公开(公告)号：ZA200601942B

公开(公告)日：2007-05-30

申请号：ZA200601942

申请日：2004-08-09

Applicant: VERTEX PHARMA

Inventor： GONZALES JESUS E III ,  TERMIN ANDREAS P ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMANN

IPC: C07C20090101 ,  C07D20090101

公开(公告)号：AT548358T

公开(公告)日：2012-03-15

申请号：AT04780401

申请日：2004-08-05

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  TERMIN ANDREAS ,  NEUBERT TIMOTHY ,  JIAN WANG ,  YULIAN ZHANG ,  JESUS E GONZALEZ III ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMANN

IPC: C07D239/94 ,  A61K31/517 ,  A61K31/5377 ,  A61P25/00 ,  A61P29/00 ,  C07D239/70 ,  C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/02 ,  C07D471/04 ,  C07D495/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2004263179B8

公开(公告)日：2011-07-14

申请号：AU2004263179

申请日：2004-08-09

Applicant: VERTEX PHARMA

Inventor： GONZALES III JESUS E ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMAN ,  TERMIN ANDREAS P

IPC: C07C311/46 ,  A61K31/513 ,  A61K31/517 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/5415 ,  C07C311/51 ,  C07D209/80 ,  C07D209/92 ,  C07D213/76 ,  C07D231/38 ,  C07D231/42 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/54 ,  C07D239/545 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16 ,  C07D263/50 ,  C07D277/52 ,  C07D277/82 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.

公开(公告)号：UY28463A1

公开(公告)日：2005-02-28

申请号：UY28463

申请日：2004-08-09

Applicant: VERTEX PHARMA

Inventor： NICOLE ZIMMERMANN ,  III GONZALEZ JESUS E ,  TERMIN ANDREAS P ,  ESTHER MARTINBOROUGH

IPC: A61P3/00

Abstract: La presente invención se refiere a compuestos útiles como inhibidores de los canales de sodio regulados por voltaje. La invención también proporciona composiciones farmacéuticamente aceptables que comprende los compuestos de la invención y métodos para usar las composiciones en el tratamiento de varios trastornos.

公开(公告)号：AU2004263179B2

公开(公告)日：2011-06-30

申请号：AU2004263179

申请日：2004-08-09

Applicant: VERTEX PHARMA

Inventor： GONZALES JESUS E III ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMAN ,  TERMIN ANDREAS P

IPC: C07C311/46 ,  A61K31/513 ,  A61K31/517 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/5415 ,  C07C311/51 ,  C07D209/80 ,  C07D209/92 ,  C07D213/76 ,  C07D231/38 ,  C07D231/42 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/54 ,  C07D239/545 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16 ,  C07D263/50 ,  C07D277/52 ,  C07D277/82 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.

公开(公告)号：ZA200710332B

公开(公告)日：2009-03-25

申请号：ZA200710332

申请日：2006-05-12

Applicant: VERTEX PHARMA

Inventor： TERMIN ANDREAS P ,  NICOLE ZIMMERMANN ,  LEANNE KNOLL TARA ,  GABRIEL MARTINEZ-BOTELLA ,  ESTHER MARTINBOROUGH

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101

Abstract: The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2011250764A1

公开(公告)日：2011-12-08

申请号：AU2011250764

申请日：2011-11-14

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  NEUBERT TIMOTHY D ,  ESTHER MARTINBOROUGH ,  JIAN WANG ,  YULIAN ZHANG ,  NICOLE ZIMMERMANN ,  GONZALEZ III JESUS E

IPC: C07D471/04 ,  A61P25/00 ,  A61P29/00 ,  C07D239/70 ,  C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D495/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2005265270B2

公开(公告)日：2011-09-22

申请号：AU2005265270

申请日：2005-06-22

Applicant: VERTEX PHARMA

Inventor： COHEN CHARLES J ,  ESTHER MARTINBOROUGH ,  DON GUTIERREZ COREY ,  NICOLE ZIMMERMANN ,  TERMIN ANDREAS P

IPC: C07D209/04 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61P19/00 ,  A61P25/08 ,  A61P25/14 ,  A61P29/00 ,  C07D261/20

Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.

公开(公告)号：AU2004263179A8

公开(公告)日：2011-07-14

申请号：AU2004263179

申请日：2004-08-09

Applicant: VERTEX PHARMA

Inventor： GONZALES III JESUS E ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMAN ,  TERMIN ANDREAS P

IPC: C07C311/46 ,  A61K31/513 ,  A61K31/517 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/5415 ,  C07C311/51 ,  C07D209/80 ,  C07D209/92 ,  C07D213/76 ,  C07D231/38 ,  C07D231/42 ,  C07D237/20 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/54 ,  C07D239/545 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16 ,  C07D263/50 ,  C07D277/52 ,  C07D277/82 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.

公开(公告)号：AU2004217891B2

公开(公告)日：2011-06-23

申请号：AU2004217891

申请日：2004-03-03

Applicant: VERTEX PHARMA

Inventor： DEWEY FANNING LEV TYLER ,  TUNG ROGER D ,  YULIAN ZHANG ,  GONZALES JESUS E III ,  PETER TERMIN ANDREAS ,  DONALD NEUBERT TIMOTHY ,  ESTHER MARTINBOROUGH ,  JOHN PETZOLDT BENJAMIN ,  JAN GROOTENHUIS PETER DIEDERIK ,  MITCHELL WILSON DEAN ,  NICOLE ZIMMERMANN

IPC: C07D239/94 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D20060101 ,  C07D239/91 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R, X, R, x, and ring A are as defined in the present application.