公开(公告)号：ES2382879T3

公开(公告)日：2012-06-14

申请号：ES06794542

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： NORMAN TIMOTHY ,  DE CANDOLE BENJAMIN ,  ALI MEZHER

IPC: A61K47/48 ,  C08F4/00 ,  C08F8/04 ,  C08F8/30 ,  C08F220/58

Abstract: Un conjugado de anticuerpo - polímero de peine que tiene la fórmula (Ia) o (Ib) : en las que: y es 1, 2 o 3; m es 1, 2, 3, 4, 5, 6, 7, 8, 9 o 10; 1B1 representa un halógeno; B2 representa H o un halógeno; A representa el residuo de un anticuerpo o uno de sus fragmentos; L representa un grupo enlazador; Y representa un grupo espaciador; y X representa un resto de polímero de peine que comprende w equivalentes de una o más moléculas efectoras y z equivalentes de uno o más restos solubilizantes en agua, en la que X comprende los componentes de fórmula (III) y (IV) en cualquier orden: en las que: w es al menos 1; z es 0 o mayor; T no está o es un grupo enlazador; W es una molécula efectora; Z es un resto solubilizante en agua; M es NH u O; y R1 es metilo o H.

公开(公告)号：AT546160T

公开(公告)日：2012-03-15

申请号：AT06794542

申请日：2006-09-12

Applicant: UCB PHARMA SA

Inventor： NORMAN TIMOTHY ,  DE CANDOLE BENJAMIN ,  ALI MEZHER

IPC: A61K47/48 ,  C08F4/00 ,  C08F8/04 ,  C08F8/30 ,  C08F220/58

Abstract: The present invention provides a process for producing a comb polymer comprising the steps of: a) providing: (i) (w+z) molar equivalents of a monomer; (ii) one molar equivalent of an initiator compound of formula (IX), wherein B3 represents a halogen, B2 represents H or a halogen, Y1 represents a group capable of attaching the residue of an antibody or fragment thereof or capable of being converted into such a group, L represents a linker group, y is 1, 2 or 3, w is at least 1 and z is 0 or greater; (iii) a catalyst capable of catalysing the polymerization of a plurality of the monomers to produce the comb polymer; and b) causing the catalyst to catalyse, in combination with the initiator, the polymerization of a plurality of the monomers (i) to produce the comb polymer.

公开(公告)号：AT375330T

公开(公告)日：2007-10-15

申请号：AT01921580

申请日：2001-04-12

Applicant: UCB PHARMA SA

Inventor： NORMAN TIMOTHY ,  PORTER JOHN ,  HUTCHINSON BRIAN WOODSIDE ,  RATCLIFFE ANDREW JAMES ,  HEAD JOHN ,  ALEXANDER RIKKI PETER ,  LANGHAM BARRY ,  WARRELLOW GRAHAM ,  ARCHIBALD SARAH CATHERINE ,  LINSLEY JANEEN

IPC: C07D213/81 ,  A61K31/198 ,  A61K31/223 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4436 ,  A61K31/4545 ,  A61K31/472 ,  A61P1/04 ,  A61P3/10 ,  A61P11/06 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P21/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  C07C225/20 ,  C07C229/36 ,  C07D217/22 ,  C07D409/12 ,  C07D471/04

Abstract: Enamine derivatives of formula (1) are described:whereinR is a group Ar L Ar Alk- in, which Ar is an aromatic or heteroaromatic group, L is a covalent bond or a linker atom or group, Ar is an arylene or heteroarylene group and Alk is a chain -CH2-CH(R)-, -CH=C(R)- orin which R is a carboxylic acid or a derivative or biostere thereof;R is a hydrogen atom or a C1-6alkyl group;Cy is a cycloaliphatic or heterocycloaliphatic ring in which X is a N atom or a C(R ) group;R is a oxo, thioxo, or imino group;R and R is each a hydrogen atom or optional substituent; provided that Cy is not a cyclobutenedione group; and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.