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公开(公告)号：US12006542B2
公开(公告)日：2024-06-11
申请号：US16620571
申请日：2018-06-11
Applicant: University of Houston System
Inventor： Shoujun Xu , Qiongzheng Hu , Yuhong Wang
IPC: C12Q1/6811 , B01L3/00 , B01L7/00 , C12Q1/6816 , C12Q1/6874 , C12Q1/6806 , C12Q1/6818
CPC classification number: C12Q1/6874 , B01L3/502761 , B01L7/52 , B01L2200/0663 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/18 , B01L2400/0439 , C12Q1/6806 , C12Q1/6818
Abstract: Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.
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公开(公告)号：US09778249B2
公开(公告)日：2017-10-03
申请号：US15514683
申请日：2015-09-25
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： Shoujun Xu , Qiongzheng Hu , Yuhong Wang , Te-Wei Tsai
IPC: G01N33/553 , C12Q1/68 , G01N33/53
CPC classification number: G01N33/5308 , C12Q1/6804 , G01N33/54333 , G01N2500/04 , G01N2500/20
Abstract: Methods of quantifying the efficiency of a drug molecule for its targeted receptor, using a differential binding force to quantify the efficiency of a drug molecule to its targeted receptor.
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Patent Agency Ranking
3.发明授权公开(公告)号：US12085534B2
公开(公告)日：2024-09-10
申请号：US16968535
申请日：2019-02-06
Applicant: University of Houston System
Inventor： Shoujun Xu , Yuhong Wang , Haina Jia , Heng Yin , Yujia Mao
CPC classification number: G01N27/72 , B06B1/0207 , B06B1/0622 , B06B1/0651 , G01N33/15 , B06B2201/77
Abstract: A method of measuring dissociation of the biomolecular bonds in one or multiple sample wells using super-resolution force spectroscopy (SURFS). SURFS utilizes precise ultrasound radiation to exert an acoustic radiation force on the biomolecular bonds labeled with magnetic particles. The force-induced dissociation of the protein bonds labeled with magnetic particles may be measured as a reduced magnetic signal by a magnetic sensor. The force resolution allows for differentiating biomolecular bonds with an extremely high level of precision. The biomolecular bonds include protein-protein, protein-nucleic acid, nucleic acid-nucleic acid, small molecule-protein, and small molecule-nucleic acid interactions.
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公开(公告)号：US20240084356A1
公开(公告)日：2024-03-14
申请号：US18272535
申请日：2021-12-22
Applicant: UNIVERSITY OF HOUSTON SYSTEM
Inventor： Yuhong Wang , Doris Xu
IPC: C12P21/02 , C12N9/00 , C12N9/10 , C12N15/113
CPC classification number: C12P21/02 , C12N9/104 , C12N9/93 , C12N15/113 , C12Y203/02012 , C12Y601/01 , C12N2310/12
Abstract: Embodiments of the present disclosure pertain to methods of synthesizing a peptide by associating at least one isolated ribosomal RNA (rRNA) fragment with a plurality of transfer RNA fragments linked to amino acids (tRNA fragments). The at least one rRNA fragment includes at least one domain that associates with the tRNA fragments. The at least one rRNA fragment catalyzes the synthesis of the peptide through peptidyl transfer of the amino acids from the tRNA fragments independently of messenger RNA (mRNA) templates. Additionally, the peptidyl transfer occurs independently of proteins. Further embodiments of the present disclosure pertain to systems for synthesizing a peptide. Such systems include the rRNA fragments of the present disclosure and optionally a plurality of tRNA fragments.
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5.发明申请公开(公告)号：US20210041395A1
公开(公告)日：2021-02-11
申请号：US16968535
申请日：2018-02-08
Applicant: University of Houston System
Inventor： Shoujun Xu , Yuhong Wang , Haina Jia , Heng Yin , Yujia Mao
Abstract: A method of measuring dissociation of the biomolecular bonds in one or multiple sample wells using super-resolution force spectroscopy (SURFS). SURFS utilizes precise ultrasound radiation to exert an acoustic radiation force on the biomolecular bonds labeled with magnetic particles. The force-induced dissociation of the protein bonds labeled with magnetic particles may be measured as a reduced magnetic signal by a magnetic sensor. The force resolution allows for differentiating biomolecular bonds with an extremely high level of precision. The biomolecular bonds include protein-protein, protein-nucleic acid, nucleic acid-nucleic acid, small molecule-protein, and small molecule-nucleic acid interactions.
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公开(公告)号：US20240287603A1
公开(公告)日：2024-08-29
申请号：US18653029
申请日：2024-05-02
Applicant: University of Houston system
Inventor： Shoujun Xu , Qiongzheng Hu , Yuhong Wang
IPC: C12Q1/6874 , B01L3/00 , B01L7/00 , C12Q1/6806 , C12Q1/6818
CPC classification number: C12Q1/6874 , B01L3/502761 , B01L7/52 , B01L2200/0663 , B01L2300/044 , B01L2300/0654 , B01L2300/0672 , B01L2300/18 , B01L2400/0439 , C12Q1/6806 , C12Q1/6818
Abstract: Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.
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公开(公告)号：US20230160003A1
公开(公告)日：2023-05-25
申请号：US16620571
申请日：2018-06-11
Applicant: University of Houston System
Inventor： Shoujun Xu , Qiongzheng Hu , Yuhong Wang
IPC: C12Q1/6874 , B01L3/00 , B01L7/00
CPC classification number: C12Q1/6874 , B01L3/502761 , B01L7/52 , C12Q1/6806
Abstract: Embodiments of the present disclosure pertain to methods of utilizing force-modulated hybridization to determine the length of an analyte strand, to determine an unknown nucleic acid sequence, or to determine the binding of a nucleotide to an active agent. Additional embodiments of the present disclosure pertain to sample holder devices and methods of utilizing such devices. Further embodiments of the present disclosure pertain to detection devices.
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