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1.发明申请PHARMACEUTICAL COMPOSITION OF N- [2,4-BIS (1, 1 -DIMETHYLETHYL) - 5 - HYDROXYPHENYL] - 1, 4 - DIHYDRO - 4 - OXOQUINOLINE - 3 - CARBOXAMIDE AND ADMINISTRATION THEREOF 审中-公开N- [2,4-BIS（1,1-二甲基）-5-羟基苯基] -1,4-二氢-4-氧杂喹啉-3-羧酰胺的药物组合物及其施用方法
公开(公告)号：WO2010019239A3
公开(公告)日：2011-05-26
申请号：PCT/US2009004629
申请日：2009-08-13
Applicant: VERTEX PHARMA , ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K47/32
CPC classification number: A61K9/1652 , A61K9/1635 , A61K9/2054 , A61K9/282 , A61K31/47
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- 3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
Abstract translation: 本发明涉及包含N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法 本发明的药物组合物和本发明的药物组合物的给药方法。
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2.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体形式
公开(公告)号：WO2007079139A9
公开(公告)日：2007-11-29
申请号：PCT/US2006049421
申请日：2006-12-28
Applicant: VERTEX PHARMA , HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
Inventor： HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
IPC: A01N43/40 , A61K31/445
CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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公开(公告)号：WO2005123076A3
公开(公告)日：2006-06-15
申请号：PCT/US2005019929
申请日：2005-06-08
Applicant: VERTEX PHARMA , MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG
CPC classification number: A61K38/07 , A61K9/145 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K31/497 , A61K45/06
Abstract: Forms and formulations of VX-950 and uses thereof.
Abstract translation: VX-950的形式和配方及其用途。
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公开(公告)号：WO2007142951A2
公开(公告)日：2007-12-13
申请号：PCT/US2007012715
申请日：2007-05-30
Applicant: VERTEX PHARMA , KADIYALA IRINA NIKOLAEVNA , LIN WU , HURTER PATRICIA
Inventor： KADIYALA IRINA NIKOLAEVNA , LIN WU , HURTER PATRICIA
CPC classification number: A61K9/1688 , A61K9/2077 , A61K9/2095 , A61K31/401
Abstract: The invention relates to a controlled release formulation for an oral cytokine inhibitor of interleukin-1 beta converting enzyme.
Abstract translation: 本发明涉及一种用于白细胞介素-1β转换酶的口服细胞因子抑制剂的控释制剂。
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5.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式
公开(公告)号：WO2007079139A2
公开(公告)日：2007-07-12
申请号：PCT/US2006049421
申请日：2006-12-28
Applicant: VERTEX PHARMA , HURTER PATRICIA
Inventor： HURTER PATRICIA
IPC: A61K31/4704
CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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Patent Agency Ranking
公开(公告)号：EP1765283A4
公开(公告)日：2012-11-28
申请号：EP05757623
申请日：2005-06-08
Applicant: VERTEX PHARMA
Inventor： MURPHY MAURA , DINEHART KIRK , HURTER PATRICIA , CONNELLY PATRICK , CUI YONG , PANICUCCI RICCARDO N
IPC: A61K9/14 , A61K9/10 , A61K31/454 , A61K31/497 , A61K45/06 , A61K47/38
CPC classification number: A61K38/07 , A61K9/145 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K31/497 , A61K45/06
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7.发明公开SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权FESTE FORMEN VON N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧杂环辛烷-3-羧酸
公开(公告)号：EP1993360A4
公开(公告)日：2010-12-01
申请号：EP06848237
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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公开(公告)号：MX373230B
公开(公告)日：2025-03-05
申请号：MX2018015847
申请日：2011-02-14
Applicant: VERTEX PHARMA
Inventor： GROSSI ALFREDO , YOUNG CHRISTOPHER , DINEHART KIRK , OVERHOFF KIRK , JACOBUS VERWIJS MARINUS , BOTFIELD MARTYN , HURTER PATRICIA , GROOTENHUIS PETER D J , ROWE WILLIAM
Abstract: La presente invención se refiere a composiciones farmacéuticas que comprenden una dispersión sólida de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida, a métodos de producción de composiciones farmacéuticas de la presente invención y a métodos de administración de composiciones farmacéuticas de la presente invención.
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公开(公告)号：SI2464337T2
公开(公告)日：2024-08-30
申请号：SI201031871
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：FI2464337T4
公开(公告)日：2024-07-18
申请号：FI10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS , OVERHOFF KIRK , GROOTENHUIS PETER , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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