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公开(公告)号：US12006542B2
公开(公告)日：2024-06-11
申请号：US16620571
申请日：2018-06-11
Applicant: University of Houston System
Inventor： Shoujun Xu , Qiongzheng Hu , Yuhong Wang
IPC: C12Q1/6811 , B01L3/00 , B01L7/00 , C12Q1/6816 , C12Q1/6874 , C12Q1/6806 , C12Q1/6818
CPC classification number: C12Q1/6874 , B01L3/502761 , B01L7/52 , B01L2200/0663 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/18 , B01L2400/0439 , C12Q1/6806 , C12Q1/6818
Abstract: Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.
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2.发明授权公开(公告)号：US10112169B2
公开(公告)日：2018-10-30
申请号：US14524207
申请日：2014-10-27
Applicant: University of Houston System
Inventor： Shoujun Xu , Lashan De Silva , Li Yao
Abstract: A system and method for resolving and/or mechanically manipulating molecular bonds. A method for resolving molecular bonds includes applying ultrasound to molecules to be manipulated. A magnetic signal associated with the molecules is measured. Whether ultrasound causes dissolution of the bonds of the molecules is determined based on measurements of the magnetic signal.
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公开(公告)号：US09778249B2
公开(公告)日：2017-10-03
申请号：US15514683
申请日：2015-09-25
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： Shoujun Xu , Qiongzheng Hu , Yuhong Wang , Te-Wei Tsai
IPC: G01N33/553 , C12Q1/68 , G01N33/53
CPC classification number: G01N33/5308 , C12Q1/6804 , G01N33/54333 , G01N2500/04 , G01N2500/20
Abstract: Methods of quantifying the efficiency of a drug molecule for its targeted receptor, using a differential binding force to quantify the efficiency of a drug molecule to its targeted receptor.
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Patent Agency Ranking
公开(公告)号：US20240287603A1
公开(公告)日：2024-08-29
申请号：US18653029
申请日：2024-05-02
Applicant: University of Houston system
Inventor： Shoujun Xu , Qiongzheng Hu , Yuhong Wang
IPC: C12Q1/6874 , B01L3/00 , B01L7/00 , C12Q1/6806 , C12Q1/6818
CPC classification number: C12Q1/6874 , B01L3/502761 , B01L7/52 , B01L2200/0663 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/18 , B01L2400/0439 , C12Q1/6806 , C12Q1/6818
Abstract: Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.
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公开(公告)号：US20230160003A1
公开(公告)日：2023-05-25
申请号：US16620571
申请日：2018-06-11
Applicant: University of Houston System
Inventor： Shoujun Xu , Qiongzheng Hu , Yuhong Wang
IPC: C12Q1/6874 , B01L3/00 , B01L7/00
CPC classification number: C12Q1/6874 , B01L3/502761 , B01L7/52 , C12Q1/6806
Abstract: Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.
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6.发明申请SYSTEM AND METHOD FOR ULTRASOUND IDENTIFICATION AND MANIPULATION OF MOLECULAR INTERACTIONS 审中-公开用于超声波识别和操纵分子相互作用的系统和方法公开(公告)号：US20150117156A1
公开(公告)日：2015-04-30
申请号：US14524207
申请日：2014-10-27
Applicant: University of Houston System
Inventor： Shoujun Xu , Lashan De Silva , Li Yao
CPC classification number: B01J19/10 , G01R33/1269
Abstract: A system and method for resolving and/or mechanically manipulating molecular bonds. A method for resolving molecular bonds includes applying ultrasound to molecules to be manipulated. A magnetic signal associated with the molecules is measured. Whether ultrasound causes dissolution of the bonds of the molecules is determined based on measurements of the magnetic signal.
Abstract translation: 用于分解和/或机械操作分子键的系统和方法。 解决分子键的方法包括将超声应用于待操作的分子。 测量与分子相关的磁信号。 基于磁信号的测量来确定超声是否导致分子的键的溶解。
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7.发明授权公开(公告)号：US12085534B2
公开(公告)日：2024-09-10
申请号：US16968535
申请日：2019-02-06
Applicant: University of Houston System
Inventor： Shoujun Xu , Yuhong Wang , Haina Jia , Heng Yin , Yujia Mao
CPC classification number: G01N27/72 , B06B1/0207 , B06B1/0622 , B06B1/0651 , G01N33/15 , B06B2201/77
Abstract: A method of measuring dissociation of the biomolecular bonds in one or multiple sample wells using super-resolution force spectroscopy (SURFS). SURFS utilizes precise ultrasound radiation to exert an acoustic radiation force on the biomolecular bonds labeled with magnetic particles. The force-induced dissociation of the protein bonds labeled with magnetic particles may be measured as a reduced magnetic signal by a magnetic sensor. The force resolution allows for differentiating biomolecular bonds with an extremely high level of precision. The biomolecular bonds include protein-protein, protein-nucleic acid, nucleic acid-nucleic acid, small molecule-protein, and small molecule-nucleic acid interactions.
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8.发明申请公开(公告)号：US20210041395A1
公开(公告)日：2021-02-11
申请号：US16968535
申请日：2018-02-08
Applicant: University of Houston System
Inventor： Shoujun Xu , Yuhong Wang , Haina Jia , Heng Yin , Yujia Mao
Abstract: A method of measuring dissociation of the biomolecular bonds in one or multiple sample wells using super-resolution force spectroscopy (SURFS). SURFS utilizes precise ultrasound radiation to exert an acoustic radiation force on the biomolecular bonds labeled with magnetic particles. The force-induced dissociation of the protein bonds labeled with magnetic particles may be measured as a reduced magnetic signal by a magnetic sensor. The force resolution allows for differentiating biomolecular bonds with an extremely high level of precision. The biomolecular bonds include protein-protein, protein-nucleic acid, nucleic acid-nucleic acid, small molecule-protein, and small molecule-nucleic acid interactions.
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