公开(公告)号：CA2794145A1

公开(公告)日：2011-09-29

申请号：CA2794145

申请日：2011-03-24

Applicant: VERTEX PHARMA

Inventor： DAS SANJOY KUMAR ,  BENNANI YOUSSEF L ,  LIU BINGCAN ,  CADILHAC CAROLINE ,  HENDERSON JAMES ,  DENIS REAL ,  POISSON CARL ,  MORRIS MARK A ,  KONG LAVAL CHAN CHUN ,  REDDY JAGADEESWAR T ,  YANNOPOULOS CONSTANTIN ,  GIROUX SIMON ,  VAILLANCOURT LOUIS ,  PEREIRA OSWY Z ,  FALARDEAU GUY ,  MAXWELL JOHN

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/14 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/14 ,  C07D495/04

Abstract: Compounds represented by formula I as described herein or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R1, R2, R2', R3, R3', R4, R4', R5, R5', m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：MX2012010918A

公开(公告)日：2013-01-18

申请号：MX2012010918

申请日：2011-03-24

Applicant: VERTEX PHARMA

Inventor： BENNANI YOUSSEF L ,  DAS SANJOY KUMAR ,  PEREIRA OSWY Z ,  YANNOPOULOS CONSTANTIN ,  KONG LAVAL CHAN CHUN ,  POISSON CARL ,  MAXWELL JOHN ,  CADILHAC CAROLINE ,  LIU BINGCAN ,  DENIS REAL ,  FALARDEAU GUY ,  GIROUX SIMON ,  HENDERSON JAMES ,  MORRIS MARK A ,  REDDY JAGADEESWAR T ,  VAILLANCOURT LOUIS

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/14 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/14 ,  C07D495/04

Abstract: Los compuestos representados por la formula I o sales farmacéuticamente aceptables de estos, en donde A, B, ´B, X, Y, R1, R2, R3, R3, R´3, R4, R4´, R5, m, n,, o p son como se definen en la presente descripción, son útiles para tratar las infecciones virales por flaviviridae.

公开(公告)号：RS52874B

公开(公告)日：2013-12-31

申请号：RSP20130306

申请日：2007-11-15

Applicant: VERTEX PHARMA

Inventor： CHAN CHUN KONG LAVAL ,  KUMAR DAS SANJOY ,  POISSON CARL ,  YANNOPOULOS CONSTANTIN G ,  FALARDEAU GUY ,  VAILLANCOURT LOUIS ,  DENIS REAL

IPC: C07D333/40 ,  A61K31/381 ,  A61P31/12 ,  C07D333/38 ,  C07D409/12

Abstract: The present invention relates to compounds represented by formula IA or pharmaceutically acceptable salts and solvates thereof which are useful for treating flaviviridae viral infections wherein R 1 is C 1-6 alkyl or C 3-6 cycloalkyl; X is M is R 5 is cyclohexyl which is unsubstituted or substituted one or more times by R 13 ; R 6 is or cyclohexyl which is substituted in the 4 position by R 14 ; and Y, R 14a and R 14 are as defined herein.

公开(公告)号：AU2011232331A1

公开(公告)日：2012-10-11

申请号：AU2011232331

申请日：2011-03-24

Applicant: VERTEX PHARMA

Inventor： DAS SANJOY KUMAR ,  BENNANI YOUSSEF L ,  KONG LAVAL CHAN CHUN ,  MAXWELL JOHN ,  REDDY JAGADEESWAR ,  YANNOPOULOS CONSTANTIN ,  LIU BINGCAN ,  CADILHAC CAROLINE ,  GIROUX SIMON ,  HENDERSON JAMES ,  DENIS REAL ,  VAILLANCOURT LOUIS ,  PEREIRA OSWY ,  POISSON CARL ,  FALARDEAU GUY ,  MORRIS MARK

IPC: C07D403/14 ,  A61K31/4184 ,  A61P31/14 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/14 ,  C07D495/04

Abstract: Compounds represented by formula I as described herein or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R, R, R', R, R', R, R', R, R', m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.