公开(公告)号：AU2007235237B2

公开(公告)日：2011-08-18

申请号：AU2007235237

申请日：2007-04-11

Applicant: VERTEX PHARMA

Inventor： JUAN-MIGUEL JIMENEZ ,  DANIEL ROBINSON ,  PHILIP COLLIER ,  RONALD KNEGTEL

IPC: C07D231/14 ,  A61K31/426 ,  A61P35/00 ,  C07D233/90 ,  C07D277/56

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.

公开(公告)号：ZA200704888B

公开(公告)日：2009-02-25

申请号：ZA200704888

申请日：2005-11-22

Applicant: VERTEX PHARMA

Inventor： HALEY BINCH ,  DANIEL ROBINSON ,  ANDREW MILLER ,  DAMIEN FRAYSSE

IPC: A61K20090101 ,  C07D20090101

Abstract: The present invention relates to compounds of formula (I): wherein x, R1, R2 and R3 denote as in Claim 1, useful as inhibitors of Aurora protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides process for preparing compounds of the invention.

公开(公告)号：BRPI0509369B1

公开(公告)日：2021-08-03

申请号：BRPI0509369

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： ALBERT PIERCE ,  ALEX ARONOV ,  DAMIEN FRAYSSE ,  DANIEL ROBINSON ,  DAVID LAUFFER ,  DEAN BOYALL ,  EDMUND HARRINGTON ,  FRANCESCO G SALITURO ,  FRANÇOISE PIERARD ,  HAYLEY BINCH ,  JEAN-DAMIEN CHARRIER ,  JEREMY GREEN ,  JIAN WANG ,  JOANNE PINDER ,  JON COME ,  LUC FARMER ,  MICHAEL MORTIMORE ,  RANDY BETHIEL ,  SIMON EVERITT ,  TIANSHENG WANG

IPC: C07D471/04 ,  C07D519/00

Abstract: compostos azaindóis úteis como lnibidores de jak e outras proteína cinases e suas composições farmacêuticas. a presente invenção refere-se a compostos da fórmula (i), (i) os quais são inibidores de proteína cinases. a invenção também provê composições farmacêuticas compreendendo os compostos da invenção e métodos de uso das composições no tratamento de vários distúrbios.

公开(公告)号：ZA200800992B

公开(公告)日：2009-09-30

申请号：ZA200800992

申请日：2006-07-21

Applicant: VERTEX PHARMA

Inventor： SIMON EVERITT ,  BINCH HAYLEY ,  MICHAEL MORTIMORE ,  DANIEL ROBINSON ,  DEAN STAMOS

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to compounds useful as inhibitors of Aurora, FLT-3, or PDK1 protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the invention.