公开(公告)号：WO2019145920A1

公开(公告)日：2019-08-01

申请号：PCT/IB2019/050675

申请日：2019-01-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LAUBER, Matthew A. ,  NGUYEN, Jennifer M. ,  ZHANG, Ximo ,  RANBADUGE, Nilini ,  BIRDSALL, Robert ,  SHION, Henry

IPC: B01D15/16 ,  B01D15/30 ,  G01N30/34 ,  B01D15/32

CPC classification number: B01D15/426 ,  B01D15/166 ,  B01D15/305 ,  B01D15/325 ,  B01D15/327 ,  B01J20/283 ,  B01J20/287 ,  G01N30/34 ,  G01N30/7233 ,  G01N30/7266 ,  G01N30/84 ,  G01N2030/8452

Abstract: The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

公开(公告)号：WO2021144765A1

公开(公告)日：2021-07-22

申请号：PCT/IB2021/050318

申请日：2021-01-16

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： BIRDSALL, Robert ,  KELLETT, Jacob ,  RANBADUGE, Nilini ,  YU, Ying Qing ,  NGUYEN, Jennifer M. ,  LAUBER, Matthew A.

IPC: G01N30/56 ,  G01N2030/567 ,  G01N2030/8831

Abstract: The present disclosure discusses a method of separating a sample (e.g., peptide compound) including coating a flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample – and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating (e.g., organosilica coating) of the flow path. The applied coating can reduce peak tailing and increase analyte recovery for the sample of the chromatographic system.

公开(公告)号：EP4090965A1

公开(公告)日：2022-11-23

申请号：EP21701019.8

申请日：2021-01-16

Applicant: Waters Technologies Corporation

Inventor： BIRDSALL, Robert ,  KELLETT, Jacob ,  RANBADUGE, Nilini ,  YU, Ying Qing ,  NGUYEN, Jennifer M. ,  LAUBER, Matthew A.

IPC: G01N30/56