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    ARRAY ATOMIC FORCE MICROSCOPY FOR ENABLING SIMULTANEOUS MULTI-POINT AND MULTI-MODAL NANOSCALE ANALYSES AND STIMULATIONS
    2.
    发明申请
    ARRAY ATOMIC FORCE MICROSCOPY FOR ENABLING SIMULTANEOUS MULTI-POINT AND MULTI-MODAL NANOSCALE ANALYSES AND STIMULATIONS 审中-公开

    公开(公告)号：WO2020076877A1

    公开(公告)日：2020-04-16

    申请号：PCT/US2019/055273

    申请日：2019-10-08

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： LAL, Ratneshwar ,  YANG, Qingqing ,  MA, Qian ,  LIU, Zhaowei

    IPC: G01Q20/02 ,  G01Q60/38

    Abstract: Disclosed is an atomic force microscopy system includes a laser source configured to generate an optical probe beam containing light of different spectral light components at different optical wavelengths, a dispersive optical device positioned to receive the optical probe beam and configured to disperse the optical probe beam into different dispersed light beams that are at different optical wavelengths and are spatially separated from one another, a cantilever array including a plurality of cantilevers structured to detect a sample and configured to deflect the different dispersed light beams by moving in position based on an interaction with the sample to produce multiple deflected output beams at different output optical wavelengths from the cantilevers, and a plurality of photodetectors to receive the multiple deflected output beams of different wavelengths from the cantilevers, respectively.

    IMPROVED NANOTUBE-BASED NANOPROBE STRUCTURE AND METHOD FOR MAKING THE SAME
    3.
    发明申请
    IMPROVED NANOTUBE-BASED NANOPROBE STRUCTURE AND METHOD FOR MAKING THE SAME 审中-公开
    改进的基于纳米管的纳米棒结构及其制造方法

    公开(公告)号：WO2006041691A2

    公开(公告)日：2006-04-20

    申请号：PCT/US2005/034835

    申请日：2005-09-29

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  JIN, Sungho ,  LAL, Ratneshwar

    Inventor： JIN, Sungho ,  LAL, Ratneshwar

    IPC: B32B27/04

    CPC classification number: G01Q70/12 ,  G01Q60/38 ,  Y10T428/24

    Abstract: An atomic force microscopy (AFM) nanoprobe comprising a nanocone base and a nanoprobe tip wherein the length to base diameter aspect ratio is at least 3 or more. The AFM nanoprobe tip structure comprises an orientation-controlled (vertical or inclined), high-aspect-ratio nanocone structure without catalyst particles, with a tip radius of curvature of at most 20 nm.

    Abstract translation: 原子力显微镜（AFM）纳米探针包括纳米锥基体和纳米针尖，其中长度与基体直径的纵横比为至少3或更大。 AFM纳米探针尖端结构包括无催化剂颗粒的取向控制（垂直或倾斜），高纵横比纳米锥体结构，尖端曲率半径最大为20nm。

    NANOSTRUCTURED CARRIERS FOR GUIDED AND TARGETED ON-DEMAND SUBSTANCE DELIVERY
    7.
    发明申请
    NANOSTRUCTURED CARRIERS FOR GUIDED AND TARGETED ON-DEMAND SUBSTANCE DELIVERY 审中-公开
    用于指导和有针对性的物料运输的纳米技术运输

    公开(公告)号：WO2015192149A2

    公开(公告)日：2015-12-17

    申请号：PCT/US2015/035898

    申请日：2015-06-15

    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    Inventor： LAL, Ratneshwar ,  LANDON, Preston, B. ,  MO, Alexander

    IPC: A61K9/51 ,  A61K48/00

    CPC classification number: A61K41/00 ,  A61K9/0009 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5192 ,  A61K38/05 ,  A61K41/0028 ,  A61K47/6923 ,  A61K47/6925 ,  A61K47/6941

    Abstract: Methods, systems, and devices are disclosed for fabricating and implementing nanoscale and microscale structured carriers to provide guided, targeted, and on-demand delivery of molecules and biochemical substances for a variety of applications including diagnosis and/or treatment (theranostics) of diseases in humans and animals. In some aspects, a nanostructure carrier can be synthesized in the form of a nanobowl, which may include an actuatable capping particle that can be opened (and in some implementations, closed) on demand. In some aspects, a nanostructure carrier can be synthesized in the form of a hollow porous nanoparticle with a functionalized interior and/or exterior to attach payload substances and substances for magnetically guided delivery and controlled release of substance payloads.

    Abstract translation: 公开了用于制造和实施纳米尺度和微观结构化载体的方法，系统和装置，以针对各种应用提供分子和生化物质的指导，靶向和按需递送，包括疾病的诊断和/或治疗（主治） 人类和动物。 在一些方面，纳米结构载体可以以纳米颗粒的形式合成，其可以包括可根据需要打开（并且在一些实施方式中，封闭的）的可致动的封盖颗粒。 在一些方面，纳米结构载体可以以具有官能化内部和/或外部的中空多孔纳米颗粒的形式合成，以附接有效载荷物质和物质用于磁性引导递送和物质有效载荷的受控释放。

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