公开(公告)号：WO2021195212A1

公开(公告)日：2021-09-30

申请号：PCT/US2021/023887

申请日：2021-03-24

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： NGUYEN, Jennifer M. ,  LAUBER, Matthew A. ,  ALELYUNAS, Yun Wang ,  ROMAN, Gregory T. ,  SHION, Henry Y.

IPC: G01N30/34 ,  B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  B01J20/281 ,  G01N30/60 ,  G01N30/88 ,  G01N30/30 ,  G01N30/72 ,  G01N30/74 ,  G01N30/52 ,  G01N30/62 ,  B01D15/166 ,  B01D15/327 ,  B01D53/10 ,  B01J20/28078 ,  B01J20/285 ,  B01J20/287 ,  C07K1/18 ,  C07K1/20 ,  G01N2030/525 ,  G01N2030/626 ,  G01N2030/8831 ,  G01N30/6052

Abstract: The present disclosure provides devices, systems, kits and methods useful for quantitation of biomolecules such as intact proteins and nucleic acids.

公开(公告)号：WO2021144765A1

公开(公告)日：2021-07-22

申请号：PCT/IB2021/050318

申请日：2021-01-16

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： BIRDSALL, Robert ,  KELLETT, Jacob ,  RANBADUGE, Nilini ,  YU, Ying Qing ,  NGUYEN, Jennifer M. ,  LAUBER, Matthew A.

IPC: G01N30/56 ,  G01N2030/567 ,  G01N2030/8831

Abstract: The present disclosure discusses a method of separating a sample (e.g., peptide compound) including coating a flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample – and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating (e.g., organosilica coating) of the flow path. The applied coating can reduce peak tailing and increase analyte recovery for the sample of the chromatographic system.

公开(公告)号：WO2023073635A1

公开(公告)日：2023-05-04

申请号：PCT/IB2022/060393

申请日：2022-10-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LAUBER, Matthew A. ,  NGUYEN, Jennifer M. ,  LIU, Xiaoxiao ,  DONEGAN, Michael

IPC: C12Q1/6806

Abstract: The present disclosure provides compositions and methods for sample processing, particularly for oligonucleotide analysis e.g. analysis of formulated nucleic acid drugs. A composition for pretreating at least one target nucleic acid in a biological mixture provided herein includes a chaotropic agent selected from a substituted guanidine, a substituted amidine, a substituted quaternary amine, or a combination thereof, an optional protease, and/or an optional disulfide-reducing agent. Methods of analyzing at least one target nucleic acid in a biological mixture is also provided herein. Furthermore, the present disclosure provides methods for quantifying at least one target cationic lipid interacting with a nucleic acid.

公开(公告)号：WO2022064447A1

公开(公告)日：2022-03-31

申请号：PCT/IB2021/058741

申请日：2021-09-24

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： DELANO, Mathew ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  NGUYEN, Jennifer M.

IPC: G01N30/60

Abstract: The present disclosure relates to a method of reducing degradation of sample components in a liquid chromatography system. The method utilizes a masked metal frit to prevent or reduce metal surfaces from becoming catalytically active. The masked metal frit is a metal based frit that includes a coating on its exterior surfaces to mask or prevent contact between the organic solvents (and/or any analyte or other related solvent) and the underlying metal. The coating is a vapor deposited inorganic-organic hybrid coating, such as a vapor deposited C2 coating.

公开(公告)号：WO2019145920A1

公开(公告)日：2019-08-01

申请号：PCT/IB2019/050675

申请日：2019-01-28

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LAUBER, Matthew A. ,  NGUYEN, Jennifer M. ,  ZHANG, Ximo ,  RANBADUGE, Nilini ,  BIRDSALL, Robert ,  SHION, Henry

IPC: B01D15/16 ,  B01D15/30 ,  G01N30/34 ,  B01D15/32

CPC classification number: B01D15/426 ,  B01D15/166 ,  B01D15/305 ,  B01D15/325 ,  B01D15/327 ,  B01J20/283 ,  B01J20/287 ,  G01N30/34 ,  G01N30/7233 ,  G01N30/7266 ,  G01N30/84 ,  G01N2030/8452

Abstract: The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

公开(公告)号：EP4090965A1

公开(公告)日：2022-11-23

申请号：EP21701019.8

申请日：2021-01-16

Applicant: Waters Technologies Corporation

Inventor： BIRDSALL, Robert ,  KELLETT, Jacob ,  RANBADUGE, Nilini ,  YU, Ying Qing ,  NGUYEN, Jennifer M. ,  LAUBER, Matthew A.

IPC: G01N30/56

公开(公告)号：EP4522302A1

公开(公告)日：2025-03-19

申请号：EP23727687.8

申请日：2023-05-08

Applicant: Waters Technologies Corporation

Inventor： LAUBER, Matthew A. ,  DONEANU, Catalin ,  CHEN, Weibin ,  YU, Ying Qing ,  NGUYEN, Jennifer M. ,  GRITTI, Fabrice ,  GILAR, Martin

IPC: B01D15/32 ,  B01D15/34 ,  G01N30/54 ,  G01N30/72 ,  G01N30/74 ,  C12N15/10 ,  B01D15/38 ,  B01D15/42

公开(公告)号：EP4127704A1

公开(公告)日：2023-02-08

申请号：EP21719770.6

申请日：2021-03-24

Applicant: Waters Technologies Corporation

Inventor： NGUYEN, Jennifer M. ,  LAUBER, Matthew A. ,  ALELYUNAS, Yun Wang ,  ROMAN, Gregory T. ,  SHION, Henry Y.

IPC: G01N30/34 ,  B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  B01J20/281 ,  G01N30/60 ,  G01N30/88 ,  G01N30/30 ,  G01N30/72 ,  G01N30/74 ,  G01N30/52 ,  G01N30/62

公开(公告)号：EP4423294A1

公开(公告)日：2024-09-04

申请号：EP22818107.9

申请日：2022-10-28

Applicant: Waters Technologies Corporation

Inventor： LAUBER, Matthew A. ,  NGUYEN, Jennifer M. ,  LIU, Xiaoxiao ,  DONEGAN, Michael

IPC: C12Q1/6806

CPC classification number: C12Q1/6806

公开(公告)号：EP4217730A1

公开(公告)日：2023-08-02

申请号：EP21793998.2

申请日：2021-09-24

Applicant: Waters Technologies Corporation

Inventor： DELANO, Mathew ,  LAUBER, Matthew A. ,  WYNDHAM, Kevin ,  NGUYEN, Jennifer M.

IPC: G01N30/60