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    PYRIMIDINES AND PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES
    2.
    发明申请
    PYRIMIDINES AND PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES 审中-公开
    用作蛋白激酶抑制剂的吡咯烷酮和吡啶

    公开(公告)号：WO2009145814A2

    公开(公告)日：2009-12-03

    申请号：PCT/US2009001534

    申请日：2009-03-10

    Applicant: VERTEX PHARMA ,  HENKEL GREG ,  LIU MICHAEL ,  NEUBERGER TIMOTHY

    Inventor： HENKEL GREG ,  LIU MICHAEL ,  NEUBERGER TIMOTHY

    IPC: A61K31/506 ,  C07D403/02

    CPC classification number: A61K31/4155 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519

    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, such as inhibitors of GSK-3. The invention provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. The invention provides processes for preparing compounds of the invention. The invention provides methods of identifying compounds useful for treatment of diabetes, diabetic neuropathy, osteoporosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, leukocytopenia, cardiomyocyte hypertrophy, stroke, post-stroke, spinal cord injury, traumatic brain injury, Charcot-Marie-Tooth, peripheral nerve regeneration, and rheumatoid arthritis.

    Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物，例如GSK-3的抑制剂。 本发明提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。 本发明提供了制备本发明化合物的方法。 本发明提供鉴定可用于治疗糖尿病，糖尿病性神经病，骨质疏松症，阿尔茨海默病，亨廷顿病，帕金森病，艾滋病相关性痴呆，双相情感障碍，肌萎缩性侧索硬化，多发性硬化，精神分裂症，白细胞减少，心肌细胞肥大，中风的化合物的方法 ，中风后，脊髓损伤，创伤性脑损伤，Charcot-Marie-Tooth，周围神经再生和类风湿性关节炎。

    PYRIMIDINES AND PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES
    3.
    发明申请
    PYRIMIDINES AND PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES 审中-公开
    可用作蛋白激酶抑制剂的嘧啶和吡啶

    公开(公告)号：WO2009145814A3

    公开(公告)日：2010-03-25

    申请号：PCT/US2009001534

    申请日：2009-03-10

    Applicant: VERTEX PHARMA ,  HENKEL GREG ,  LIU MICHAEL ,  NEUBERGER TIMOTHY

    Inventor： HENKEL GREG ,  LIU MICHAEL ,  NEUBERGER TIMOTHY

    IPC: A61K31/4155 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61P3/10 ,  A61P19/10 ,  A61P25/28 ,  A61P35/00

    CPC classification number: A61K31/4155 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519

    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, such as inhibitors of GSK-3. The invention provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. The invention provides processes for preparing compounds of the invention. The invention provides methods of identifying compounds useful for treatment of diabetes, diabetic neuropathy, osteoporosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, leukocytopenia, cardiomyocyte hypertrophy, stroke, post-stroke, spinal cord injury, traumatic brain injury, Charcot-Marie-Tooth, peripheral nerve regeneration, and rheumatoid arthritis.

    Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物，例如GSK-3抑制剂。 本发明提供了包含本发明化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病的方法。 本发明提供了制备本发明化合物的方法。 本发明提供了鉴定用于治疗糖尿病，糖尿病性神经病，骨质疏松症，阿尔茨海默氏病，亨廷顿舞蹈病，帕金森病，AIDS相关性痴呆，双相型障碍，肌萎缩侧索硬化症，多发性硬化症，精神分裂症，白细胞减少症，心肌细胞肥大，中风 ，中风后，脊髓损伤，创伤性脑损伤，Charcot-Marie-Tooth，末梢神经再生和类风湿性关节炎。

    Aminopirimidinas útiles como inhibidores de las proteínas cinasas
    5.
    发明专利
    Aminopirimidinas útiles como inhibidores de las proteínas cinasas 未知

    公开(公告)号：ES2435997T3

    公开(公告)日：2013-12-26

    申请号：ES08731830

    申请日：2008-03-10

    Applicant: VERTEX PHARMA

    Inventor： JIMENEZ JUAN-MIGUEL ,  MILLER ANDREW ,  GREEN JEREMY ,  GAO HUAI ,  HENKEL GREGORY ,  LIU MICHAEL ,  NEUBERGER TIMOTHY

    IPC: C07D403/12 ,  A61K31/506 ,  A61P3/10 ,  A61P25/00 ,  C07D471/04

    Abstract: Un compuesto de fórmula I:**Fórmula** o una de sus sales farmacéuticamente aceptables, donde: Ht es**Fórmula** donde cualquier carbono sustituible de Ht está independiente y opcionalmente sustituido con -R10; el anillo D es un cicloalifático o heterociclilo de 3 a 10 miembros; donde dicho heterociclilo contiene 1 a 2heteroátomos elegidos entre O, N o S; y donde el cicloalifático o heterociclilo está independiente y opcionalmentesustituido con 1 a 5 -R5; el anillo D está enlazado a la pirimidina a través de un átomo de carbono; Z1 es N, CH o CR10; RX es H, halo o C1-6alquilo, donde el alquilo está independiente y opcionalmente sustituido con 1 a 5 grupos elegidosentre halo, -CN y -OR; RY es H, halo, C1-6alquilo o un anillo heterociclilo de 5 a 6 miembros que contiene 1 a 2 heteroátomos elegidos entreO, N o S; donde dicho RY está independiente y opcionalmente sustituido con 1 a 4 halo, CN, OR o C1-6alquilo; cada R10 se elige independientemente entre C1-6alquilo, haloC1-6alquilo, halo, OR, C(>=O)R, CO2R, COCOR, NO2, CN,S(O)R, SO2R, SR, N(R4)2, CON(R4)2, SO2N(R4)2, OC(>=O)R, N(R4) COR o N(R4)CO2R; cada R4 se elige independientemente entre H, C1-6alquilo o haloC1-6alquilo; cada R5 se elige independientemente entre halo, haloC1-6alquilo o C1-6alquilo; y cada R se elige independientemente entre H, C1-6 alquilo o haloC1-6 alquilo; siempre que el compuesto no sea**Fórmula**

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