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公开(公告)号：WO2007076070A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049141
申请日：2006-12-22
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
CPC classification number: A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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2.发明申请HETEROARYLAMINOSULFONYLPHENYL DERIVATIVES FOR USE AS SODIUM OR CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN 审中-公开用于治疗疼痛的钠或钙通道阻断剂的异喹啉基苯基衍生物
公开(公告)号：WO2005013914A8
公开(公告)日：2006-09-28
申请号：PCT/US2004025827
申请日：2004-08-09
Applicant: VERTEX PHARMA , GONZALES JESUS E III , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
Inventor： GONZALES JESUS E III , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
IPC: C07C311/46 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
CPC classification number: C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
Abstract translation: 本发明涉及电压门控钠通道抑制剂的式（I-A）化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病如疼痛的方法。
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公开(公告)号：WO2014120820A1
公开(公告)日：2014-08-07
申请号：PCT/US2014013667
申请日：2014-01-29
Applicant: VERTEX PHARMA
Inventor： HADIDA-RUAH SARA SABINA , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , ASGIAN LULIANA LUCI , BEAR BRIAN RICHARD , TERMIN ANDREAS P , JOHNSON JAMES PHILIP
IPC: C07D213/79 , A61K31/44 , A61P29/00 , C07C235/64
CPC classification number: A61K31/44 , A61K31/192 , C07C235/64 , C07D213/79
Abstract: The invention relates to amide compounds of formula I and For pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I), (I') The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
Abstract translation: 本发明涉及式I的酰胺化合物及其药学上可接受的盐，其可用作钠通道的抑制剂：（I），（I'）本发明还提供包含本发明化合物的药学上可接受的组合物和使用组合物的方法 治疗各种疾病，包括疼痛。
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公开(公告)号：WO2006122014A3
公开(公告)日：2006-12-28
申请号：PCT/US2006017699
申请日：2006-05-08
Applicant: VERTEX PHARMA , KAWATKAR AARTI S , WHITNEY TARA , NEUBERT TIMOTHY D , ZIMMERMANN NICOLE , TERMIN ANDREAS P , MARTINBOROUGH ESTHER
Inventor： KAWATKAR AARTI S , WHITNEY TARA , NEUBERT TIMOTHY D , ZIMMERMANN NICOLE , TERMIN ANDREAS P , MARTINBOROUGH ESTHER
IPC: C07D417/12 , A61K31/404 , A61K31/4709 , A61K31/4725 , A61P23/00 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14
CPC classification number: C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
Abstract: Bicyclic derivatives having formula (I) wherein Z, R N , B,q,Q and R Q are as defined in claim 1 and a composition thereof are useful as ion channel antagonists:
Abstract translation: 具有式（I）的双环衍生物，其中Z，R N，B，q，Q和R Q如权利要求1所定义，其组合物可用作离子通道 拮抗剂：
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公开(公告)号：WO2006023852A3
公开(公告)日：2006-08-31
申请号：PCT/US2005029780
申请日：2005-08-19
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
IPC: A61K31/435 , A61K31/438 , A61P25/00 , A61P43/00 , C07D471/00
CPC classification number: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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Patent Agency Ranking
公开(公告)号：WO2014120808A8
公开(公告)日：2015-09-11
申请号：PCT/US2014013652
申请日：2014-01-29
Applicant: VERTEX PHARMA
Inventor： HADIDA-RUAH SARA SABINA , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , ASGIAN IULIANA LUCI , BEAR BRIAN RICHARD , TERMIN ANDREAS P , JOHNSON JAMES PHILIP
IPC: C07D213/75 , A61K31/44 , A61P29/00 , C07D401/12
CPC classification number: C07D213/75 , A61K31/4412 , C07D401/12 , C07D405/12
Abstract: The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
Abstract translation: 本发明涉及用作钠通道抑制剂的式I和I'或其药学上可接受的盐的吡啶酮酰胺化合物：本发明还提供了包含本发明化合物的药学上可接受的组合物和使用该组合物的方法 用于治疗各种疾病，包括疼痛。
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公开(公告)号：WO2014120815A1
公开(公告)日：2014-08-07
申请号：PCT/US2014013662
申请日：2014-01-29
Applicant: VERTEX PHARMA
Inventor： HADIDA-RUAH SARA SABINA , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , ASGIAN IULIANA LUCI , BEAR BRIAN RICHARD , TERMIN ANDREAS P , JOHNSON JAMES PHILIP
IPC: C07D403/12 , A61K31/465 , A61K31/4709 , A61K31/498 , A61P25/00 , A61P29/00 , C07D215/54 , C07D241/44 , C07D401/12 , C07D413/12 , C07D417/12
CPC classification number: C07D215/54 , A61K31/47 , A61K31/4709 , A61K31/498 , C07D241/44 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
Abstract: The invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: formula (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
Abstract translation: 本发明涉及可用作钠通道抑制剂的式（I）化合物或其药学上可接受的盐：式（I）。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括疼痛）的方法。
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公开(公告)号：WO2006130493A8
公开(公告)日：2008-02-21
申请号：PCT/US2006020521
申请日：2006-05-26
Applicant: VERTEX PHARMA , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D , KRENITSKY PAUL , JOSHI PRAMOD
Inventor： WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D , KRENITSKY PAUL , JOSHI PRAMOD
IPC: C07D417/04 , A61K31/44 , A61K31/496
CPC classification number: C07D277/38 , C07D285/08 , C07D417/04
Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2006130493A3
公开(公告)日：2007-03-01
申请号：PCT/US2006020521
申请日：2006-05-26
Applicant: VERTEX PHARMA , KRENITSKY PAUL , JOSHI PRAMOD , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D
Inventor： KRENITSKY PAUL , JOSHI PRAMOD , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D
IPC: C07D417/04 , A61K31/44 , A61K31/496
CPC classification number: C07D277/38 , C07D285/08 , C07D417/04
Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2006028904A9
公开(公告)日：2006-06-22
申请号：PCT/US2005031146
申请日：2005-08-31
Applicant: VERTEX PHARMA , WILSON DEAN M , TERMIN ANDREAS P , GONZALEZ JESUS E III , FANNING LEV T D , NEUBERT TIMOTHY D , KRENITSKY PAUL , JOSHI PRAMOD , HURLEY DENNIS J , SHETH URVI , BOGER JOSHUA S
Inventor： WILSON DEAN M , TERMIN ANDREAS P , GONZALEZ JESUS E III , FANNING LEV T D , NEUBERT TIMOTHY D , KRENITSKY PAUL , JOSHI PRAMOD , HURLEY DENNIS J , SHETH URVI , BOGER JOSHUA S
IPC: C07D239/94 , A61K31/498 , A61P9/06 , A61P25/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14
CPC classification number: C07D401/04 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及用作电压门控钠通道抑制剂的化合物。 本发明还提供了包含本发明化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病的方法。
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