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公开(公告)号：EP1178797A4
公开(公告)日：2003-05-02
申请号：EP00916479
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34
CPC classification number: C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
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公开(公告)号：PL211562B1
公开(公告)日：2012-05-31
申请号：PL35091100
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D263/32 , C07D307/20 , A61K31/27 , A61K31/275 , A61K31/277 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07C275/34 , C07C275/40 , C07C275/42 , C07D413/12 , C07D417/12 , C07F9/653
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公开(公告)号：CZ20013349A3
公开(公告)日：2002-03-13
申请号：CZ20013349
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , C07F9/143 , C07C275/30 , C07C275/34 , A61K31/17 , A61P31/00
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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公开(公告)号：NO20014535A
公开(公告)日：2001-11-19
申请号：NO20014535
申请日：2001-09-18
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL C , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653
CPC classification number: C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
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公开(公告)号：PL350911A1
公开(公告)日：2003-02-10
申请号：PL35091100
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , C07C275/34
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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Patent Agency Ranking
公开(公告)号：HU0201214A2
公开(公告)日：2002-08-28
申请号：HU0201214
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： BADIA MICHAEL C , BETHIEL SCOTT , SAUNDERS JEFFREY , STAMOS DEAN , TRUDEAU MARTIN
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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公开(公告)号：BR0009167A
公开(公告)日：2001-12-26
申请号：BR0009167
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS EFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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公开(公告)号：CA2367017A1
公开(公告)日：2000-09-28
申请号：CA2367017
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： BADIA MICHAEL , SAUNDERS JEFFREY , TRUDEAU MARTIN , STAMOS DEAN , BETHIEL SCOTT
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34
Abstract: The present invention relates to compounds which inhibit IMPDH. This inventi on also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：CZ301802B6
公开(公告)日：2010-06-30
申请号：CZ20013349
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07C275/34 , C07D307/20 , A61K31/17 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653
Abstract: Rešení se týká derivátu mocoviny vzorce 181 a 169, které inhibují IMPDH, a farmaceutických prostredku, které je obsahují. Používají se jako terapeutická cinidla pro procesy zprostredkovávané IMPDH, napríklad pri odmítání transplantátu, reakci štepu vuci hostiteli nebo autoimunitním onemocnení.
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公开(公告)号：NO321932B1
公开(公告)日：2006-07-24
申请号：NO20014535
申请日：2001-09-18
Applicant: VERTEX PHARMA
Inventor： SAUNDERS JEFFREY O , BADIA MICHAEL C , STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT
IPC: C07D263/32 , C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D413/12 , C07D417/12 , C07F9/653
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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