公开(公告)号：EP3030891A4

公开(公告)日：2017-05-10

申请号：EP14835240

申请日：2014-08-05

Applicant: UNIV NORTHEASTERN

Inventor： LEE JIN YOUNG ,  BUSNAINA AHMED ,  CHO HANCHUL ,  SOMU SIVASUBRAMANIAN

IPC: G01N27/327 ,  C12Q1/54 ,  C12Q1/58

CPC classification number: G01N27/4146 ,  B82Y15/00 ,  C12Q1/005 ,  C12Q1/006 ,  C12Q1/26 ,  C12Q1/54 ,  C12Q1/58 ,  G01N27/127 ,  H01L29/401

Abstract: A single-walled carbon nanotube-based micron scale multiplex biosensor is provided that enables the detection of glucose, lactate, and urea. The sensor is based on modification of semiconducting single-walled carbon nanotubes using a linker that non-covalently associates with the nanotubes and covalently couples to an enzyme. Reaction of a physiological substrate with the enzyme results in increased resistance of the nanotubes within the sensor. The sensor is suitable for use in patient monitoring, particularly in a clinical setting. Incorporation of read out electronics and an RF signal generator into the sensor device enables it to communicate to a relay station or remote receiver. Methods are also provided for fabricating the biosensor device and using the device for detection.

Abstract translation: 提供了一种单壁碳纳米管基微米级多重生物传感器，能够检测葡萄糖，乳酸盐和尿素。 该传感器基于半导体单壁碳纳米管的修饰，其使用与纳米管非共价缔合并共价连接至酶的接头。 生理底物与酶的反应导致传感器内纳米管的阻力增加。 该传感器适用于患者监护，特别是在临床环境中。 将读出电子器件和射频信号发生器集成到传感器设备中，使其能够与中继站或远程接收器通信。 还提供了制造生物传感器装置和使用该装置进行检测的方法。

公开(公告)号：EP2745102A4

公开(公告)日：2015-05-27

申请号：EP12853154

申请日：2012-08-20

Applicant: UNIV NORTHEASTERN

Inventor： BUSNAINA AHMED ,  JUNG YUNG JOON ,  SOMU SIVASUBRAMANIAN ,  DATAR ANIKET ,  KIM YOUNG LAE

IPC: G01N27/26 ,  G01N27/12 ,  G01N33/00

CPC classification number: G01N27/26 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/75 ,  G01N21/77 ,  G01N27/127 ,  G01N27/414 ,  G01N27/4146 ,  G01N33/0044 ,  H01L51/0048 ,  H01L51/0049 ,  H01L51/0575

Abstract: A carbon nanotube-based micron scale chemical sensor or sensor array is provided that enables the remote detection of hydrogen sulfide and other chemicals in a gas stream. The sensor is suitable for use in harsh environments of high temperature and pressure such as those encountered during petrochemical exploration and recovery. Multiplex sensor devices detect two or more chemical agents simultaneously, or they can detect conditions such as pressure, salinity, humidity, pH, or scale-forming ions. Incorporation of read out electronics and an RF signal generator into the sensor device enables it to communicate to a relay station or receiver for 3D mapping or other analysis. Methods are also provided for fabricating the chemical sensor device and using the device for detection.

公开(公告)号：WO2009008929A8

公开(公告)日：2010-08-05

申请号：PCT/US2008004584

申请日：2008-04-09

Applicant: UNIV NORTHEASTERN ,  SOMU SIVASUBRAMANIAN ,  BUSNAINA AHMED ,  MCGRUER NICOL ,  RYAN PETER ,  ADAMS GEORGE G ,  XIONG XUGANG ,  KIM TAEHOON

Inventor： SOMU SIVASUBRAMANIAN ,  BUSNAINA AHMED ,  MCGRUER NICOL ,  RYAN PETER ,  ADAMS GEORGE G ,  XIONG XUGANG ,  KIM TAEHOON

IPC: H01L51/00

CPC classification number: H01H11/04 ,  B82Y10/00 ,  B82Y40/00 ,  G11C11/50 ,  G11C13/025 ,  G11C2213/16 ,  H01L51/0048 ,  H01L51/0575 ,  H01L51/0591 ,  Y10S977/89 ,  Y10S977/943

Abstract: A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state.

