公开(公告)号：WO2006058303A3

公开(公告)日：2006-12-21

申请号：PCT/US2005042967

申请日：2005-11-29

Applicant: VERTEX PHARMA ,  DRUTU IOANA ,  HURLEY DENNIS J ,  BANDARAGE UPUL K ,  BERGERON DANIELE M ,  CHARIFSON PAUL S ,  DAVIES ROBERT J ,  GARCIA-GUZMAN BLANCO MIGUEL ,  MAKINGS LEWIS R ,  NAKATANI AKIKO ,  RAFFAI GABRIEL

Inventor： DRUTU IOANA ,  HURLEY DENNIS J ,  BANDARAGE UPUL K ,  BERGERON DANIELE M ,  CHARIFSON PAUL S ,  DAVIES ROBERT J ,  GARCIA-GUZMAN BLANCO MIGUEL ,  MAKINGS LEWIS R ,  NAKATANI AKIKO ,  RAFFAI GABRIEL

IPC: A61K31/4747 ,  A61K31/435 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61P1/00 ,  A61P3/04 ,  A61P9/00 ,  A61P17/02 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00 ,  C07D471/00

CPC classification number: C07D471/10 ,  A61K31/435 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4747 ,  C07D471/08 ,  C07D491/08 ,  C07D491/10

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Abstract translation: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供了包含这种调节剂的组合物，以及用于治疗毒蕈碱性受体介导的疾病的方法。

公开(公告)号：WO2007016292A3

公开(公告)日：2007-04-12

申请号：PCT/US2006029291

申请日：2006-07-26

Applicant: VERTEX PHARMA ,  BARTELS DOUGLAS JOHN ,  HURLEY DENNIS J

Inventor： BARTELS DOUGLAS JOHN ,  HURLEY DENNIS J

IPC: C07D417/12 ,  A61K31/404 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4709 ,  A61P31/04 ,  C07D405/12 ,  C07D409/14

CPC classification number: C07D417/12 ,  C07D405/12 ,  C07D409/14

Abstract: Compounds described herein are useful in modulating bacterial biofilms.

Abstract translation: 本文所述的化合物可用于调节细菌生物膜。

公开(公告)号：WO2006023852A3

公开(公告)日：2006-08-31

申请号：PCT/US2005029780

申请日：2005-08-19

Applicant: VERTEX PHARMA ,  MAKINGS LEWIS R ,  GARCIA-GUZMAN BLANCO MIGUEL ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  BERGERON DANIELE M ,  NAKATANI AKIKO ,  TERMIN ANDREAS P ,  SILINA ALINA

Inventor： MAKINGS LEWIS R ,  GARCIA-GUZMAN BLANCO MIGUEL ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  BERGERON DANIELE M ,  NAKATANI AKIKO ,  TERMIN ANDREAS P ,  SILINA ALINA

IPC: A61K31/435 ,  A61K31/438 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00

CPC classification number: C07D401/06 ,  A61K31/435 ,  A61K31/438 ,  A61K31/4747 ,  A61K31/55 ,  C07D221/20 ,  C07D223/32 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D451/02 ,  C07D451/04 ,  C07D471/10 ,  C07D491/10

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：WO2007076070A2

公开(公告)日：2007-07-05

申请号：PCT/US2006049141

申请日：2006-12-22

Applicant: VERTEX PHARMA ,  MAKINGS LEWIS R ,  GARCIA-GUZMAN BLANCO MIGUEL ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  BERGERON DANIELE M ,  NAKATANI AKIKO ,  TERMIN ANDREAS P ,  SILINA ALINA

Inventor： MAKINGS LEWIS R ,  GARCIA-GUZMAN BLANCO MIGUEL ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  BERGERON DANIELE M ,  NAKATANI AKIKO ,  TERMIN ANDREAS P ,  SILINA ALINA

CPC classification number: A61K31/4545 ,  A61K31/438 ,  A61K31/46 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  C07D221/20 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D417/14 ,  C07D471/10 ,  C07D487/08 ,  C07D491/10

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：WO2006058294A2

公开(公告)日：2006-06-01

申请号：PCT/US2005042931

申请日：2005-11-29

Applicant: VERTEX PHARMA ,  HURLEY DENNIS J ,  BERGERON DANIELE M ,  DRUTU IOANA ,  GARCIA-GUZMAN BLANCO MIGUEL ,  MAKINGS LEWIS R ,  NAKATANI AKIKO ,  RAFFAI GABRIEL ,  SILINA ALINA

