公开(公告)号：AU2010254053A1

公开(公告)日：2011-12-01

申请号：AU2010254053

申请日：2010-05-27

Applicant: VERTEX PHARMA

Inventor： PAN LI ,  NATHAN WAAL ,  STEVEN RONKIN ,  QING TANG ,  DAVID LAUFFER

IPC: C07D513/04 ,  A61K31/433 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula (I) and methods of using the compositions in the treatment of proliferative disorders.

公开(公告)号：ZA200804681B

公开(公告)日：2009-11-25

申请号：ZA200804681

申请日：2006-11-30

Applicant: VERTEX PHARMA INC

Inventor： DAVID LAUFFER ,  ALEXANDER ARONOV ,  PAN LI ,  DAVID DEININGER ,  KIRA MCGINTY ,  DEAN STAMOS ,  JON COME ,  MICHELLE STEWART

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

公开(公告)号：AU2006320580B2

公开(公告)日：2011-06-23

申请号：AU2006320580

申请日：2006-11-30

Applicant: VERTEX PHARMA

Inventor： MICHELLE STEWART ,  ALEXANDER ARONOV ,  PAN LI ,  DAVID DEININGER ,  DAVID LAUFFER ,  DEAN STAMOS ,  KIRA MCGINTY ,  JON COME

IPC: C07D487/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.

公开(公告)号：ZA200802685B

公开(公告)日：2009-10-28

申请号：ZA200802685

申请日：2006-09-28

Applicant: VERTEX PHARMA

Inventor： FRANCESCO SALITURO ,  LUC FARMER ,  TIANSHENG WANG ,  JIAN WANG ,  RANDY BETHIEL ,  MARION WANNAMAKER ,  GABRIEL MARTINEZ-BOTELLA ,  JOHN DUFFY ,  ALEXANDER ARONOV ,  DAVID LAUFFER ,  ALBERT PIERCE

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorder.

公开(公告)号：BRPI0509369B1

公开(公告)日：2021-08-03

申请号：BRPI0509369

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： ALBERT PIERCE ,  ALEX ARONOV ,  DAMIEN FRAYSSE ,  DANIEL ROBINSON ,  DAVID LAUFFER ,  DEAN BOYALL ,  EDMUND HARRINGTON ,  FRANCESCO G SALITURO ,  FRANÇOISE PIERARD ,  HAYLEY BINCH ,  JEAN-DAMIEN CHARRIER ,  JEREMY GREEN ,  JIAN WANG ,  JOANNE PINDER ,  JON COME ,  LUC FARMER ,  MICHAEL MORTIMORE ,  RANDY BETHIEL ,  SIMON EVERITT ,  TIANSHENG WANG

IPC: C07D471/04 ,  C07D519/00

Abstract: compostos azaindóis úteis como lnibidores de jak e outras proteína cinases e suas composições farmacêuticas. a presente invenção refere-se a compostos da fórmula (i), (i) os quais são inibidores de proteína cinases. a invenção também provê composições farmacêuticas compreendendo os compostos da invenção e métodos de uso das composições no tratamento de vários distúrbios.

公开(公告)号：AU2010254055A1

公开(公告)日：2011-12-15

申请号：AU2010254055

申请日：2010-05-27

Applicant: VERTEX PHARMA

Inventor： DAVID LAUFFER ,  PAN LI ,  KIRA MCGINTY

IPC: C07D513/04 ,  A61K31/47 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula (I) and methods of using the compositions in the treatment of proliferative disorders.

公开(公告)号：AU2010254063A1

公开(公告)日：2011-12-01

申请号：AU2010254063

申请日：2010-05-27

Applicant: VERTEX PHARMA

Inventor： DAVID LAUFFER ,  PAN LI

IPC: C07D513/04 ,  A61K31/47 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I), which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.

公开(公告)号：MX2008007049A

公开(公告)日：2008-10-23

申请号：MX2008007049

申请日：2006-11-30

Applicant: VERTEX PHARMA

Inventor： DAVID LAUFFER ,  ALEXANDER ARONOV ,  LI PAN ,  DAVID DEININGER ,  KIRA MCGINTY ,  DEAN STAMOS ,  JON COME ,  MICHELLE STEWART

IPC: C07D487/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04 ,  C07D519/00

Abstract: La presente invención proporciona compuestos útiles como inhibidores de la tirosina quinasa c-Met. La invención también proporciona las composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y los métodos para utilizar las composiciones en el tratamiento de diversos trastornos proliferativos.