Abstract translation: 提供了用于存储器件和微处理器的非易失性双稳态纳米机电开关。 开关采用碳纳米管作为驱动元件。 已经开发了用于制造具有一个单壁碳纳米管作为致动器的纳米开关的方法。 对于每个状态，可以使用相同的低电压来实现两种不同状态的致动。

公开(公告)号：WO2008054411A8

公开(公告)日：2008-07-24

申请号：PCT/US2006045911

申请日：2006-12-01

Applicant: UNIV NORTHEASTERN ,  BUSNAINA AHMED ,  MCGRUER NICOL E

Inventor： BUSNAINA AHMED ,  MCGRUER NICOL E

IPC: H01L51/00

CPC classification number: C01B31/0253 ,  B81B2201/0214 ,  B81C1/00031 ,  B81C1/00206 ,  B82B3/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/168 ,  C01B2202/34 ,  C01B2202/36 ,  Y10T428/2462 ,  Y10T428/2918

Abstract: The present invention provides methods and tools for directed assembly of nanoelements across a large area using a nanosubstrate. The nanosubstrate has a substrate layer, an adhesive layer, a conductive layer, and an insulating layer that is interrupted by one or more nanotrenches or nanowells having a width of at least 20 nm. The nanosubstrate allows the rapid assembly of linear assemblies and arrays of single walled carbon nanotubes and nanoparticles by DC electrophoresis. The density of nanoelements assembled can be controlled by varying the voltage and trench size. Functionalized nanoparticles can be assembled into arrays useful, e.g., as biosensors.

Abstract translation: 本发明提供了使用纳米基底在大面积上直接组装纳米元件的方法和工具。 纳米基底具有基底层，粘合剂层，导电层和被一个或多个宽度为至少20nm的纳米沟槽或纳米孔中断的绝缘层。 纳米基底允许通过直流电泳快速装配线性组件和单壁碳纳米管阵列和纳米粒子。 纳米元件的密度可以通过改变电压和沟槽尺寸来控制。 功能化的纳米粒子可以组装成有用的阵列，例如作为生物传感器。

公开(公告)号：WO2014143931A3

公开(公告)日：2015-11-05

申请号：PCT/US2014028118

申请日：2014-03-14

Applicant: UNIV NORTHEASTERN

Inventor： MALIMA ASANTERABI ,  BUSNAINA AHMED ,  SIAVOSHI SALOME ,  SOMU SIVASUBRAMANIAN ,  YILMAZ CIHAN ,  MUSACCHIO TIZIANA ,  UPPONI JAYDEV ,  TORCHILIN VLADIMIR

IPC: G01N33/00 ,  A61M5/00 ,  C12M1/34 ,  C12Q1/00 ,  G01N33/566

CPC classification number: G01N33/54346 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/6852 ,  B82Y30/00

Abstract: Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described.

Abstract translation: 描述了作为生物传感器的纳米基质，制备这种纳米基质的方法，以及使用这种纳米基质来检测生物标志物的方法。

公开(公告)号：WO2015061299A2

公开(公告)日：2015-04-30

申请号：PCT/US2014061542

申请日：2014-10-21

Applicant: UNIV NORTHEASTERN

Inventor： MALIMA ASANTERABI ,  BUSNAINA AHMED

IPC: G01N33/53

CPC classification number: G01N33/558 ,  B01L3/502 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/0627 ,  B01L2300/0848 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/12 ,  G01N33/54346 ,  G01N33/5438 ,  G01N33/54386

Abstract: An immunosensing device includes a hub mountable to a device for fluid collection, such as a syringe, sample collection container, or vacuum collection container, and a biosensor mounted to the hub. The biosensor includes a biosensor active area in fluid communication with a fluid passage within the hub. The biosensor active area includes nanoelements functionalized with one or more antibodies or antigen binding fragments thereof for contact with a fluid in the fluid passage. The biosensor active area can include multiple regions each including nanoelements functionalized with a different antibody or antigen binding fragment thereof to detect multiple biomarkers. The biosensor, separately or attached to the hub, can be inserted in a biomarker reader for detection of a biomarker in the fluid.

