公开(公告)号：AU2010226400A1

公开(公告)日：2011-10-06

申请号：AU2010226400

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： JOHN DEMATTEI ,  LOOKER ADAM R ,  BOBBIANNA NEUBERT-LANGILLE ,  MARTIN TRUDEAU ,  STEFANIE ROEPER ,  RYAN MICHAEL P ,  LAO YAP DAHRIKA MILFRED ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  GOOR FREDRICK F VAN ,  BOTFIELD MARTYN C ,  GREGOR ZLOKARNIK

IPC: C07D215/233

Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.