公开(公告)号：AU2004263179B8

公开(公告)日：2011-07-14

申请号：AU2004263179

申请日：2004-08-09

Applicant: VERTEX PHARMA

Inventor： GONZALES III JESUS E ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMAN ,  TERMIN ANDREAS P

IPC: C07C311/46 ,  A61K31/513 ,  A61K31/517 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/5415 ,  C07C311/51 ,  C07D209/80 ,  C07D209/92 ,  C07D213/76 ,  C07D231/38 ,  C07D231/42 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/54 ,  C07D239/545 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16 ,  C07D263/50 ,  C07D277/52 ,  C07D277/82 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.

公开(公告)号：AU2004263179B2

公开(公告)日：2011-06-30

申请号：AU2004263179

申请日：2004-08-09

Applicant: VERTEX PHARMA

Inventor： GONZALES JESUS E III ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMAN ,  TERMIN ANDREAS P

IPC: C07C311/46 ,  A61K31/513 ,  A61K31/517 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/5415 ,  C07C311/51 ,  C07D209/80 ,  C07D209/92 ,  C07D213/76 ,  C07D231/38 ,  C07D231/42 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/54 ,  C07D239/545 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16 ,  C07D263/50 ,  C07D277/52 ,  C07D277/82 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.

公开(公告)号：AU2004263179A8

公开(公告)日：2011-07-14

申请号：AU2004263179

申请日：2004-08-09

Applicant: VERTEX PHARMA

Inventor： GONZALES III JESUS E ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMAN ,  TERMIN ANDREAS P

IPC: C07C311/46 ,  A61K31/513 ,  A61K31/517 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/5415 ,  C07C311/51 ,  C07D209/80 ,  C07D209/92 ,  C07D213/76 ,  C07D231/38 ,  C07D231/42 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/54 ,  C07D239/545 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16 ,  C07D263/50 ,  C07D277/52 ,  C07D277/82 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.

公开(公告)号：ZA200802977B

公开(公告)日：2009-08-26

申请号：ZA200802977

申请日：2006-09-08

Applicant: VERTEX PHARMA

Inventor： TIMOTHY NIEUBERT ,  NICOLE ZIMMERMAN ,  ARTIS KAWATKAR ,  ESTHER MARTINBOROUGH ,  ANDREAS TERMIN

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.