公开(公告)号：AT375330T

公开(公告)日：2007-10-15

申请号：AT01921580

申请日：2001-04-12

Applicant: UCB PHARMA SA

Inventor： NORMAN TIMOTHY ,  PORTER JOHN ,  HUTCHINSON BRIAN WOODSIDE ,  RATCLIFFE ANDREW JAMES ,  HEAD JOHN ,  ALEXANDER RIKKI PETER ,  LANGHAM BARRY ,  WARRELLOW GRAHAM ,  ARCHIBALD SARAH CATHERINE ,  LINSLEY JANEEN

IPC: C07D213/81 ,  A61K31/198 ,  A61K31/223 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4436 ,  A61K31/4545 ,  A61K31/472 ,  A61P1/04 ,  A61P3/10 ,  A61P11/06 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P21/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  C07C225/20 ,  C07C229/36 ,  C07D217/22 ,  C07D409/12 ,  C07D471/04

Abstract: Enamine derivatives of formula (1) are described:whereinR is a group Ar L Ar Alk- in, which Ar is an aromatic or heteroaromatic group, L is a covalent bond or a linker atom or group, Ar is an arylene or heteroarylene group and Alk is a chain -CH2-CH(R)-, -CH=C(R)- orin which R is a carboxylic acid or a derivative or biostere thereof;R is a hydrogen atom or a C1-6alkyl group;Cy is a cycloaliphatic or heterocycloaliphatic ring in which X is a N atom or a C(R ) group;R is a oxo, thioxo, or imino group;R and R is each a hydrogen atom or optional substituent; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.