公开(公告)号：WO2019145920A1

公开(公告)日：2019-08-01

申请号：PCT/IB2019/050675

申请日：2019-01-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LAUBER, Matthew A. ,  NGUYEN, Jennifer M. ,  ZHANG, Ximo ,  RANBADUGE, Nilini ,  BIRDSALL, Robert ,  SHION, Henry

IPC: B01D15/16 ,  B01D15/30 ,  G01N30/34 ,  B01D15/32

CPC classification number: B01D15/426 ,  B01D15/166 ,  B01D15/305 ,  B01D15/325 ,  B01D15/327 ,  B01J20/283 ,  B01J20/287 ,  G01N30/34 ,  G01N30/7233 ,  G01N30/7266 ,  G01N30/84 ,  G01N2030/8452

Abstract: The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.