公开(公告)号：US20230331777A1

公开(公告)日：2023-10-19

申请号：US18015927

申请日：2021-04-07

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Damith Gomika Udugamasooriya ,  Bin Guo ,  Satya Prakash Shukla ,  Kwang Bog Cho

IPC: C07K7/06 ,  A61P31/14 ,  C07K7/02

CPC classification number: C07K7/06 ,  A61P31/14 ,  C07K7/02 ,  A61K38/00

Abstract: Embodiments of the present disclosure pertain to methods of blocking virus entry into cells by associating the cells with an anti-viral peptoid to result in the blocking of virus entry into the cells. Additional embodiments of the present disclosure pertain to methods of treating or preventing a viral infection in a subject by administering an anti-viral peptoid composition to the subject to result in the blocking of virus entry into the cells of the subject. Further embodiments of the present disclosure pertain to anti-viral peptoids and compositions that include the anti-viral peptoids of the present disclosure. Additional embodiments of the present disclosure pertain to the use of the anti-viral peptoids and compositions to block virus entry into cells for numerous purposes, such as treating or preventing viral infections.

公开(公告)号：US20230257420A1

公开(公告)日：2023-08-17

申请号：US18011649

申请日：2021-06-22

Applicant: University of Houston System

Inventor： Bin Guo ,  Damith Gomika Udugamasooriya ,  Xinli Liu ,  Satya Prakash Shukla ,  Kwang Bog Cho ,  Xue Zhou

IPC: C07K7/06 ,  A61K47/64 ,  A61P25/00

CPC classification number: C07K7/06 ,  A61K47/645 ,  A61P25/00

Abstract: Compounds disclosed herein have been shown to bind to the transferrin receptor making them capable of crossing the blood-brain barrier (BBB) and useful for treating diseases or disorders of the brain, such as cancer, ischemic stroke, Alzheimer's disease, or Parkinson's disease.