-
1.发明申请
公开(公告)号：WO2009015485A1
公开(公告)日：2009-02-05
申请号：PCT/CA2008001415
申请日：2008-08-01
Applicant: UNIV HEALTH NETWORK , PAULS HEINZ W , FORREST BRYAN T , SAMPSON PETER BRENT , LIU YONG , LAUFER RADOSLAW , LANG YUNHUI , FEHER MIKIOS , YAO YI , PAN GUOHUA
Inventor： PAULS HEINZ W , FORREST BRYAN T , SAMPSON PETER BRENT , LIU YONG , LAUFER RADOSLAW , LANG YUNHUI , FEHER MIKIOS , YAO YI , PAN GUOHUA
IPC: C07D211/58 , A61K31/17 , A61K31/397 , A61K31/40 , A61K31/445 , A61P3/10 , A61P35/00 , C07C275/32 , C07D205/04 , C07D207/50 , C07D211/56
CPC classification number: C07D211/58 , C07C275/36 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12
Abstract: A CPTl inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
Abstract translation: CPT1抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。 治疗患有癌症的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。
-
公开(公告)号：CA2680366C
公开(公告)日：2016-06-21
申请号：CA2680366
申请日：2008-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： PAULS HEINZ W , SAMPSON PETER BRENT , FORREST BRYAN T , LAUFER RADOSLAW , LIU YONG , FEHER MIKLOS , YAO YI , PAN GUOHUA
IPC: C07C275/28 , A61K31/195 , A61K31/34 , A61K31/381 , A61K31/41 , A61K31/44 , A61K31/495 , A61P35/00 , C07C233/52 , C07C233/83 , C07C237/42 , C07C275/06 , C07C307/06 , C07C307/10 , C07C311/19 , C07C311/29 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D277/44 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04
Abstract: A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
-
公开(公告)号：WO2008109991A8
公开(公告)日：2008-12-18
申请号：PCT/CA2008000440
申请日：2008-03-06
Applicant: UNIV HEALTH NETWORK , PAULS HEINZ W , SAMPSON PETER BRENT , FORREST BRYAN T , LAUFER RADOSLAW , LIU YONG , FEHER MIKLOS , YAO YI , PAN GUOHUA
Inventor： PAULS HEINZ W , SAMPSON PETER BRENT , FORREST BRYAN T , LAUFER RADOSLAW , LIU YONG , FEHER MIKLOS , YAO YI , PAN GUOHUA
IPC: C07C275/28 , A61K31/195 , A61K31/34 , A61K31/381 , A61K31/41 , A61K31/44 , A61K31/495 , A61P35/00 , C07C233/52 , C07C233/83 , C07C237/42 , C07C275/06 , C07C307/06 , C07C307/10 , C07C311/19 , C07C311/29 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D277/44 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04
CPC classification number: C07D409/06 , C07C1/26 , C07C17/10 , C07C2529/40 , C07D207/325 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D263/34 , C07D277/48 , C07D295/215 , C07D307/24 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07C9/00 , C07C19/075
Abstract: A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
Abstract translation: CPT抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。 治疗患有癌症的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。
-
Patent Agency Ranking
公开(公告)号：CA2694724A1
公开(公告)日：2009-02-05
申请号：CA2694724
申请日：2008-08-01
Applicant: UNIV HEALTH NETWORK
Inventor： FEHER MIKLOS , FORREST BRYAN T , LANG YUNHUI , LAUFER RADOSLAW , LIU YONG , PAN GUOHUA , PAULS HEINZ W , SAMPSON PETER BRENT , YAO YI
IPC: C07D211/58 , A61K31/17 , A61K31/397 , A61K31/40 , A61K31/445 , A61P3/10 , A61P35/00 , C07C275/32 , C07D205/04 , C07D207/50 , C07D211/56
Abstract: A CPTl inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
-
公开(公告)号：CA2680058C
公开(公告)日：2019-04-16
申请号：CA2680058
申请日：2008-03-07
Applicant: UNIV HEALTH NETWORK
Inventor： MAK TAK WAH , PAN GUOHUA , YAO YI , ZAUGG KATHRIN
IPC: C07H21/02 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P35/00 , C12N9/10 , C12N15/11 , C12N15/113 , C12N15/54 , C12Q1/02 , C12Q1/48 , G01N33/53 , G01N33/68
Abstract: This invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for treating tumors by inhibiting the activity of CPT1C. The methods and compositions can additionally include inhibition of glycolysis.
-
公开(公告)号：CA2694724C
公开(公告)日：2017-09-12
申请号：CA2694724
申请日：2008-08-01
Applicant: UNIV HEALTH NETWORK
Inventor： FEHER MIKLOS , FORREST BRYAN T , LANG YUNHUI , LAUFER RADOSLAW , LIU YONG , PAN GUOHUA , PAULS HEINZ W , SAMPSON PETER BRENT , YAO YI
IPC: C07D211/58 , A61K31/17 , A61K31/397 , A61K31/40 , A61K31/445 , A61P3/10 , A61P35/00 , C07C275/32 , C07D205/04 , C07D207/50 , C07D211/56
Abstract: A CPT1 inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
-
公开(公告)号：CA2680366A1
公开(公告)日：2008-09-18
申请号：CA2680366
申请日：2008-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： LIU YONG , LAUFER RADOSLAW , FEHER MIKLOS , FORREST BRYAN T , SAMPSON PETER BRENT , YAO YI , PAULS HEINZ W , PAN GUOHUA
IPC: C07C275/28 , A61K31/195 , A61K31/34 , A61K31/381 , A61K31/41 , A61K31/44 , A61K31/495 , A61P35/00 , C07C233/52 , C07C233/83 , C07C237/42 , C07C275/06 , C07C307/06 , C07C307/10 , C07C311/19 , C07C311/29 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D277/44 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04
Abstract: A CPT inhibitor compound is represented by Structural Formula (I) or a ph armaceutically acceptable salt thereof: or a pharmaceutically acceptable sal t thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A meth od of treating a subject having cancer comprises administering to the subjec t a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
-
公开(公告)号：CA2680058A1
公开(公告)日：2008-09-12
申请号：CA2680058
申请日：2008-03-07
Applicant: UNIV HEALTH NETWORK
Inventor： ZAUGG KATHRIN , PAN GUOHUA , YAO YI , MAK TAK W
IPC: C07H21/02 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P35/00 , C12N9/10 , C12N15/113 , C12N15/54 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/53 , G01N33/68
Abstract: This invention relates to compositions and methods for cancer therapeutic s. In particular, the present invention provides compositions and methods fo r treating tumors by inhibiting the activity of CPT1C. The methods and compo sitions can additionally include inhibition of glycolysis.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.041 seconds)