Abstract translation: 免疫感测装置包括可安装到用于流体收集的装置的毂，例如注射器，样品收集容器或真空收集容器以及安装到毂的生物传感器。 生物传感器包括与轮毂内的流体通道流体连通的生物传感器有效区域。 生物传感器活性区域包括用一种或多种抗体或其抗原结合片段官能化的纳米元件，用于与流体通道中的流体接触。 生物传感器活性区域可以包括多个区域，每个区域包括用不同抗体或其抗原结合片段功能化的纳米元件，以检测多个生物标志物。 单独或附接到轮毂的生物传感器可以插入生物标志物读数器中，以检测流体中的生物标志物。

公开(公告)号：WO2016094384A3

公开(公告)日：2016-09-15

申请号：PCT/US2015064459

申请日：2015-12-08

Applicant: UNIV NORTHEASTERN

Inventor： SIRMAN ASLI ,  HALDER ADITI ,  BUSNAINA AHMED

IPC: B05D1/18 ,  B82Y40/00

CPC classification number: B22F7/04 ,  B05D1/202 ,  B22F2007/042 ,  B82Y30/00

Abstract: A technique for rapid large-scale assembly of monolayers and multilayers of nanoelements on a variety of different substrates is provided. The technique is based on self-assembly of nanoelements suspended at the interface between a polar solvent and a nonpolar solvent. The layer of nanoelements is collected onto a substrate at a shallow angle, forming a continuous monolayer or multilayer of nanoparticles which can be optionally patterned or can be transferred to other substrates to form components of nanoelectronics, optical devices, and sensors.

Abstract translation: 提供了用于在各种不同衬底上快速大规模组装纳米元件的单层和多层的技术。 该技术基于悬浮在极性溶剂和非极性溶剂之间界面上的纳米元件的自组装。 将纳米元件层以浅角度收集到衬底上，形成纳米颗粒的连续单层或多层，其可以任选地图案化或者可以转移到其他衬底以形成纳米电子器件，光学器件和传感器的组件。

公开(公告)号：WO2014005147A2

公开(公告)日：2014-01-03

申请号：PCT/US2013048948

申请日：2013-07-01

Applicant: UNIV NORTHEASTERN

Inventor： BUSNAINA AHMED ,  YILMAZ CIHAN ,  KIM TAEHOON ,  SOMU SIVASUMBRAMANIAN

IPC: H01L21/465

CPC classification number: C25D13/18 ,  B23K31/00 ,  B81B2203/0361 ,  B81B2207/056 ,  B81C1/00111 ,  B81C2201/0187 ,  C25D3/48 ,  C25D5/02 ,  C25D13/02 ,  C25D13/12 ,  C25D13/22 ,  H01L21/2885 ,  H01L21/76879 ,  H01L21/76885 ,  H01L2221/1094

Abstract: A variety of homogeneous or layered hybrid nanostructures are fabricated by electric field-directed assembly of nanoelements. The nanoelements and the fabricated nanostructures can be conducting, semi-conducting, or insulating, or any combination thereof. Factors for enhancing the assembly process are identified, including optimization of the electric field and combined dielectrophoretic and electrophoretic forces to drive assembly. The fabrication methods are rapid and scalable. The resulting nanostructures have electrical and optical properties that render them highly useful in nanoscale electronics, optics, and biosensors.

