公开(公告)号：WO2014160568A3

公开(公告)日：2014-12-31

申请号：PCT/US2014031186

申请日：2014-03-19

Applicant: WATERS TECHNOLOGIES CORP

Inventor： ANDREWS RICHARD W

IPC: G01N21/59

CPC classification number: G01N30/74 ,  G01N21/274 ,  G01N21/3103 ,  G01N21/59 ,  G01N30/8631 ,  G01N30/8665 ,  G01N2201/127

Abstract: The invention generally provides methods for improving the dynamic range of an absorbance detector and absorbance detectors having improved dynamic range. In an exemplary embodiment, the method includes receiving calibration data for a plurality of samples, the calibration data comprising an absorbance for a concentration of each of the samples, calculating a contribution of stray light to the calibration data, and correcting subsequent data by removing the contribution of stray light.

Abstract translation: 本发明总体上提供了用于改善具有改进的动态范围的吸光度检测器和吸光度检测器的动态范围的方法。 在示例性实施例中，该方法包括接收多个样本的校准数据，该校准数据包括每个样本的浓度的吸光度，计算杂散光对校准数据的贡献，以及通过去除 杂散光的贡献。

公开(公告)号：DE102014116571A1

公开(公告)日：2015-05-13

申请号：DE102014116571

申请日：2014-11-13

Applicant: WATERS TECHNOLOGIES CORP

Inventor： KEENAN PAUL ,  JOUDREY KURT D ,  ANDREWS RICHARD W ,  BEALS PAYTON C ,  SHREVE JOSHUA A

IPC: G01N30/00 ,  B01D15/40

Abstract: Verfahren zur Steuerung eines Fluids, das durch ein chromatographisches System strömt, wobei das Verfahren das Bestimmen eines fluidischen Parameters in Bezug auf die Dichte an einer ersten fluidischen Stelle im Chromatographiesystem umfasst; und, in Reaktion auf den bestimmten fluidischen Parameter, Modifizieren einer volumetrischen Flussrate oder eines Drucks an einer zweiten fluidischen Stelle im chromatographischen System, um eine ausgewählte Massenflussrate des Fluids zu erzeugen.

公开(公告)号：HK1164407A1

公开(公告)日：2012-09-21

申请号：HK12104955

申请日：2012-05-21

Applicant: WATERS TECHNOLOGIES CORP

Inventor： CORMIER SYLVAIN ,  ANDREWS RICHARD W ,  TACCONI ROBERT ,  DOBBS CRAIG H

IPC: F04B20060101

公开(公告)号：HK1244053A1

公开(公告)日：2018-07-27

申请号：HK18102750

申请日：2018-02-26

Applicant: WATERS TECHNOLOGIES CORP

Inventor： CORMIER SYLVAIN ,  ANDREWS RICHARD W ,  BEALS PEYTON C

IPC: G01N20060101 ,  G06F20060101

公开(公告)号：EP2401502A4

公开(公告)日：2016-10-19

申请号：EP10746644

申请日：2010-02-17

Applicant: WATERS TECHNOLOGIES CORP

Inventor： CORMIER SYLVAIN ,  ANDREWS RICHARD W ,  TACCONI ROBERT ,  DOBBS CRAIG H

IPC: F04B13/02 ,  F04B23/06 ,  G01N1/38 ,  G01N1/40 ,  G01N30/20

CPC classification number: F04B13/02 ,  F04B23/06 ,  G01N1/38 ,  G01N1/40 ,  G01N30/20

Abstract: Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.