3740145A

公开(公告)日：1973-06-19

申请号：US3740145D

申请日：1970-09-14

Applicant: TECHNICON INSTR

Inventor： MITCHELL D

IPC: G01N21/31 ,  G01N21/72 ,  G01J3/00

CPC classification number: G01N21/72 ,  G01N21/3103

Abstract: New and improved method and apparatus for the analysis of samples by atomic spectroscopy are provided and comprise sample atom production means taking the form of body means having a generally central sample chamber extending generally longitudinally therethrough, and heating means for heating said chamber and adjacent areas to convert said sample to atoms. Sample stream generation means in the nature of drop generator means are operably associated with said body means at the lower extremity thereof and are effective to generate a stream of sample drops of substantially uniform size for upward passage through said body chamber to result in a formation of a concentrated atom cloud or sample volume of the sample atoms of interest above said body means. Means are provided to modulate the formation of said sample volume by said sample drop stream to provide for more accurate read-out of the sample atom concentration of interest. Means are also provided to enable the simultaneous multielement analysis of a sample by atom spectroscopy and comprise a plurality of drop generator means which are operable to generate a plurality of sample drop streams for passage through said body chamber to form said sample volume, and means are provided to periodically and alternately deflect said sample drop streams from passage into said sample volume to substantially eliminate signal interference. As disclosed, the new and improved method and apparatus of the invention are particularly adaptable for use in automatically operable sample supply, treatment and analysis means which are operable to automatically analyze a series stream of a large plurality of different samples on a continuous flow basis.

Abstract translation: 提供了用于通过原子光谱法分析样品的新的和改进的方法和装置，并且包括采样体形式的样品原子产生装置，其具有通常纵向延伸穿过的通常中心的样品室的主体装置，以及用于将所述室和相邻区域加热的加热装置 将所述样品转化为原子。 液滴发生器装置本质上的样品流产生装置在其下端可操作地与所述主体装置相关联，并且有效地产生基本均匀尺寸的样品流，以向上通过所述体腔，以形成 在所述身体装置上方的感兴趣的样品原子的浓缩原子云或样品体积。 提供装置以通过所述样品液滴流调节所述样品体积的形成，以提供更准确地读出所关注的样品原子浓度。

公开(公告)号：US3699004A

公开(公告)日：1972-10-17

申请号：US3699004D

申请日：1970-08-31

Applicant: TECHNICON INSTR

Inventor： SKEGGS LEONARD T

IPC: G01N33/483 ,  G01N35/08 ,  G01N31/14

CPC classification number: G01N35/08 ,  Y10T436/118339

Abstract: NEW AND IMPROVED METHOD AND APPARATUS FOR THE FULLY AUTOMATIC, HIGHLY ACCURATE QUANTITATIVE ANALYSIS OF A SERIES OF SAMPLES WITH REGARD TO A CONSTITUENT THEREOF ON A CONTINUOUS FLOW BASIS THROUGH RATE REACTION DETERMINATION ARE PROVIDED AND ARE OPERABLE THROUGH THE CONTINUOUS MIXING OF SAID SAMPLES AND A SUITABLE REACTANT IN CONSTANT PROPORTION, AND THE FLOW OF THE RESULTANT SAMPLE-REACTANT MIXTURES BY PUMPING ON A CONTINUOUS BASIS THROUGH REACTION PROMOTING MEANS TO PROMOTE THE SAMPLE CONSTITUENT-REACTANT RATE REACTION IN SUCH MANNER THAT DIFFERENT PORTIONS OF EACH OF THE SAMPLE-REACTANT MIXTURES ARE REACTED FOR DIFFERENT TIMES TO EFFECT A DIFFERENTIAL IN A CHARACTERISTIC OF SAID MIXTURES AS DEVELOPED AS A RESULT OF SAID REACTION. FOLLOWING THIS, THE THUSLY REACTED SAMPLE-REACTANT MIXTURE PORTIONS ARE FLOWED THROUGH DETECTOR MEANS FOR DETECTION OF SAID CHARACTERISTIC DIFFERENTIAL AND RESULTANT PROVISION OF AND OUTPUT SIGNAL WHICH IS INDICATIVE OF THE SAMPLE CONSTITUENT QUANTITY OF INTEREST. SUBSTANTIALLY HYPERBOLIC VARIATION IN THE FLOW RATE OF EACH OF SAID SAMPLE-REACTANT MIXTURES THROUGH SAID REACTION PROMOTING MEANS IS UTILIZED TO PROVIDE FOR THE DIFFERENT SAMPLE-REACTANT MIXTURE PORTION REACTION TIMES. AS SPECIFICALLY DISCLOSED HEREIN, THE METHOD AND APPARATUS OF THE INVENTION ARE PARTICULARLY ADAPTABLE TO THE ANALYSIS OF A SERIES OF BLOOD SAMPLES WITH REGARD TO AN ENZYME CONSTITUENT THEREOF.

公开(公告)号：US3681577A

公开(公告)日：1972-08-01

申请号：US3681577D

申请日：1970-10-30

Applicant: TECHNICON INSTR

Inventor： GASIUNAS DONATAS V

IPC: A61B5/145 ,  G01D18/00 ,  G01N21/27 ,  G01N21/31 ,  H03M1/00 ,  G06F15/46

CPC classification number: H03M1/00 ,  G01D18/002 ,  G01N21/274 ,  G01N21/3103 ,  H03M1/1009

Abstract: New and improved apparatus are provided for the automatic calibration of automatic, multiple channel sample analysis means and comprise level set means to automatically control the level of the analysis means analog output signals and maintain the latter within the same general operating range, zero set means to automatically determine the background signal level for each analysis channel and subtract the same from the analysis channel output signal, attendant the conversion thereof to digital form, and calibration means to vary the scale factor involved in said signal conversion in accordance with the operating characteristics of each of said analysis channels.