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    SOFT IONIZATION SYSTEM AND METHOD OF USE THEREOF
    1.
    发明申请
    SOFT IONIZATION SYSTEM AND METHOD OF USE THEREOF 审中-公开

    公开(公告)号：WO2017214718A3

    公开(公告)日：2017-12-21

    申请号：PCT/CA2017/050713

    申请日：2017-06-09

    Applicant: UNIVERSITY HEALTH NETWORK ,  ST. MICHAEL'S HOSPITAL

    Inventor： ZARRINE-AFSAR, Arash ,  GINSBERG, Howard Joeseph ,  WOOLMAN, Michael

    IPC: H01J49/10 ,  H01J27/24 ,  H01J49/04

    Abstract: Methods and systems are provided for ionizing molecules for the purpose of analysis by mass spectrometry, in which gaseous material from a sample substrate is generated using laser desorption. The laser is provided having a pulse range of about 1-1000 picoseconds to produce the gaseous material. The gaseous material is heated to generate ions from the molecules present in the gaseous material where the amount of heat that is applied is in the temperature range of 45 °C to 250 °C and the applied heat results in soft ionization of the molecules. The ionized molecules are transported to a mass spectrometer for analysis.

    SYSTEM AND METHOD FOR OPTIMIZED MASS SPECTROMETRY ANALYSIS
    4.
    发明申请
    SYSTEM AND METHOD FOR OPTIMIZED MASS SPECTROMETRY ANALYSIS 审中-公开
    用于优化质谱分析的系统和方法

    公开(公告)号：WO2017049403A1

    公开(公告)日：2017-03-30

    申请号：PCT/CA2016/051112

    申请日：2016-09-22

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： ZARRINE-AFSAR, Arash ,  JAFFRAY, David A. ,  TATA, Alessandra ,  WOOLMAN, Michael ,  VITKIN, I. Alex

    IPC: G01N27/00 ,  A61B10/02 ,  A61B18/20 ,  G01N21/21 ,  H01J49/04 ,  H01J49/16 ,  G01N1/30

    CPC classification number: G01N21/21 ,  A61B10/0233 ,  A61B18/20 ,  H01J49/0004

    Abstract: Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments, polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.

    Abstract translation: 本文描述了用于通过质谱法获得用于分析的组织样品的系统和方法。 可以使用来自不同于质谱的第一成像模态的图像数据在组织中鉴定感兴趣区域。 可以使用来自与感兴趣区域相关的采样位置的组织取样器获取至少一个组织样本。 可以使用质谱仪对采集的组织样品产生质谱数据。 在一些实施例中，可以在组织切片上使用偏振测定法，可以在相同的组织切片上进行质谱分析，然后可以在相同的组织切片上进行H＆E成像。

    SYSTEM AND METHOD FOR ENHANCED MASS SPECTROMETRY IMAGING
    5.
    发明申请
    SYSTEM AND METHOD FOR ENHANCED MASS SPECTROMETRY IMAGING 审中-公开
    用于增强大量光谱成像的系统和方法

    公开(公告)号：WO2016090471A1

    公开(公告)日：2016-06-16

    申请号：PCT/CA2015/051282

    申请日：2015-12-08

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： ZARRINE-AFSAR, Arash ,  JAFFRAY, David A.

    IPC: G01N27/00 ,  A61K51/04 ,  A61K49/00

    CPC classification number: A61K49/106 ,  A61K49/00 ,  A61K49/0438 ,  G01N27/00 ,  G01N33/4833 ,  G01N33/58 ,  G01N2458/15 ,  G01N2560/00 ,  H01J49/0004 ,  H01J49/105

    Abstract: Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. A sampling unit can also be provided to acquire a sample from the tissue. The sample can then be provided to a high sensitivity analysis platform, such as a mass analyzer, to analyze the sample and determine a distribution of the exogenous agent or a by-product of the exogenous agent within the tissue based on the analysis. The analysis platform can then identify the region of interest based on the distribution of the exogenous agent or the distribution of the by-product.

    Abstract translation: 本文描述了用于使用质谱法鉴定组织中的感兴趣区域的系统和方法的各种实施方案。 可以提供药剂施用组分以向组织施用外源性试剂。 还可以提供采样单元以从组织获取样品。 然后将样品提供给诸如质量分析仪的高灵敏度分析平台，以分析样品并基于分析确定组织内的外源性试剂或副产物的分布。 然后，分析平台可以基于外源性代理的分布或副产物的分布来识别感兴趣的区域。

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