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公开(公告)号：AU2004263179A8
公开(公告)日：2011-07-14
申请号：AU2004263179
申请日：2004-08-09
Applicant: VERTEX PHARMA
Inventor： GONZALES III JESUS E , ESTHER MARTINBOROUGH , NICOLE ZIMMERMAN , TERMIN ANDREAS P
IPC: C07C311/46 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
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公开(公告)号：NO20061080L
公开(公告)日：2006-04-19
申请号：NO20061080
申请日：2006-03-06
Applicant: VERTEX PHARMA
Inventor： GONZALES III JESUS E , WILSON DEAN MIRCHELL , ZHANG YULIAN , NEUBERT TIMOTHY DONALD , MARTINBOROUGH ESTHER , ZIMMERMANN NICOLE , TERMIN ANDREAS PETER , WANG JIAN
IPC: C07D239/94 , A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：NO20061092L
公开(公告)日：2006-04-27
申请号：NO20061092
申请日：2006-03-07
Applicant: VERTEX PHARMA
IPC: C07D285/12 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：NO20061080A
公开(公告)日：2006-04-19
申请号：NO20061080
申请日：2006-03-06
Applicant: VERTEX PHARMA
Inventor： GONZALES III JESUS E , WILSON DEAN MIRCHELL , ZHANG YULIAN , NEUBERT TIMOTHY DONALD , MARTINBOROUGH ESTHER , ZIMMERMANN NICOLE , TERMIN ANDREAS PETER , WANG JIAN
IPC: C07D239/94 , A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04
CPC classification number: C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
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公开(公告)号：NO20054546A
公开(公告)日：2005-11-25
申请号：NO20054546
申请日：2005-10-03
Applicant: VERTEX PHARMA
Inventor： GONZALES III JESUS E , WILSON DEAN MIRCHELL , TERMIN ANDREAS PETER , GROOTENHUIS PETER DIEDERIK JAN , ZHANG YULIAN , PETZOLDT BENJAMIN JOHN , FANNING LEV TYLER DEWEY , NEUBERT TIMOTHY DONALD , TUNG ROGER D , MARTINBOROUGH ESTHER , ZIMMERMANN NICOLE
IPC: C07D239/94 , A61K31/517 , A61K31/5377 , A61K31/541 , C07D20060101 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04
CPC classification number: C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
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Patent Agency Ranking
公开(公告)号：PE10592004A1
公开(公告)日：2005-02-07
申请号：PE0002362004
申请日：2004-03-03
Applicant: VERTEX PHARMA
Inventor： WILSON DEAN MITCHELL , TERMIN ANDREAS PETER , GROOTENHUIS PETER DIEDERIK JAN , PETZOLDT BENJAMIN JOHN , NEUBERT TIMOTHY DONALD , GONZALES III JESUS E , ZIMMERMANN NICOLE , MARTINBOROUGH ESTHER , TUNG ROGER D , FANNING LEV TYLER DEWEY , ZHANG YULIAN
IPC: A61K31/517 , A61K31/5377 , A61K31/541 , C07D20060101 , C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04
CPC classification number: C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: SE REFIERE A QUINAZOLINAS DE FORMULA I DONDE R1 Y R2 JUNTO A ATOMO DE N AL CUAL ESTAN ENLAZADOS FORMAN UN MONOCICLICO O BICICLICO SATURADO CON 3 A 12 MIEMBROS; EL ANILLO A ES UN ARILO MONOCICLICO CON 5 A 7 MIEMBROS O UN ANILLO BICICLICO DE 8 A 10 MIEMBROS QUE CONTIENE 0 A 3 HETEROATOMOS SELECCIONADOS DE N, O, S; x ES 0 A 4; R3, R4 Y R5 SON Q-RX DONDE Q ES UN ENLACE O UNA CADENA ALQUILIDENO CARACTERIZADO PORQUE HASTA DOS UNIDADES DE METILENO NO ADYACENTE DE Q SON REEMPLAZADAS POR -NR-, -S-, -O-, -CS, -CO2-, ENTRE OTROS; CADA R ES H, GRUPO ALIFATICO C1-C6, DONDE CADA OCURRENCIA DE R' ES H, GRUPO ALIFATICO C1-C6, ANILLO MONOCICLO SATURADO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 2-(2-METOXI-FENIL)-7-TRIFLUOROMETIL-3H-QUINAZOLIN-4-ONA ENTRE OTROS. LOS COMPUESTOS DE FORMULA I ACTUAN COMOMODULADORES DE CANALES IONICOS SODICOS Y CALCICOS Y SON UTILES PARA EL TRATAMIENTO DE DOLOR, ARTRITIS, MIGRANA, TRASTORNOS NEURODEGENARATIVOS
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公开(公告)号：AU2004263179B8
公开(公告)日：2011-07-14
申请号：AU2004263179
申请日：2004-08-09
Applicant: VERTEX PHARMA
Inventor： GONZALES III JESUS E , ESTHER MARTINBOROUGH , NICOLE ZIMMERMAN , TERMIN ANDREAS P
IPC: C07C311/46 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
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公开(公告)号：ZA200507979B
公开(公告)日：2007-03-28
申请号：ZA200507979
申请日：2004-03-03
Applicant: VERTEX PHARMA INC
Inventor： GONZALES III JESUS E , MITCHELL WILSON DEAN , PETER TERMIN ANDREAS , GROOTENHUIS PETER DIEDERIK JAN , YULIAN ZHANG , JOHN PETZOLDT BENJAMAIN , DEWEY FANNING LEV TYLER , DONALD NEUBERT TIMOTHY , TUNG ROGER D , ESTHER MARTINBOUROUGH , NICOLE ZIMMERMANN
IPC: A61K20090101 , C07D20090101
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公开(公告)号：NO20061092A
公开(公告)日：2006-04-27
申请号：NO20061092
申请日：2006-03-07
Applicant: VERTEX PHARMA
IPC: C07D285/12 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
CPC classification number: C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
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公开(公告)号：NO20054546D0
公开(公告)日：2005-10-03
申请号：NO20054546
申请日：2005-10-03
Applicant: VERTEX PHARMA
Inventor： GONZALES III JESUS E , WILSON DEAN MIRCHELL , TERMIN ANDREAS PETER , GROOTENHUIS PETER DIEDERIK JAN , ZHANG YULIAN , PETZOLDT BENJAMIN JOHN , FANNING LEV TYLER DEWEY , NEUBERT TIMOTHY DONALD , TUNG ROGER D , MARTINBOROUGH ESTHER , ZIMMERMANN NICOLE
IPC: A61K31/517 , A61K31/5377 , A61K31/541 , C07D20060101 , C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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