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公开(公告)号：AU2010226400A1
公开(公告)日：2011-10-06
申请号：AU2010226400
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： JOHN DEMATTEI , LOOKER ADAM R , BOBBIANNA NEUBERT-LANGILLE , MARTIN TRUDEAU , STEFANIE ROEPER , RYAN MICHAEL P , LAO YAP DAHRIKA MILFRED , KRUEGER BRIAN R , GROOTENHUIS PETER D J , GOOR FREDRICK F VAN , BOTFIELD MARTYN C , GREGOR ZLOKARNIK
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.
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公开(公告)号：BR112021006392A2
公开(公告)日：2021-07-06
申请号：BR112021006392
申请日：2019-10-04
Applicant: VERTEX PHARMA
Inventor： ADAM LOOKER , ALES MEDEK , AMY BETH HALL , BRAD D MAXWELL , CAVAN MCKEON BLIGH , DENNIS JAMES HURLEY , DIANE M BOUCHER , JINWANG XU , JOHN PATRICK MAXWELL , JOSHUA KENNEDY HUSSEY , KEVIN JAMES GAGNON , LEV TYLER DEWEY FANNING , MAC ARTHUR JOHNSON JR , MARY ELIZABETH ECCLES , METTACHIT NAVAMAL , MICHAEL AARON BRODNEY , MICHAEL JOHN BOYD , MICHAEL WALDO , PEDRO M GARCIA BARRANTES , PETER JONES , PHILIPPE MARCEL NUHANT , QING TANG , REBECCA JANE SWETT , ROBERT FRANCIS FIMOGNARI JR , RONALD LEE GREY JR , RUPA SAWANT , SARAH CAROL HOOD , SARATHY KESAVAN , SETU RODAY , SIMON GIROUX , STEFANIE ROEPER , STEPHEN A THOMSON , TIMOTHY LEWIS TAPLEY , UPUL KEERTHI BANDARAGE , VERONIQUE DAMAGNEZ , YI SHI
IPC: C07D471/14 , A61K31/4162 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61P1/16 , A61P11/00 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: moduladores da alfa-1 antitripsina. a presente invenção refere-se a compostos , composições e métodos de uso e preparação dos mesmos, que podem ser úteis para tratar a deficiência de alfa-1 antitripsina (aatd).
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公开(公告)号：BRPI1011506B8
公开(公告)日：2021-05-25
申请号：BRPI1011506
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： ADAM R LOOKER , BOBBIANNA NEUBERT-LANGILLE , BRIAN R KRUEGER , DAHRIKA MILFRED LAO YAP , FREDERICK F VAN GOOR , GREGOR ZLOKARNIK , JOHN DEMATTEI , MARTIN TRUDEAU , MARTYN C BOTFIELD , MICHAEL P RYAN , PETER D J GROOTENHUIS , STEFANIE ROEPER
IPC: C07D215/233
Abstract: processo para a fabricação de moduladores de regulador de condutância de transmembrana de fibrose cística. a presente invenção refere-se a um processo para a preparação de um composto de fórmula 1, compreendendo o acoplamento de um ácido carboxílico de fórmula 2 com uma anilina de fórmula 3 na presença de um agente de acoplamento.
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公开(公告)号：AU2010213628A2
公开(公告)日：2011-09-29
申请号：AU2010213628
申请日：2010-02-12
Applicant: VERTEX PHARMA
Inventor： MICHAEL HURREY , DIMITAR ALARGOV , JOHNSTON STEVEN C , STEFANIE ROEPER , SNOONIAN JOHN R , COWANS BRETT A , PETINKA VLAHOVA , ALEXANDER EBERLIN , MARK EDDLESTON , CHRISTOPHER FRAMPTON
IPC: C07D213/82 , A61K31/4418
Abstract: This invention relates to solid forms of 2-(2, 4-difluorophenyl)-6-(l- (2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith.
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Patent Agency Ranking
公开(公告)号：BRPI1011506B1
公开(公告)日：2020-11-17
申请号：BRPI1011506
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： ADAM R LOOKER , BOBBIANNA NEUBERT-LANGILLE , BRIAN R KRUEGER , DAHRIKA MILFRED LAO YAP , FREDERICK F VAN GOOR , GREGOR ZLOKARNIK , JOHN DEMATTEI , MARTIN TRUDEAU , MARTYN C BOTFIELD , MICHAEL P RYAN , PETER D J GROOTENHUIS , STEFANIE ROEPER
IPC: C07D215/233
Abstract: processo para a fabricação de moduladores de regulador de condutância de transmembrana de fibrose cística. a presente invenção refere-se a um processo para a preparação de um composto de fórmula 1, compreendendo o acoplamento de um ácido carboxílico de fórmula 2 com uma anilina de fórmula 3 na presença de um agente de acoplamento.
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6.发明专利
公开(公告)号：BR112020010335A2
公开(公告)日：2020-11-10
申请号：BR112020010335
申请日：2018-11-30
Applicant: VERTEX PHARMA
Inventor： ADAM LOOKER , ADAM MORGAN , BERENICE LEMERCIER LEWANDOWSKI , JUAN GABRIEL SOLSONA ROCABERT , MICHAEL RYAN , NATHAN WILDE , ROBERT LEWIS , STEFANIE ROEPER
IPC: C07B59/00 , C07C33/18 , C07C69/96 , C07D215/56
Abstract: a presente invenção refere-se a processos para sintetizar compostos para uso como moduladores de cftr.
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公开(公告)号：AU2010213628A1
公开(公告)日：2011-09-01
申请号：AU2010213628
申请日：2010-02-12
Applicant: VERTEX PHARMA
Inventor： MICHAEL HURREY , DIMITAR ALARGOV , JOHNSTON STEVEN C , STEFANIE ROEPER , SNOONIAN JOHN R , COWANS BRETT A , PETINKA VLAHOVA , ALEXANDER EBERLIN , MARK EDDLESTON , CHRISTOPHER FRAMPTON
IPC: C07D213/82 , A61K31/4418
Abstract: This invention relates to solid forms of 2-(2, 4-difluorophenyl)-6-(l- (2,6-difluorophenyl)ureido)nicotinamide and pharmaceutical compositions thereof, and methods and uses therewith.
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公开(公告)号：AU2010213629A2
公开(公告)日：2011-09-22
申请号：AU2010213629
申请日：2010-02-12
Applicant: VERTEX PHARMA
Inventor： STEFANIE ROEPER , LOOKER ADAM R , MARTINOT THEODORE A , BOBBIANNA NEUBERT-LANGILLE , RYAN MICHAEL P , SNOONIAN JOHN R
IPC: C07D213/80 , A61K31/4418 , A61P29/00 , A61P37/06 , C07D213/803
Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
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公开(公告)号：AU2010213629A1
公开(公告)日：2011-09-01
申请号：AU2010213629
申请日：2010-02-12
Applicant: VERTEX PHARMA
Inventor： STEFANIE ROEPER , LOOKER ADAM R , MARTINOT THEODORE A , BOBBIANNA NEUBERT-LANGILLE , RYAN MICHAEL P , SNOONIAN JOHN R
IPC: C07D213/80 , A61K31/4418 , A61P29/00 , A61P37/06 , C07D213/803
Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
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