公开(公告)号：CA2487600C

公开(公告)日：2011-07-05

申请号：CA2487600

申请日：2003-04-03

Applicant: TORAY INDUSTRIES

Inventor： TERAMOTO KAZUO ,  YOSHIOKA TOSHIO ,  SHIMAGAKI MASAAKI ,  MATSUNASE TAKEO ,  WATANABE KOJI ,  UEDA YUJI ,  YAMAMOTO YOSHIKI

IPC: B01J20/22 ,  A61K31/7068 ,  A61M1/36 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

Abstract: An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells. An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier. An extracorporeal perfusion column of the invention contains the adsorbent of the invention. A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.

公开(公告)号：CA2487600A1

公开(公告)日：2003-12-11

申请号：CA2487600

申请日：2003-04-03

Applicant: TORAY INDUSTRIES

Inventor： YOSHIOKA TOSHIO ,  MATSUNASE TAKEO ,  YAMAMOTO YOSHIKI ,  SHIMAGAKI MASAAKI ,  TERAMOTO KAZUO ,  WATANABE KOJI ,  UEDA YUJI

IPC: A61M1/36 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

Abstract: An immunosuppressive substance adsorbent capable of selectively adsorbing excess immunosuppressive substances considered to be associated with the multiplication of carcinoma cells directly from humor at high efficiency and capable of safe extracorporeal circulation, which immunosuppressive substanc e adsorbent is useful for the treatment of cancer. In particular, an immunosuppressive substance adsorbent characterized by comprising a water insoluble carrier and, fixed thereto, hydrophilic amino groups. Further, the re is provided an extracorporeal circulation column characterized by being pack ed with the above adsorbent. Still further, there is provided a method of treating cancer characterized in that extracorporeal circulation is performe d by the use of the above extracorporeal circulation column.

公开(公告)号：EP1532993A4

公开(公告)日：2010-09-29

申请号：EP03756106

申请日：2003-04-03

Applicant: TORAY INDUSTRIES

Inventor： TERAMOTO KAZUO ,  YOSHIOKA TOSHIO ,  SHIMAGAKI MASAAKI ,  MATSUNASE TAKEO ,  WATANABE KOJI ,  UEDA YUJI ,  YAMAMOTO YOSHIKI

IPC: A61M1/36 ,  B01J20/26 ,  B01J20/28 ,  B01J20/32

CPC classification number: B01J20/26 ,  A61M1/3679 ,  B01J20/261 ,  B01J20/262 ,  B01J20/265 ,  B01J20/28014 ,  B01J20/28016 ,  B01J20/28023 ,  B01J20/2803 ,  B01J20/28033 ,  B01J20/28045 ,  B01J20/28057 ,  B01J20/3092 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3242 ,  B01J20/3251 ,  B01J20/3272 ,  B01J20/3293 ,  B01J2220/58 ,  B01J2220/60