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公开(公告)号：WO2005123076A3
公开(公告)日：2006-06-15
申请号：PCT/US2005019929
申请日：2005-06-08
Applicant: VERTEX PHARMA , MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
CPC classification number: A61K38/07 , A61K9/145 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K31/497 , A61K45/06
Abstract: Forms and formulations of VX-950 and uses thereof.
Abstract translation: VX-950的形式和配方及其用途。
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公开(公告)号：EP1765283A4
公开(公告)日：2012-11-28
申请号：EP05757623
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG , PANICUCCI RICCARDO N
IPC: A61K9/14 , A61K9/10 , A61K31/454 , A61K31/497 , A61K45/06 , A61K47/38
CPC classification number: A61K38/07 , A61K9/145 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K31/497 , A61K45/06
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公开(公告)号：SG153800A1
公开(公告)日：2009-07-29
申请号：SG2009038597
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
IPC: A61K9/14 , A61K31/454 , A61K45/06
Abstract: Forms and formulations of VX-950 and uses thereof.
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公开(公告)号：AR049297A1
公开(公告)日：2006-07-12
申请号：ARP050102345
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： CUI YONG , MURPHY MAURA , CONNELLY PATRICK , HURTER PATRICIA , DINEHART KIRK
IPC: A61K9/14 , A61K31/454 , A61K45/06 , A61K31/497 , A61K9/00 , A61K9/10 , A61K47/38 , A61K47/20 , A61K47/22 , A61P31/12
Abstract: Una composicion farmacéutica para el tratamiento de la infeccion de la hepatitis C. Reivindicacion 1: Una preparacion purificada de VX-950 amorfo. Reivindicacion 25: Una composicion farmacéutica que comprende un VX-950 amorfo como una dispersion solida y uno o más de un surfactante, polímero de soporte, sustancia inerte farmacéuticamente aceptable o portador farmacéuticamente aceptable. Reivindicacion 29: La composicion farmacéutica de la reivindicacion 25, donde el polímero de soporte es HPMC. Reivindicacion 30: La composicion farmacéutica de la reivindiacion 25, donde el polímero de soporte es HPMCAS. Reivindicacion 34: La composicion farmacéutica de la reivindicacion 31, donde el surfactante es lauril sulfato de sodio o Vitamina E TPGS.
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公开(公告)号：CA2560818A1
公开(公告)日：2005-10-13
申请号：CA2560818
申请日：2005-03-22
Applicant: VERTEX PHARMA
Inventor： NYCE PHILIP L , BLYTHE TODD A , CUI YONG
IPC: C07C275/40 , A61K31/17 , A61K31/325 , A61P37/06 , C07C255/51 , C07C273/18 , C07C275/42
Abstract: The present invention relates to polymorphic forms of (1-{3-[3-(4-cyano-3- methoxy-phenyl)ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester, processes therein, pharmaceutical compositions thereof, and uses therewith.
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Patent Agency Ranking
公开(公告)号：CA2569310A1
公开(公告)日：2005-12-29
申请号：CA2569310
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , CUI YONG , CONNELLY PATRICK , MURPHY MAURA , DINEHART KIRK
Abstract: Forms and formulations of VX-950 and uses thereof.
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公开(公告)号：BRPI0511900A
公开(公告)日：2008-01-22
申请号：BRPI0511900
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
Abstract: Forms and formulations of VX-950 and uses thereof.
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公开(公告)号：AU2005253957A1
公开(公告)日：2005-12-29
申请号：AU2005253957
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , CUI YONG , DINEHART KIRK , CONNELLY PATRICK , MURPHY MAURA
Abstract: Forms and formulations of VX-950 and uses thereof.
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公开(公告)号：NZ588471A
公开(公告)日：2012-02-24
申请号：NZ58847105
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
IPC: A01N43/40 , A61K9/14 , A61K9/48 , A61K31/454 , A61K45/06
Abstract: Disclosed herein are solid dispersion comprising VX-950 (telaprevir) and a polymer, particularly hydroxyproplymethylcellulose (HPMC) or hydroxypropylmethylcellulose acetate succinate (HPMCAS), wherein the solid dispersion is obtained by spray drying and a polymer is present in an amount from about 10% by weight to about 80% by weight. Said forms and formulations disclosed herein have improved bioavailability relative to crystalline VX-950 and are useful for treating HCV infection.
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公开(公告)号：ZA200802676B
公开(公告)日：2009-12-30
申请号：ZA200802676
申请日：2008-03-26
Applicant: VERTEX PHARMA
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG , PANICUCCI RICCARDO N
IPC: A61K20100101 , A61K9/14 , A61K31/454 , A61K45/06
Abstract: Forms and formulations of VX-950 and uses thereof.
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