公开(公告)号：WO2008112651A2

公开(公告)日：2008-09-18

申请号：PCT/US2008056433

申请日：2008-03-10

Applicant: VERTEX PHARMA ,  PIERCE ALBERT ,  COME JON ,  COURT JOHN ,  GAO HUAI ,  HENKEL GREGORY ,  LIU MICHAEL ,  NEUBERGER TIMOTHY

Inventor： PIERCE ALBERT ,  COME JON ,  COURT JOHN ,  GAO HUAI ,  HENKEL GREGORY ,  LIU MICHAEL ,  NEUBERGER TIMOTHY

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：WO2007064797A3

公开(公告)日：2007-12-13

申请号：PCT/US2006045847

申请日：2006-11-30

Applicant: VERTEX PHARMA ,  LAUFFER DAVID ,  ARONOV ALEXANDER ,  LI PAN ,  DEININGER DAVID ,  MCGINTY KIRA ,  STAMOS DEAN ,  COME JON ,  STEWART MICHELLE

Inventor： LAUFFER DAVID ,  ARONOV ALEXANDER ,  LI PAN ,  DEININGER DAVID ,  MCGINTY KIRA ,  STAMOS DEAN ,  COME JON ,  STEWART MICHELLE

IPC: C07D487/04 ,  A61K31/433 ,  A61P35/00 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D498/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.

Abstract translation: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。

公开(公告)号：WO2009020470A3

公开(公告)日：2010-10-21

申请号：PCT/US2007087411

申请日：2007-12-13

Applicant: VERTEX PHARMA ,  GUTIERREZ COREY DON ,  TERMIN ANDREAS ,  HADIDA-RUAH SARA ,  BERGERON DANIELE ,  YOO SANGHEE ,  BINCH HAYLEY ,  JOSHI PRAMOD ,  COME JON ,  NANTHAKUMAR SUGANTHI ,  CAO JINGRONG ,  KRUEGER ELAINE ,  MAXWELL JOHN ,  LE TIRAN ARNAUD ,  LIAO YUSHENG

Inventor： GUTIERREZ COREY DON ,  TERMIN ANDREAS ,  HADIDA-RUAH SARA ,  BERGERON DANIELE ,  YOO SANGHEE ,  BINCH HAYLEY ,  JOSHI PRAMOD ,  COME JON ,  NANTHAKUMAR SUGANTHI ,  CAO JINGRONG ,  KRUEGER ELAINE ,  MAXWELL JOHN ,  LE TIRAN ARNAUD ,  LIAO YUSHENG

IPC: C07D277/14 ,  A61K31/4468 ,  A61K31/517 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D498/10 ,  C07D513/10

CPC classification number: C07D277/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D498/10 ,  C07D513/10

Abstract: The present invention relates to CGRP receptor antagonists of formula I, wherein: X is S, Si, or SO2; pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.

Abstract translation: 本发明涉及式I的CGRP受体拮抗剂，其中：X是S，Si或SO 2; 其药物组合物及其用于治疗CGRP受体介导的疾病和病症的方法。

公开(公告)号：WO2007146349A2

公开(公告)日：2007-12-21

申请号：PCT/US2007013896

申请日：2007-06-13

Applicant: VERTEX PHARMA ,  GUTIERREZ COREY ,  TERMIN ANDREAS ,  HADIDA-RUAH SARA ,  JOSHI PRAMOD ,  BERGERON DANIELE ,  YOO SANGHEE ,  BINCH HAYLEY ,  COME JON ,  NANTHAKUMAR SUGANTHI ,  CAO JINGRONG

Inventor： GUTIERREZ COREY ,  TERMIN ANDREAS ,  HADIDA-RUAH SARA ,  JOSHI PRAMOD ,  BERGERON DANIELE ,  YOO SANGHEE ,  BINCH HAYLEY ,  COME JON ,  NANTHAKUMAR SUGANTHI ,  CAO JINGRONG

CPC classification number: C07D417/14 ,  C07D277/14 ,  C07D417/06 ,  C07D471/04 ,  C07D471/10 ,  C07D498/10 ,  C07D513/10

Abstract: The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.

Abstract translation: 本发明涉及CGRP受体拮抗剂，其药物组合物及其用于治疗CGRP受体介导的疾病和病症的方法。

公开(公告)号：WO2007133622A2

公开(公告)日：2007-11-22

申请号：PCT/US2007011285

申请日：2007-05-10

Applicant: VERTEX PHARMA ,  GREEN JEREMY ,  CAO JINGRONG ,  BANDARAGE UPUL ,  COME JON ,  MARHEFKA CRAIG

Inventor： GREEN JEREMY ,  CAO JINGRONG ,  BANDARAGE UPUL ,  COME JON ,  MARHEFKA CRAIG

IPC: C07D409/04 ,  A61K31/427 ,  A61P35/00 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D409/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14

Abstract: Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurological, or proliferative diseases or disorders.

