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公开(公告)号：WO2006023852A3
公开(公告)日：2006-08-31
申请号：PCT/US2005029780
申请日：2005-08-19
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
IPC: A61K31/435 , A61K31/438 , A61P25/00 , A61P43/00 , C07D471/00
CPC classification number: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2006058303A3
公开(公告)日：2006-12-21
申请号：PCT/US2005042967
申请日：2005-11-29
Applicant: VERTEX PHARMA , DRUTU IOANA , HURLEY DENNIS J , BANDARAGE UPUL K , BERGERON DANIELE M , CHARIFSON PAUL S , DAVIES ROBERT J , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL
Inventor： DRUTU IOANA , HURLEY DENNIS J , BANDARAGE UPUL K , BERGERON DANIELE M , CHARIFSON PAUL S , DAVIES ROBERT J , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL
IPC: A61K31/4747 , A61K31/435 , A61K31/439 , A61K31/444 , A61K31/4545 , A61P1/00 , A61P3/04 , A61P9/00 , A61P17/02 , A61P25/00 , A61P27/02 , A61P43/00 , C07D471/00
CPC classification number: C07D471/10 , A61K31/435 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4747 , C07D471/08 , C07D491/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
Abstract translation: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供了包含这种调节剂的组合物，以及用于治疗毒蕈碱性受体介导的疾病的方法。
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公开(公告)号：WO2007076070A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049141
申请日：2006-12-22
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
CPC classification number: A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2006058294A2
公开(公告)日：2006-06-01
申请号：PCT/US2005042931
申请日：2005-11-29
Applicant: VERTEX PHARMA , HURLEY DENNIS J , BERGERON DANIELE M , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL , SILINA ALINA
Inventor： HURLEY DENNIS J , BERGERON DANIELE M , DRUTU IOANA , GARCIA-GUZMAN BLANCO MIGUEL , MAKINGS LEWIS R , NAKATANI AKIKO , RAFFAI GABRIEL , SILINA ALINA
CPC classification number: C07D211/10 , A61K31/4439 , C07D211/18 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/52 , C07D211/64 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D417/10 , C07D417/12 , C07D451/02 , C07D493/08
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：NZ553202A
公开(公告)日：2010-12-24
申请号：NZ55320205
申请日：2005-08-19
Applicant: VERTEX PHARMA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
IPC: A61K31/435 , A61K31/438 , A61P25/00 , A61P43/00 , C07D471/00
Abstract: Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt therof wherein the substituent G is a adamantyl, or a bicyclic or a tricyclic group of formula (III) and the remaining substituents are as defined in the specification. Also disclosed is the use of the compounds for treating muscarinic receptor mediated diseases such as CNS derived pathologies, Attention Deficit Hyperactivity Disorder (ADHD), obesity, Alzheimer's disease and dementia.
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Patent Agency Ranking
公开(公告)号：AU2007221220A1
公开(公告)日：2007-09-07
申请号：AU2007221220
申请日：2007-02-22
Applicant: VERTEX PHARMA
Inventor： SILINA ALINA , NAKATANI AKIKO , BLANCO MIGUEL GARCIA-GUZMAN , DRUTU IOANA , MAKINGS LEWIS R , TERMIN ANDREAS P , BERGERON DANIELE M , RAFFAI GABRIEL , HURLEY DENNIS J
IPC: C07D471/10 , A61K31/438 , A61K31/46 , A61K31/4747 , A61P25/00 , C07D519/00
Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：NO20073369L
公开(公告)日：2007-08-29
申请号：NO20073369
申请日：2007-06-29
Applicant: VERTEX PHARMA
Inventor： CHARIFSON PAUL S , DAVIES ROBERT J , MAKINGS LEWIS R , BLANCO MIGUEL GARCIA-GUZMAN , HURLEY DENNIS JAMES , NAKATANI AKIKO , RAFFAI GABRIEL , DRUTU IOANA , BANDARAGE UPUL K , BERGERON DANIELE M
IPC: A61K31/4353 , A61P25/00 , C07D471/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：NO20084007A
公开(公告)日：2008-10-07
申请号：NO20084007
申请日：2008-09-19
Applicant: VERTEX PHARMA
Inventor： MAKINGS LEWIS R , BLANCO MIGUEL GARCIA-GUZMAN , NAKATANI AKIKO , DRUTU IOANA , BERGERON DANIELE M , TERMIN ANDREAS P , RAFFAI GABRIEL , SILINA ALINA , HURLEY DENNIS J
IPC: C07D471/10 , C07D519/00
CPC classification number: C07D471/10
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公开(公告)号：CA2642649A1
公开(公告)日：2007-09-07
申请号：CA2642649
申请日：2007-02-22
Applicant: VERTEX PHARMA
Inventor： TERMIN ANDREAS P , BERGERON DANIELE M , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , SILINA ALINA , NAKATANI AKIKO
IPC: C07D471/10 , A61K31/438 , A61K31/46 , A61K31/4747 , A61P25/00 , C07D519/00
Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：AU2005249494A1
公开(公告)日：2005-12-15
申请号：AU2005249494
申请日：2005-05-31
Applicant: VERTEX PHARMA
Inventor： BLANCO MIGUEL GARCIA-GUZMAN , NAKATANI AKIKO , BERGERON DANIELE M , HURLEY DENNIS J , MAKINGS LEWIS R
IPC: A61K31/454 , A61K31/496 , A61K31/506 , C07D213/74 , C07D213/82 , C07D213/85 , C07D237/24 , C07D239/42 , C07D241/20 , C07D241/24 , C07D401/04 , C07D451/04
Abstract: The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.
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