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公开(公告)号：WO2006023852A3
公开(公告)日：2006-08-31
申请号：PCT/US2005029780
申请日：2005-08-19
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
IPC: A61K31/435 , A61K31/438 , A61P25/00 , A61P43/00 , C07D471/00
CPC classification number: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2006058303A3
公开(公告)日：2006-12-21
申请号：PCT/US2005042967
申请日：2005-11-29
Applicant: VERTEX PHARMA , DRUTU IOANA , HURLEY DENNIS J , BANDARAGE UPUL K , BERGERON DANIELE M , CHARIFSON PAUL S , DAVIES ROBERT J , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL
Inventor： DRUTU IOANA , HURLEY DENNIS J , BANDARAGE UPUL K , BERGERON DANIELE M , CHARIFSON PAUL S , DAVIES ROBERT J , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL
IPC: A61K31/4747 , A61K31/435 , A61K31/439 , A61K31/444 , A61K31/4545 , A61P1/00 , A61P3/04 , A61P9/00 , A61P17/02 , A61P25/00 , A61P27/02 , A61P43/00 , C07D471/00
CPC classification number: C07D471/10 , A61K31/435 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4747 , C07D471/08 , C07D491/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
Abstract translation: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供了包含这种调节剂的组合物，以及用于治疗毒蕈碱性受体介导的疾病的方法。
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公开(公告)号：WO2005026137A3
公开(公告)日：2005-07-21
申请号：PCT/US2004029206
申请日：2004-09-07
Applicant: VERTEX PHARMA , MILLER MARK T , HADIDA RUAH SARA S , SINGH ASHAVINI K , CLEVELAND THOMAS , MAKINGS LEWIS R , HAMILTON MATTHEW , GROOTENHUIS PETER D J
Inventor： MILLER MARK T , HADIDA RUAH SARA S , SINGH ASHAVINI K , CLEVELAND THOMAS , MAKINGS LEWIS R , HAMILTON MATTHEW , GROOTENHUIS PETER D J
IPC: A61K31/426 , A61K31/427 , A61P43/00 , C07D263/48 , C07D277/46 , C07D277/82 , C07D417/02 , C07D417/04 , C07D417/06 , C07D417/12
CPC classification number: A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including CF Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：WO2008021375A3
公开(公告)日：2008-07-24
申请号：PCT/US2007018012
申请日：2007-08-15
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , HURLEY DENNIS J , RAFFAI GABRIEL
Inventor： MAKINGS LEWIS R , HURLEY DENNIS J , RAFFAI GABRIEL
IPC: A61K31/527 , A61K31/537 , A61P1/00 , A61P9/00 , A61P11/06 , A61P17/02 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P43/00
CPC classification number: A61K31/527 , A61K31/537 , C07D471/10 , C07D498/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2004108133A3
公开(公告)日：2005-03-31
申请号：PCT/US2004017779
申请日：2004-06-04
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GROOTENHUIS PETER , HURLEY DENNIS JAMES , TUNG ROGER D , TERMIN ANDREAS P
Inventor： MAKINGS LEWIS R , GROOTENHUIS PETER , HURLEY DENNIS JAMES , TUNG ROGER D , TERMIN ANDREAS P
IPC: A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/497 , A61K31/501 , A61K31/506 , A61P1/00 , A61P11/00 , A61P11/06 , A61P13/10 , A61P17/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P43/00 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/44 , C07D263/58 , C07D277/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/02 , C07D498/02
CPC classification number: A61K31/497 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/501 , A61K31/506 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/44 , C07D263/58 , C07D277/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: The present invention relates to compounds useful as modulators of the vanilloid receptor, and also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作香草素受体调节剂的化合物，并且还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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Patent Agency Ranking
公开(公告)号：WO2007076070A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049141
申请日：2006-12-22
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
CPC classification number: A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2006105035A3
公开(公告)日：2006-11-16
申请号：PCT/US2006011139
申请日：2006-03-28
Applicant: VERTEX PHARMA , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , RAFFAI GABRIEL , ZUNIC VALENTIN BORIS
Inventor： DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , RAFFAI GABRIEL , ZUNIC VALENTIN BORIS
IPC: A61K31/46 , A61K31/4468 , A61K31/453 , A61P25/00 , C07D211/58 , C07D401/04 , C07D451/04
CPC classification number: C07D211/58 , A61K31/4468 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/502 , A61K31/52 , A61K31/53 , C07D451/04 , C07D519/00
Abstract: The present invention relates to modulators of muscarinic receptors formula (I). The present invention also provides compositions comprising such modulators/ and methods therewith for treating muscarinic receptor mediated diseases.
Abstract translation: 本发明涉及式（I）的毒蕈碱受体调节剂。 本发明还提供包含这样的调节剂的组合物和/或其用于治疗毒蕈碱受体介导的疾病的方法。
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公开(公告)号：WO2006058294A2
公开(公告)日：2006-06-01
申请号：PCT/US2005042931
申请日：2005-11-29
Applicant: VERTEX PHARMA , HURLEY DENNIS J , BERGERON DANIELE M , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL , SILINA ALINA
Inventor： HURLEY DENNIS J , BERGERON DANIELE M , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL , SILINA ALINA
CPC classification number: C07D211/10 , A61K31/4439 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/52 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D417/10 , C07D417/12 , C07D451/02 , C07D493/08
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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9.发明申请
公开(公告)号：WO2005030188A3
公开(公告)日：2005-08-04
申请号：PCT/US2004031514
申请日：2004-09-27
Applicant: VERTEX PHARMA , GARCIA-GUZMAN BLANCO MIGUEL , BERGERON DANIELE , GROOTENHUIS PETER D J , HURLEY DENNIS JAMES , NAKATANI AKIKO , MAKINGS LEWIS R , DISEPIO DANIEL , RAFFAI GABRIEL
Inventor： GARCIA-GUZMAN BLANCO MIGUEL , BERGERON DANIELE , GROOTENHUIS PETER D J , HURLEY DENNIS JAMES , NAKATANI AKIKO , MAKINGS LEWIS R , DISEPIO DANIEL , RAFFAI GABRIEL
IPC: A61K31/495 , A61K31/496 , C07D295/02 , C07D295/033 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D309/14 , C07D451/02 , C07D451/04 , C07D493/08 , A61P43/00 , C07D295/04
CPC classification number: C07D295/033 , A61K31/495 , A61K31/496 , C07D211/58 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D309/14 , C07D451/02 , C07D451/04 , C07D493/08
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
Abstract translation: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供了包含这种调节剂的组合物，以及用于治疗毒蕈碱性受体介导的疾病的方法。
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公开(公告)号：ZA200609893B
公开(公告)日：2008-08-27
申请号：ZA200609893
申请日：2006-11-27
Applicant: VERTEX PHARMA
Inventor： MAKINGS LEWIS R , MIGUEL GARCIA-GUZMAN BLANCO , AKIKO NAKATANI , HURLEY DENNIS J , BERGERON DANIELE M
IPC: A61K20090101 , A61K31/454 , A61K31/496 , A61K31/506 , A61P20090101 , C07D213/74 , C07D213/82 , C07D213/85 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/24 , C07D401/04 , C07D451/04
Abstract: The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.
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