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    1.
    发明专利
    未知

    公开(公告)号：DE69232259T2

    公开(公告)日：2002-06-13

    申请号：DE69232259

    申请日：1992-04-17

    Applicant: TORAY INDUSTRIES

    Inventor： SAKURAI SHINGOU ,  NARUTO MASANOBU ,  KIHARA MAKOTO ,  HANADA KEIZO ,  SANO EMIKO ,  ICHIKURA SHIGERU ,  UTSUMI JUN ,  HOSOI KAZUO

    IPC: A61K38/00 ,  C07K14/54 ,  C07K1/22

    Abstract: A composition containing human interleukin 6 having a saccharide chain, a process for producing human interleukin 6 by culturing cells in a medium containing ascorbic acid or its derivative, and a process for purifying a crude human interleukin 6 solution by chromatography using heparin carrier. The invention makes it possible to produce a high-quality composition containing human interleukin 6 having a saccharide chain to thereby apply the same in the medicinal use and to establish a process for mass producing human interleukin 6.

    THERAPEUTIC AGENT FOR TREATING WOUNDS
    2.
    发明专利
    THERAPEUTIC AGENT FOR TREATING WOUNDS 未知

    公开(公告)号：CA2149323A1

    公开(公告)日：1995-03-23

    申请号：CA2149323

    申请日：1994-09-13

    Applicant: TORAY INDUSTRIES

    Inventor： MATSUSHIMA KOJI ,  NARUTO MASANOBU

    IPC: A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  A61P17/00 ,  C07K14/52 ,  A61K38/19

    Abstract: 19 A therapeutic agent for treating wounds having properties and actions different from those of growth factors and proteins inducing growth factors, which have strong therapeutic effect is disclosed. The therapeutic agent for treating wounds according to the present invention comprises monocyte chemotactic and activating factor or a variation thereof having a monocyteattracting property or a derivative of said monocyte chemotactic and activating factor or said variation thereof.

    PROCESS FOR PREPARING ANGELIC ACID OR ITS ESTER
    6.
    发明专利
    PROCESS FOR PREPARING ANGELIC ACID OR ITS ESTER 未知

    公开(公告)号：DE3280004D1

    公开(公告)日：1989-12-07

    申请号：DE3280004

    申请日：1982-06-28

    Applicant: TORAY INDUSTRIES

    Inventor： NARUTO MASANOBU ,  KONDO HISAO ,  HATA GO

    IPC: C07C51/353 ,  C07C69/527 ,  C07D307/42 ,  C11B9/00 ,  C07C57/03 ,  C07C69/533 ,  C07C67/333 ,  A61K7/46

    Abstract: PCT No. PCT/JP82/00248 Sec. 371 Date Feb. 24, 1984 Sec. 102(e) Date Feb. 24, 1984 PCT Filed Jun. 28, 1982 PCT Pub. No. WO84/00161 PCT Pub. Date Jan. 19, 1984.Angelic acid or esters thereof which are useful as perfume materials are prepared by isomerizing tiglic acid or an ester thereof with an organic sulfinic acid as the catalyst, and novel esters of angelic acid represented by the formula wherein R represents 3-hexenyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 3-methyl-2-pentenyl, 3-methyl-4-pentenyl, CH3(CH2)l- (in which l is an integer from 5 to 9), cyclopentyl, cyclohexyl, 2-methylpentyl, alpha -methylbenzyl, neryl or furfuryl are provided as part of said esters of angelic acid.

    7.
    发明专利
    未知

    公开(公告)号：ES2164050T3

    公开(公告)日：2002-02-16

    申请号：ES92908258

    申请日：1992-04-17

    Applicant: TORAY INDUSTRIES

    Inventor： SAKURAI SHINGOU ,  NARUTO MASANOBU ,  KIHARA MAKOTO ,  HANADA KEIZO ,  SANO EMIKO ,  ICHIKURA SHIGERU

    IPC: A61K38/00 ,  C07K14/54 ,  C07K1/22

    Abstract: A composition containing human interleukin 6 having a saccharide chain, a process for producing human interleukin 6 by culturing cells in a medium containing ascorbic acid or its derivative, and a process for purifying a crude human interleukin 6 solution by chromatography using heparin carrier. The invention makes it possible to produce a high-quality composition containing human interleukin 6 having a saccharide chain to thereby apply the same in the medicinal use and to establish a process for mass producing human interleukin 6.

    AGENT PROMOTING CONCEPTION
    8.
    发明专利
    AGENT PROMOTING CONCEPTION 未知

    公开(公告)号：CA2203768A1

    公开(公告)日：1997-03-06

    申请号：CA2203768

    申请日：1996-08-28

    Applicant: TORAY INDUSTRIES

    Inventor： KANEKO TATSUYA ,  KANAYAMA NAOHIRO ,  TERAO TOSHIHIKO ,  NARUTO MASANOBU

    IPC: A61K38/16 ,  A61K38/19 ,  A61K38/20

    Abstract: A fertility agent comprising as the active ingredient a leukocyte migration factor (interleukin 8, monocyte chemotactic factor, etc.) or a leukocyte migration factor inducer (interleukin 1, tumor necrotizing factor, interferon .gamma., platelet-activating factor, endotoxin, etc.). The effects of this drug are based on the fact that a leukocyte migration factor or an inducer thereof is efficacious as a single substance in the promotion of both of the growth of an ovum and the implantation of fertilized ovum. It is broadly usable in various industrial fields as a remedy for human and animal infertility and for veterinary and zootechnical purposes of, for example, promoting the production of industrial animals and conserving rare animal species.

    AGENT FOR PREVENTING OR TREATING HEMORRHAGE TENDENCY
    9.
    发明专利
    AGENT FOR PREVENTING OR TREATING HEMORRHAGE TENDENCY 未知

    公开(公告)号：CA2098008A1

    公开(公告)日：1993-04-10

    申请号：CA2098008

    申请日：1992-10-08

    Applicant: TORAY INDUSTRIES

    Inventor： OKAMOTO TASUKU ,  OKANO KIYOSHI ,  SATO YUICHIRO ,  IDA NOBUTAKA ,  NARUTO MASANOBU

    IPC: A61K38/00 ,  A61K38/20 ,  C07K14/54

    Abstract: An agent for preventing or treating hemorrhage tendency comprising IL-6 as an active ingredient is presented. The in vivo administration of IL-6 enhances both platelet function and vascular endothelial cell function, to improve predispositions to bleeding disorder, thereby promoting hemostatic ability. That is, IL-6 has activity to efficiently treat hemorrhage tendency in vivo, and since it is an inherently natural bioactive substance, it is useful as an excellent phermaceutical composition for treating or preventing hemorrhage tendency. Thus, IL-6 is useful for treating the hemorrhage tendency attributable to the bone marrow supression occurring after the chemotherapy of cancer or after the radiotherapy of cancer, the hemorrhage tendency occurring after bone marrow transplantation, the hemorrhage tendency of aplastic anemia, and the hemorrhage tendency in idiopathic thrombocytopenic purpura.

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