Abstract translation: 本文描述的是可用作ROCK抑制剂的化合物。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种障碍（包括心血管，炎症，神经或增殖性疾病或病症）的严重性。

公开(公告)号：AU2012203384A8

公开(公告)日：2012-08-02

申请号：AU2012203384

申请日：2012-06-08

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2012203384A1

公开(公告)日：2012-06-28

申请号：AU2012203384

申请日：2012-06-08

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  WANG JIAN ,  PINDER JOANNE ,  WANG TIANSHEN ,  PIERCE ALBERT

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AT540948T

公开(公告)日：2012-01-15

申请号：AT06770824

申请日：2006-05-22

Applicant: VERTEX PHARMA

Inventor： WANNAMAKER MARION ,  LEDEBOER MARK ,  PIERCE ALBERT ,  WANG TIANSHENG ,  FARMER LUC ,  MARTINEZ-BOTELLA GABRIEL ,  BEMIS GUY ,  BETHIEL RANDY ,  COME JON ,  ARNOST MICHAEL ,  SALITURO FRANCESCO ,  WANG JIAN ,  MARHEFKA CRAIG ,  STEWART MICHELLE ,  GREEN JEREMY

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00 ,  C07D487/04

Abstract: The present invention relates to compounds of formula (I) wherein Q, Z, R 1 , R 2 , and R 3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：NZ574097A

公开(公告)日：2012-01-12

申请号：NZ57409707

申请日：2007-06-13

Applicant: VERTEX PHARMA

Inventor： GUTIERREZ COREY ,  TERMIN ANDREAS ,  HADIDA-RUAH SARA ,  JOSHI PRAMOD ,  BERGERON DANIELE ,  YOO SANGHEE ,  BINCH HAYLEY ,  COME JON ,  NANTHAKUMAR SUGANTHI ,  CAO JINGRONG

IPC: C07D277/14 ,  A61K31/4468 ,  A61K31/517 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D498/10 ,  C07D513/10

Abstract: Disclosed is a thiazolidine compound of formula (I) where the substituents are as disclosed in the specification. Example of compound of formula (I) include: 1-(1-(2-(4-Oxo-2-phenyl-3-((pyridin-4-yl)methyl)thiazolidin-5-yl)acetyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 3,4-Dihydro-3-(1-(2-(3-methyl-4-oxo-2-phenylthiazolidin-5-yl)acetyl)piperidin-4-yl)quinazolin-2(1H)-one and 3-(1-(2-(3-Isopentyl-4-oxo-2-phenylthiazolidin-5-yl)propanoyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one. Also disclosed is the pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula9I) in the manufacture of a medicament for treating or preventing headache; migraine; cluster headache; chronic tension type headache; pain; chronic pain; neurogenic inflammation and inflammatory pain; neuropathic pain; eye pain; tooth pain; diabetes; non-insulin dependent diabetes mellitus; vascular disorders; inflammation; arthritis; bronchial hyperactivity, asthma; shock; sepsis; opiate withdrawal syndrome; morphine tolerance; hot flashes in men and women; allergic dermatitis; encephalitis; brain trauma; epilepsy; neurodegenerative diseases; skin diseases; neurogenic cutaneous redness, skin rosaceous and erythema; tinnitus; inflammatory bowel disease, irritable bowel syndrome, or cystitis.

公开(公告)号：PL1730146T3

公开(公告)日：2011-10-31

申请号：PL05756052

申请日：2005-03-30

Applicant: VERTEX PHARMA

Inventor： SALITURO FRANCESCO ,  FARMER LUC ,  BETHIEL RANDY ,  HARRINGTON EDMUND ,  GREEN JEREMY ,  COURT JOHN ,  COME JON ,  LAUFFER DAVID ,  ARONOV ALEX ,  BINCH HAYLEY ,  BOYALL DEAN ,  CHARRIER JEAN-DAMIEN ,  EVERITT SIMON ,  FRAYSSE DAMIEN ,  MORTIMORE MICHAEL ,  PIERARD FRANCOISE ,  ROBINSON DANIEL ,  PINDER JOANNE ,  WANG TIANSHENG ,  PIERCE ALBERT ,  WANG JIAN

IPC: C07D471/04 ,  C07D519/00