公开(公告)号：WO2014120808A8

公开(公告)日：2015-09-11

申请号：PCT/US2014013652

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: C07D213/75 ,  A61K31/44 ,  A61P29/00 ,  C07D401/12

CPC classification number: C07D213/75 ,  A61K31/4412 ,  C07D401/12 ,  C07D405/12

Abstract: The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract translation: 本发明涉及用作钠通道抑制剂的式I和I'或其药学上可接受的盐的吡啶酮酰胺化合物：本发明还提供了包含本发明化合物的药学上可接受的组合物和使用该组合物的方法 用于治疗各种疾病，包括疼痛。

公开(公告)号：WO2014120815A1

公开(公告)日：2014-08-07

申请号：PCT/US2014013662

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: C07D403/12 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/498 ,  A61P25/00 ,  A61P29/00 ,  C07D215/54 ,  C07D241/44 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D215/54 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  C07D241/44 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: formula (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract translation: 本发明涉及可用作钠通道抑制剂的式（I）化合物或其药学上可接受的盐：式（I）。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括疼痛）的方法。

公开(公告)号：CA2898653C

公开(公告)日：2021-09-28

申请号：CA2898653

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: C07D213/79 ,  A61K31/44 ,  A61P29/00 ,  C07C235/64

Abstract: The invention relates to amide compounds of formulae I and I': and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

公开(公告)号：RS61503B1

公开(公告)日：2021-03-31

申请号：RSP20210235

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: C07D213/75 ,  A61K31/44 ,  A61K31/4412 ,  A61P29/00 ,  C07D401/12 ,  C07D405/12

公开(公告)号：PH12020500066A1

公开(公告)日：2020-09-28

申请号：PH12020500066

申请日：2020-01-08

Applicant: VERTEX PHARMA

Inventor： AHMAD NADIA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  CAMP JOANNE LOUISE ,  FANNING LEV TYLER DEWEY ,  HADIDA RUAH SARA SABINA ,  HURLEY DENNIS ,  SCHMIDT YVONNE ,  SHAW DAVID ,  PATEL URVI ,  THOMSON STEPHEN ANDREW ,  MEIRELES LIDIO MARX CARVALHO

IPC: C07C237/42 ,  A61K31/165 ,  A61P29/02 ,  C07D213/81 ,  C07D213/82

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

公开(公告)号：MA49566A

公开(公告)日：2020-05-20

申请号：MA49566

申请日：2018-07-11

Applicant: VERTEX PHARMA

Inventor： AHMAD NADIA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  CAMP JOANNE LOUISE ,  FANNING LEV TYLER DEWEY ,  HADIDA RUAH SARA SABINA ,  HURLEY DENNIS ,  MEIRELES LIDIO MARX CARVALHO ,  PATEL URVI ,  SCHMIDT YVONNE ,  SHAW DAVID ,  THOMSON STEPHEN ANDREW

IPC: A61K31/165 ,  A61P29/02 ,  C07C237/42 ,  C07D213/81 ,  C07D213/82

公开(公告)号：HUE033370T2

公开(公告)日：2017-11-28

申请号：HUE14704053

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: A61K31/44 ,  A61P29/00

公开(公告)号：SG10201706206PA

公开(公告)日：2017-08-30

申请号：SG10201706206P

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

Abstract: The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels:The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

公开(公告)号：PE20151781A1

公开(公告)日：2015-12-02

申请号：PE2015001572

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JR JAMES PHILIP

IPC: C07D213/75 ,  A61K31/44 ,  A61P29/00 ,  C07D401/12

Abstract: La invencion se refiere a compuestos de piridonamida de la formula l y I' o sus sales farmaceuticamente aceptables, que G es X-Rx, X es enlace o alquilo C1-C6; RX es H; R1 es H, halogeno; R2 es CN, H; R3 es alquilo C1-C6 ; R4 es H, halogeno; R8 y R9 son halogeno o alquilo C1-C6; p es 0-3. Son utiles como inhibidores de los canales de sodio. Tambien se refiere a una composiciones farmaceuticamente.

公开(公告)号：CA2898653A1

公开(公告)日：2014-08-07

申请号：CA2898653

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP JR

IPC: C07D213/79 ,  A61K31/44 ,  A61P29/00 ,  C07C235/64

Abstract: The invention relates to amide compounds of formula I and For pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I), (I') The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.