Abstract translation: 各种均匀或层状混合纳米结构通过纳米元件的电场定向组装制造。 纳米元件和制造的纳米结构可以是导电的，半导电的或绝缘的，或其任何组合。 确定了增强装配过程的因素，包括电场的优化以及组合介电泳和电泳力的组合。 制造方法快速且可扩展。 由此产生的纳米结构具有电气和光学特性，使其在纳米级电子，光学和生物传感器中非常有用。

公开(公告)号：EP2867018A4

公开(公告)日：2016-06-08

申请号：EP13810095

申请日：2013-07-01

Applicant: UNIV NORTHEASTERN

Inventor： BUSNAINA AHMED ,  YILMAZ CIHAN ,  KIM TAEHOON ,  SOMU SIVASUMBRAMANIAN

IPC: B32B9/00 ,  B81C1/00 ,  C25D5/02 ,  C25D13/02 ,  H01L21/288 ,  H01L21/76 ,  H01L21/768

CPC classification number: C25D13/18 ,  B23K31/00 ,  B81B2203/0361 ,  B81B2207/056 ,  B81C1/00111 ,  B81C2201/0187 ,  C25D3/48 ,  C25D5/02 ,  C25D13/02 ,  C25D13/12 ,  C25D13/22 ,  H01L21/2885 ,  H01L21/76879 ,  H01L21/76885 ,  H01L2221/1094

Abstract: A variety of homogeneous or layered hybrid nanostructures are fabricated by electric field-directed assembly of nanoelements. The nanoelements and the fabricated nanostructures can be conducting, semi-conducting, or insulating, or any combination thereof. Factors for enhancing the assembly process are identified, including optimization of the electric field and combined dielectrophoretic and electrophoretic forces to drive assembly. The fabrication methods are rapid and scalable. The resulting nano structures have electrical and optical properties that render them highly useful in nanoscale electronics, optics, and biosensors.

Abstract translation: 各种均相或非层状混合纳米结构的由纳米元件的电场指导组装而制造的。 纳米元件和制造的纳米结构可被导通，半导电或绝缘，或它们的任何组合。 用于提高组装过程的因素进行确定，包括电场的优化和组合介电电泳和电泳力，以驱动组件。 制作方法是快速和可扩展性。 所产生的纳米结构具有电学和光学性质做了使它们在纳米电子学，光学，和生物传感器非常有用。

公开(公告)号：EP2647035A4

公开(公告)日：2015-04-08

申请号：EP11845971

申请日：2011-11-29

Applicant: UNIV NORTHEASTERN

Inventor： SIRMAN ASLI ,  BUSNAINA AHMED ,  YILMAZ CIHAN ,  HUANG JUN ,  SOMU SIVASUBRAMANIAN

IPC: H01L21/20 ,  B82Y40/00 ,  C25D13/00 ,  H01L21/02

CPC classification number: C25D13/22 ,  B82Y30/00 ,  B82Y40/00 ,  C09D5/4407 ,  C09D5/4488 ,  C09D125/06 ,  C25D13/04 ,  C25D13/12 ,  C25D13/20 ,  H01L21/0243 ,  H01L21/0259 ,  H01L21/02628 ,  H01L29/0665 ,  H05K1/0213 ,  H05K1/0306 ,  H05K1/092 ,  H05K3/1258 ,  Y10S977/882 ,  Y10S977/892

Abstract: A method for high rate assembly of nanoelements into two-dimensional void patterns on a non-conductive substrate surface utilizes an applied electric field to stabilize against forces resulting from pulling the substrate through the surface of a nanoelement suspension. The electric field contours emanating from a conductive layer in the substrate, covered by an insulating layer, are modified by a patterned photoresist layer, resulting in an increased driving force for nanoelements to migrate from a liquid suspension to voids on a patterned substrate having a non-conductive surface. The method can be used for the production of microscale and nanoscale circuits, sensors, and other electronic devices.