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1.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体形式
公开(公告)号：WO2007079139A9
公开(公告)日：2007-11-29
申请号：PCT/US2006049421
申请日：2006-12-28
Applicant: VERTEX PHARMA , HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
Inventor： HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
IPC: A01N43/40 , A61K31/445
CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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公开(公告)号：WO2005123076A3
公开(公告)日：2006-06-15
申请号：PCT/US2005019929
申请日：2005-06-08
Applicant: VERTEX PHARMA , MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
CPC classification number: A61K38/07 , A61K9/145 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K31/497 , A61K45/06
Abstract: Forms and formulations of VX-950 and uses thereof.
Abstract translation: VX-950的形式和配方及其用途。
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公开(公告)号：EP1765283A4
公开(公告)日：2012-11-28
申请号：EP05757623
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG , PANICUCCI RICCARDO N
IPC: A61K9/14 , A61K9/10 , A61K31/454 , A61K31/497 , A61K45/06 , A61K47/38
CPC classification number: A61K38/07 , A61K9/145 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K31/497 , A61K45/06
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4.发明公开SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权FESTE FORMEN VON N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧杂环辛烷-3-羧酸
公开(公告)号：EP1993360A4
公开(公告)日：2010-12-01
申请号：EP06848237
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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公开(公告)号：ME03786B
公开(公告)日：2021-04-20
申请号：MEP202088
申请日：2020-12-29
Applicant: VERTEX PHARMA
Inventor： KRAWIEC MARIUSZ , ROWE WILLIAM , HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , COSTACHE ADRIANA , FENG YUSHI , TRUDEAU MARTIN
IPC: A61K31/445 , C07D215/56
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Patent Agency Ranking6.发明专利
公开(公告)号：CY1118980T1
公开(公告)日：2018-01-10
申请号：CY171100490
申请日：2017-05-05
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
Abstract: ΗπαρούσαεφεύρεσηαφοράσεστερεάςκατάστασηςμορφέςτουΝ-[2,4-δις(1,1-διμεθυλαιθυλ)-5-υδροξυφαινυλ]-1,4-διυδρο-4-οξοκινολινο-3-καρβοξαμιδίου (Ένωση 1), φαρμακευτικέςσυνθέσειςαυτούκαιμεθόδουςμεαυτό.
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公开(公告)号：SG153800A1
公开(公告)日：2009-07-29
申请号：SG2009038597
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
IPC: A61K9/14 , A61K31/454 , A61K45/06
Abstract: Forms and formulations of VX-950 and uses thereof.
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公开(公告)号：AR049297A1
公开(公告)日：2006-07-12
申请号：ARP050102345
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： CUI YONG , MURPHY MAURA , CONNELLY PATRICK , HURTER PATRICIA , DINEHART KIRK
IPC: A61K9/14 , A61K31/454 , A61K45/06 , A61K31/497 , A61K9/00 , A61K9/10 , A61K47/38 , A61K47/20 , A61K47/22 , A61P31/12
Abstract: Una composicion farmacéutica para el tratamiento de la infeccion de la hepatitis C. Reivindicacion 1: Una preparacion purificada de VX-950 amorfo. Reivindicacion 25: Una composicion farmacéutica que comprende un VX-950 amorfo como una dispersion solida y uno o más de un surfactante, polímero de soporte, sustancia inerte farmacéuticamente aceptable o portador farmacéuticamente aceptable. Reivindicacion 29: La composicion farmacéutica de la reivindicacion 25, donde el polímero de soporte es HPMC. Reivindicacion 30: La composicion farmacéutica de la reivindiacion 25, donde el polímero de soporte es HPMCAS. Reivindicacion 34: La composicion farmacéutica de la reivindicacion 31, donde el surfactante es lauril sulfato de sodio o Vitamina E TPGS.
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公开(公告)号：HUE049976T2
公开(公告)日：2020-11-30
申请号：HUE17154944
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
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公开(公告)号：ES2790700T3
公开(公告)日：2020-10-28
申请号：ES17154944
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
Abstract: Una composición farmacéutica que comprende N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida amorfa; en la que N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida amorfa tiene menos del 30 % de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida cristalina.
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