Inventor： HURLEY DENNIS J ,  BERGERON DANIELE M ,  DRUTU IOANA ,  GARCIA-GUZMAN BLANCO MIGUEL ,  MAKINGS LEWIS R ,  NAKATANI AKIKO ,  RAFFAI GABRIEL ,  SILINA ALINA

CPC classification number: C07D211/10 ,  A61K31/4439 ,  C07D211/18 ,  C07D211/32 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/52 ,  C07D211/64 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/10 ,  C07D417/10 ,  C07D417/12 ,  C07D451/02 ,  C07D493/08

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：WO2008021375A3

公开(公告)日：2008-07-24

申请号：PCT/US2007018012

申请日：2007-08-15

Applicant: VERTEX PHARMA ,  MAKINGS LEWIS R ,  HURLEY DENNIS J ,  RAFFAI GABRIEL

Inventor： MAKINGS LEWIS R ,  HURLEY DENNIS J ,  RAFFAI GABRIEL

IPC: A61K31/527 ,  A61K31/537 ,  A61P1/00 ,  A61P9/00 ,  A61P11/06 ,  A61P17/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P27/02 ,  A61P27/06 ,  A61P43/00

CPC classification number: A61K31/527 ,  A61K31/537 ,  C07D471/10 ,  C07D498/10

Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

公开(公告)号：WO2006028904A9

公开(公告)日：2006-06-22

申请号：PCT/US2005031146

申请日：2005-08-31

Applicant: VERTEX PHARMA ,  WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  FANNING LEV T D ,  NEUBERT TIMOTHY D ,  KRENITSKY PAUL ,  JOSHI PRAMOD ,  HURLEY DENNIS J ,  SHETH URVI ,  BOGER JOSHUA S

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  FANNING LEV T D ,  NEUBERT TIMOTHY D ,  KRENITSKY PAUL ,  JOSHI PRAMOD ,  HURLEY DENNIS J ,  SHETH URVI ,  BOGER JOSHUA S

IPC: C07D239/94 ,  A61K31/498 ,  A61P9/06 ,  A61P25/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14

CPC classification number: C07D401/04 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及用作电压门控钠通道抑制剂的化合物。 本发明还提供了包含本发明化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病的方法。

公开(公告)号：ZA201102900B

公开(公告)日：2012-07-25

申请号：ZA201102900

申请日：2011-04-18

Applicant: VERTEX PHARMA

Inventor： BINCH HAYLEY ,  FANNING LEV T D ,  HURLEY DENNIS J ,  SHETH URVI ,  SILINA ALINA ,  YANG XIAOQING ,  BOTFIELD MARTYN C ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK ,  NUMA MEHDI MICHEL DJAMEL

IPC: A61K20060101 ,  C07D20060101 ,  A61P20060101 ,  C12Q20060101

Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.

公开(公告)号：NZ553202A

公开(公告)日：2010-12-24

申请号：NZ55320205

申请日：2005-08-19

Applicant: VERTEX PHARMA

Inventor： MAKINGS LEWIS R ,  GARCIA-GUZMAN BLANCO MIGUEL ,  HURLEY DENNIS J ,  DRUTU IOANA ,  RAFFAI GABRIEL ,  BERGERON DANIELE M ,  NAKATANI AKIKO ,  TERMIN ANDREAS P ,  SILINA ALINA

IPC: A61K31/435 ,  A61K31/438 ,  A61P25/00 ,  A61P43/00 ,  C07D471/00

Abstract: Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt therof wherein the substituent G is a adamantyl, or a bicyclic or a tricyclic group of formula (III) and the remaining substituents are as defined in the specification. Also disclosed is the use of the compounds for treating muscarinic receptor mediated diseases such as CNS derived pathologies, Attention Deficit Hyperactivity Disorder (ADHD), obesity, Alzheimer's disease and dementia.

公开(公告)号：ZA200702375B

公开(公告)日：2009-03-25

申请号：ZA200702375

申请日：2005-08-31

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  FANNING LEV T D ,  NEUBERT TIMOTHY D ,  PAUL KRENITSKY ,  PRAMOD JOSHI ,  HURLEY DENNIS J ,  URVI SHETH ,  BOGER JOSHUA S

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.