公开(公告)号：CA2070497A1

公开(公告)日：1992-12-11

申请号：CA2070497

申请日：1992-06-04

Applicant: TORAY INDUSTRIES

Inventor： HATA GO ,  KANEKO TATSUYA ,  KAWAI HIDEKI ,  MUTOH MASATO ,  HASHIMOTO HIDEYUKI

IPC: A61K31/555 ,  A61P35/00 ,  C07F15/00

Abstract: A platinum(II) complex is represented by the general formula (A), in which R1 represents a hydrocarbon radical having 1 to 10 carbon atoms, R2 and R3 each represent a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, or R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X and Y each represent an ammonia molecule or a monodentate and Y each represent an ammonia molecule or a monodentate amine having 1 to 7 carbon atoms or X and Y, together, amine having 1 to 7 carbon atoms or X and Y, together, may form a bidentate diamine having 2 to 10 carbon atoms. The compounds are useful for treating tumors.

公开(公告)号：GR3022607T3

公开(公告)日：1997-05-31

申请号：GR970400293

申请日：1997-02-19

Applicant: TORAY INDUSTRIES

Inventor： HATA GO ,  KANEKO TATSUYA ,  KAWAI HIDEKI ,  MUTOH MASATO ,  HASHIMOTO HIDEYUKI

IPC: A61K31/555 ,  A61P35/00 ,  C07F15/00 ,  C07D307/46

Abstract: A platinum(II) complex is represented by the general formula (A), in which R1 represents a hydrocarbon radical having 1 to 10 carbon atoms, R2 and R3 each represent a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, or R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X and Y each represent an ammonia molecule or a monodentate and Y each represent an ammonia molecule or a monodentate amine having 1 to 7 carbon atoms or X and Y, together, amine having 1 to 7 carbon atoms or X and Y, together, may form a bidentate diamine having 2 to 10 carbon atoms. The compounds are useful for treating tumors.

公开(公告)号：AT147747T

公开(公告)日：1997-02-15

申请号：AT92305328

申请日：1992-06-10

Applicant: TORAY INDUSTRIES

Inventor： HATA GO ,  KANEKO TATSUYA ,  KAWAI HIDEKI ,  MUTOH MASATO ,  HASHIMOTO HIDEYUKI

IPC: A61K31/555 ,  A61P35/00 ,  C07F15/00 ,  C07D307/46

Abstract: A platinum(II) complex is represented by the general formula (A), in which R1 represents a hydrocarbon radical having 1 to 10 carbon atoms, R2 and R3 each represent a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, or R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X and Y each represent an ammonia molecule or a monodentate and Y each represent an ammonia molecule or a monodentate amine having 1 to 7 carbon atoms or X and Y, together, amine having 1 to 7 carbon atoms or X and Y, together, may form a bidentate diamine having 2 to 10 carbon atoms. The compounds are useful for treating tumors.

公开(公告)号：AU6836896A

公开(公告)日：1997-03-19

申请号：AU6836896

申请日：1996-08-28

Applicant: TORAY INDUSTRIES

Inventor： TERAO TOSHIHIKO ,  KANAYAMA NAOHIRO ,  NARUTO MASANOBU ,  KANEKO TATSUYA

IPC: A61K38/16 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21

Abstract: A fertility agent comprising as the active ingredient a leukocyte migration for (interleukin 8, monocyte chemotactic factor, etc.) or a leukocyte migration factor inducer (interleukin 1, tumor necrotizing factor, interferon gamma , platelet-activating factor, endotoxin, etc.). The effects of this drug are based on the fact that a leukocyte migration factor or an inducer thereof is efficacious as a single substance in the promotion of both of the growth of an ovum and the implantation of fertilized ovum. It is broadly usable in various industrial fields as a remedy for human and animal infertility and for veterinary and zootechnical purposes of, for example, promoting the production of industrial animals and conserving rare animal species.

公开(公告)号：ES2096721T3

公开(公告)日：1997-03-16

申请号：ES92305328

申请日：1992-06-10

Applicant: TORAY INDUSTRIES

Inventor： HATA GO ,  KANEKO TATSUYA ,  KAWAI HIDEKI ,  MUTOH MASATO ,  HASHIMOTO HIDEYUKI

IPC: A61K31/555 ,  A61P35/00 ,  C07F15/00 ,  C07D307/46

Abstract: A platinum(II) complex is represented by the general formula (A), in which R1 represents a hydrocarbon radical having 1 to 10 carbon atoms, R2 and R3 each represent a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, or R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X and Y each represent an ammonia molecule or a monodentate and Y each represent an ammonia molecule or a monodentate amine having 1 to 7 carbon atoms or X and Y, together, amine having 1 to 7 carbon atoms or X and Y, together, may form a bidentate diamine having 2 to 10 carbon atoms. The compounds are useful for treating tumors.

公开(公告)号：DE69216693D1

公开(公告)日：1997-02-27

申请号：DE69216693

申请日：1992-06-10

Applicant: TORAY INDUSTRIES

Inventor： HATA GO ,  KANEKO TATSUYA ,  KAWAI HIDEKI ,  MUTOH MASATO ,  HASHIMOTO HIDEYUKI

IPC: A61K31/555 ,  A61P35/00 ,  C07F15/00 ,  C07D307/46

Abstract: A platinum(II) complex is represented by the general formula (A), in which R1 represents a hydrocarbon radical having 1 to 10 carbon atoms, R2 and R3 each represent a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, or R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X and Y each represent an ammonia molecule or a monodentate and Y each represent an ammonia molecule or a monodentate amine having 1 to 7 carbon atoms or X and Y, together, amine having 1 to 7 carbon atoms or X and Y, together, may form a bidentate diamine having 2 to 10 carbon atoms. The compounds are useful for treating tumors.

公开(公告)号：DK0518645T3

公开(公告)日：1997-02-03

申请号：DK92305328

申请日：1992-06-10

Applicant: TORAY INDUSTRIES

Inventor： HATA GO ,  KANEKO TATSUYA ,  KAWAI HIDEKI ,  MUTOH MASATO ,  HASHIMOTO HIDEYUKI

IPC: A61K31/555 ,  A61P35/00 ,  C07F15/00 ,  C07D307/46

Abstract: A platinum(II) complex is represented by the general formula (A), in which R1 represents a hydrocarbon radical having 1 to 10 carbon atoms, R2 and R3 each represent a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, or R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X and Y each represent an ammonia molecule or a monodentate and Y each represent an ammonia molecule or a monodentate amine having 1 to 7 carbon atoms or X and Y, together, amine having 1 to 7 carbon atoms or X and Y, together, may form a bidentate diamine having 2 to 10 carbon atoms. The compounds are useful for treating tumors.

公开(公告)号：DE69216693T2

公开(公告)日：1997-05-07

申请号：DE69216693

申请日：1992-06-10

Applicant: TORAY INDUSTRIES

Inventor： HATA GO ,  KANEKO TATSUYA ,  KAWAI HIDEKI ,  MUTOH MASATO ,  HASHIMOTO HIDEYUKI

IPC: A61K31/555 ,  A61P35/00 ,  C07F15/00 ,  C07D307/46

Abstract: A platinum(II) complex is represented by the general formula (A), in which R1 represents a hydrocarbon radical having 1 to 10 carbon atoms, R2 and R3 each represent a hydrogen atom or a hydrocarbon radical of 1 to 10 carbon atoms, or R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X R2 and R3, together, may form -(CH2)4- or -(CH2)5-, and X and Y each represent an ammonia molecule or a monodentate and Y each represent an ammonia molecule or a monodentate amine having 1 to 7 carbon atoms or X and Y, together, amine having 1 to 7 carbon atoms or X and Y, together, may form a bidentate diamine having 2 to 10 carbon atoms. The compounds are useful for treating tumors.

公开(公告)号：CA2203768A1

公开(公告)日：1997-03-06

申请号：CA2203768

申请日：1996-08-28

Applicant: TORAY INDUSTRIES

Inventor： KANEKO TATSUYA ,  KANAYAMA NAOHIRO ,  TERAO TOSHIHIKO ,  NARUTO MASANOBU

IPC: A61K38/16 ,  A61K38/19 ,  A61K38/20

Abstract: A fertility agent comprising as the active ingredient a leukocyte migration factor (interleukin 8, monocyte chemotactic factor, etc.) or a leukocyte migration factor inducer (interleukin 1, tumor necrotizing factor, interferon .gamma., platelet-activating factor, endotoxin, etc.). The effects of this drug are based on the fact that a leukocyte migration factor or an inducer thereof is efficacious as a single substance in the promotion of both of the growth of an ovum and the implantation of fertilized ovum. It is broadly usable in various industrial fields as a remedy for human and animal infertility and for veterinary and zootechnical purposes of, for example, promoting the production of industrial animals and conserving rare animal species.

公开(公告)号：JPH049393A

公开(公告)日：1992-01-14

申请号：JP10992290

申请日：1990-04-25

Applicant: TORAY INDUSTRIES

Inventor： NAMITA TAKESHI ,  KANEKO TATSUYA ,  MUTOU MASANORI ,  OKAMOTO YUTAKA

IPC: C07F15/00

Abstract: NEW MATERIAL:A compound shown by formula I {R is group shown by formula II or formula III [R and R are 2-6C aliphatic hydrocarbon or R and R may be bonded to form -(CH2)n-(n is 3-5)]]. EXAMPLE:A compound shown by formula IV. USE:A remedy for tumors. PREPARATION:A compound shown by formula V is reacted with a compound shown by formula VI.